CAJ | 학술논문

目的探讨蛋白酪氨酸磷酸酶IB(PTP1B)在非小细胞肺癌(NSCLC)组织中的表达及其对预后的预测价值.方法运用免疫组织化学EnVision法,检测2000年6月至2006年10月南京军区南京总医院手术切除的经常规病理证实的63例NSCLC肺癌组织和9例肺炎组织中PTP1B的表达并进行统计学分析,探讨其与临床病理特征和预后的关系.结果 PTP1B在肺炎组织中均为阴性表达,在NSCLC组织中的表达阳性率为50.8％(32/63),显著高于肺炎组(x2=8.229,P=0.004)；PTP1B在NSCLC组织中的表达与性别、年龄、吸烟、肿瘤大小、病理类型、淋巴结转移及化疗与否无明显相关,而与pTNM分期显著相关(X2=6.426,P=0.040).Kaplan-Meire生存分析显示,PTP1B表达与肺癌患者的总生存期明显相关(Log-rank,P=0.047).多因素Cox回归分析显示PTP1B的表达是影响NSCLC预后的独立因素(HR=2.050,P=0.044),pTNM分期也是影响NSCLC独立预后因素(HR =3.631,P=0.000).结论 PTP1B在肺癌发生发展中起重要的作用,PTP1B及pTNM分期是NSCLC独立的预后因素.
목적 탐토단백락안산린산매IB(PTP1B)재비소세포폐암(NSCLC)조직중적표체급기대예후적예측개치.방법 운용면역조직화학EnVision법,검측2000년6월지2006년10월남경군구남경총의원수술절제적경상규병리증실적63례NSCLC폐암조직화9례폐염조직중PTP1B적표체병진행통계학분석,탐토기여림상병리특정화예후적관계.결과 PTP1B재폐염조직중균위음성표체,재NSCLC조직중적표체양성솔위50.8％(32/63),현저고우폐염조(x2=8.229,P=0.004)；PTP1B재NSCLC조직중적표체여성별、년령、흡연、종류대소、병리류형、림파결전이급화료여부무명현상관,이여pTNM분기현저상관(X2=6.426,P=0.040).Kaplan-Meire생존분석현시,PTP1B표체여폐암환자적총생존기명현상관(Log-rank,P=0.047).다인소Cox회귀분석현시PTP1B적표체시영향NSCLC예후적독립인소(HR=2.050,P=0.044),pTNM분기야시영향NSCLC독립예후인소(HR =3.631,P=0.000).결론 PTP1B재폐암발생발전중기중요적작용,PTP1B급pTNM분기시NSCLC독립적예후인소.
Objective To explore the protein-tyrosine-phosphatase 1B (PTP1B) expression and its prognostic significance in non-small-cell lung cancer (NSCLC).Methods Immunohistochemical method of EnVision was applied to investigate the expression of PTP1B in lung specimens from 63 cases with NSCLC and 9 cases with pneumonia confirmed by pathological examination after surgical removals at Jinling Hospital from June 2000 to October 2010.The data of PTP1B expression in different lung tissues and its relationship with clinicopathological features and prognostic value for survival were analyzed by chi-square test,Kaplan-Meire survival analysis,Log rank test and multivariable Cox regression analysis.Results The expression of PTP1B was negative in pneumonia group while positive in NSCLC tissues (32/63,50.8％) (x2 =8.229,P =0.004).The expression of PTP1B in NSCLC tissue was not correlated with gender,age,smoking history,tumor size,pathological type,lymph node metastasis and chemotherapy,but significantly associated with pTNM staging (x2 =6.426,P =0.040).Kaplan-Meire survival analysis showed that the expression of PTP1B was significantly correlated with overall survival (Log-rank,P =0.047).Multivariable Cox regression analysis indicated that both PTP1B (HR =2.050,P =0.044) and pTNM staging (HR =3.631,P =0.000) were independent prognostic factors for NSCLC.Conclusions PTP1B may be a biomarker for differential diagnosis of malignant lung disease.And PTP1B and pTNM were independent prognostic factors for NSCLC.