CAJ | 학술논문

目的研究血清胱抑素C与代谢综合征(MS)的相关性.方法回顾性分析2008年2月-2011年4月山东大学第二医院患者和体检者的病历资料共506例,其中代谢综合征患者191例、代谢异常患者210例,健康体检者105名.按照血清胱抑素C水平又将入选者分为3组:下三分位数组(T1组)165例,中分位数组(T2组)172例,上三分位数组(T3组)169例,检测体重指数(BMI)、腰围、腰臀比、空腹血糖(FPG)、糖化血红蛋白(HbA1 c)、低密度脂蛋白胆固醇(LDL-C)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、肌酐、估计的肾小球滤过率(eGFR)、尿微量白蛋白(MAU)、收缩压、舒张压、脉压差及胱抑素C,并进行统计学分析.结果 (1)T1、T2、T3三组间BMI、腰围、腰臀比、FPG、HbA1c、LDL-C、TG、肌酐、eGFR、MAU、收缩压、舒张压和脉压差的差异均有统计学意义(均P ＜0.05).(2)随着三分位数水平的增加,T1、T2、T3组MS患病率均显著增加(均P＜0.01).(3)T1、T2、T3三组间患者的MS组分积分差异均有统计学意义(均P＜0.01).随着MS组分评分分值的增加,患者的胱抑素C水平逐渐增加,即MS组分值越高,患者血清的胱抑素C水平越高.(4)MS组患者的血清胱抑素C水平与腰围、LDL-C、FBG、HbA1c和血压密切相关(均P＜0.05),与TG水平无明显相关(P=0.059)；与HDL-C水平负相关(r=-0.352,P=0.01).(5)腰围、胱抑素C、LDL-C、MAU和脉压差与MS显著相关,其中胱抑素C与MS的OR=2.943 (95％ CI1.276～3.914).结论胱抑素C与MS显著相关,随着MS积分的升高,胱抑素C呈上升趋势.
목적 연구혈청광억소C여대사종합정(MS)적상관성.방법 회고성분석2008년2월-2011년4월산동대학제이의원환자화체검자적병력자료공506례,기중대사종합정환자191례、대사이상환자210례,건강체검자105명.안조혈청광억소C수평우장입선자분위3조:하삼분위수조(T1조)165례,중분위수조(T2조)172례,상삼분위수조(T3조)169례,검측체중지수(BMI)、요위、요둔비、공복혈당(FPG)、당화혈홍단백(HbA1 c)、저밀도지단백담고순(LDL-C)、감유삼지(TG)、고밀도지단백담고순(HDL-C)、기항、고계적신소구려과솔(eGFR)、뇨미량백단백(MAU)、수축압、서장압、맥압차급광억소C,병진행통계학분석.결과 (1)T1、T2、T3삼조간BMI、요위、요둔비、FPG、HbA1c、LDL-C、TG、기항、eGFR、MAU、수축압、서장압화맥압차적차이균유통계학의의(균P ＜0.05).(2)수착삼분위수수평적증가,T1、T2、T3조MS환병솔균현저증가(균P＜0.01).(3)T1、T2、T3삼조간환자적MS조분적분차이균유통계학의의(균P＜0.01).수착MS조분평분분치적증가,환자적광억소C수평축점증가,즉MS조분치월고,환자혈청적광억소C수평월고.(4)MS조환자적혈청광억소C수평여요위、LDL-C、FBG、HbA1c화혈압밀절상관(균P＜0.05),여TG수평무명현상관(P=0.059)；여HDL-C수평부상관(r=-0.352,P=0.01).(5)요위、광억소C、LDL-C、MAU화맥압차여MS현저상관,기중광억소C여MS적OR=2.943 (95％ CI1.276～3.914).결론 광억소C여MS현저상관,수착MS적분적승고,광억소C정상승추세.
Objective To explore the correlation between serum levels of Cystatin C and metabolic syndrome.Methods This study was randomly conducted in 506 persons,including 191 patients with metabolic syndrome (MS),210 with metabolic disorder (MD) and 105 persons in normal control (NC) group.According to serum levels of Cys C,the clinical data were also divided into 3 groups of lower tertile (T1,n =165),middle tertile (T2,n =172) and upper tertile (T3,n =169).Body mass index (BMI),waist circumference (WC),waist-hip ratio (WHR),fasting plasma glucose (FPG),low-density lipoprotein cholesterol (LDL-C),triglyceride (TG),high density lipoprotein (HDL),creatinine (Cr),estimated glomerular filtration rate (eGFR),microalbuminuria (MAU),systolic blood pressure (SBP),diastolic blood pressure (DBP) and pulse pressure (PP) were measured and their mutual relations evaluated.Results Statistically significant differences (all P ＜ 0.01) existed among T1,T2 and T3 groups in the mean values of BMI,waist circumference,WHR,FPG,LDL-C,TG,Cr,eGFR,MAU,SBP,DBP and PP.As tertile levels of Cys C increased,MS morbidity rates became all remarkably augmented (P ＜ 0.01).The MS component scores had significant statistical differences among the patients of T1,T2 and T3 groups (P ＜ 0.01).As the MS component scores increased,the level of Cys C rose in these patients.The higher MS marks were,the higher serum concentration of Cys C was in these patients.The plasma concentration of Cys C in MS patients was closely related with WC,LDL-C,FBG and blood pressure (all P ＜ 0.05),not related with TG levels and negatively correlated with HDL-C levels (r =-0.352,P =0.01).WC,Cys C,LDL-C,MAU and PP were significantly associated with MS.And the value of OR between Cys C and MS was 2.943 (95％ CI 1.276-3.914).Conclusion Cys C is significantly associated with MS.As MS scores rise,the level of Cys C increases.