CAJ | 학술논문

目的观察他汀类药物对高胆固醇血症绝经后妇女骨密度(BMD)及骨代谢标志物的影响及其对骨质疏松症(OP)的治疗机制.方法将2011年1月至2012年8月就诊的100例符合入组标准的骨量减少或骨质疏松合并高胆固醇血症的绝经后妇女随机分为两组,即对照组和治疗组(服用阿托伐他汀钙10 mg qd).观察两组患者半年、1年后腰椎BMD、骨吸收标志物Ⅰ型胶原交联C-端肽(CTX)、骨合成标志物Ⅰ型前胶原N-端肽(PINP)的变化情况,并进行组内及组间比较.结果治疗组的腰椎BMD及PINP在半年及1年后均有上升的趋势.治疗组腰椎BMD与对照组相比差异有统计学意义,(0.68 ±0.14)比(0.74 ±0.12),(P＜0.05).治疗组PINP值在1年后明显改善,(38.8±8.9)比(40.2±8.6),(P＜0.05),该差值高于对照组的差值,两者差异也有统计学意义,(38.4±8.6)比(42.1±8.3),(P＜0.05).结论他汀类药物对维持或增加高胆固醇血症绝经后妇女骨量有一定帮助,它是通过促进骨合成代谢来实现其抗骨质疏松的作用.
목적 관찰타정류약물대고담고순혈증절경후부녀골밀도(BMD)급골대사표지물적영향급기대골질소송증(OP)적치료궤제.방법 장2011년1월지2012년8월취진적100례부합입조표준적골량감소혹골질소송합병고담고순혈증적절경후부녀수궤분위량조,즉대조조화치료조(복용아탁벌타정개10 mg qd).관찰량조환자반년、1년후요추BMD、골흡수표지물Ⅰ형효원교련C-단태(CTX)、골합성표지물Ⅰ형전효원N-단태(PINP)적변화정황,병진행조내급조간비교.결과 치료조적요추BMD급PINP재반년급1년후균유상승적추세.치료조요추BMD여대조조상비차이유통계학의의,(0.68 ±0.14)비(0.74 ±0.12),(P＜0.05).치료조PINP치재1년후명현개선,(38.8±8.9)비(40.2±8.6),(P＜0.05),해차치고우대조조적차치,량자차이야유통계학의의,(38.4±8.6)비(42.1±8.3),(P＜0.05).결론 타정류약물대유지혹증가고담고순혈증절경후부녀골량유일정방조,타시통과촉진골합성대사래실현기항골질소송적작용.
Objective To explore the effects of statins upon bone mineral density (BMD) and bone metabolic markers in postmenopausal women with hypercholesterolemia.Methods A prospective study was conducted for 100 women receiving treatment from January 2011 to August 2012 and meeting the inclusion criteria of osteopenia or osteoporosis with hypercholesterolemia postmenopausal.They were randomly divided into treatment group on atorvastatin 10 mg once daily and control group.The parameters of lumbar BMD,bone resorption markers of type Ⅰ collagen cross-linked C-telopeptide (CTX),bone synthesis markers procollagen type Ⅰ N-terminal peptide (PINP) were compared between two groups after half a year and one year.Results There was an upward trend of lumbar spine BMD and PINP in the treatment group at half a year and one year compared with the control group.And two groups had significant difference (P ＜ 0.05).Although two groups had no significant difference in all parameters at half a year,the values of lumbar spine BMD and PINP were higher in the treatment group at one year than the control group.Two groups had significant difference (P ＜ 0.05).Conclusions Statins can help maintain or increase bone mass of hypercholesterolemic menopausal women through promoting bone synthesis.