中华医学杂志
中華醫學雜誌
중화의학잡지
National Medical Journal of China
2013年
47期
3776-3778
,共3页
强光亮%余其多%肖飞%郭永庆
彊光亮%餘其多%肖飛%郭永慶
강광량%여기다%초비%곽영경
肺肿瘤%基因表达%遗传异质性
肺腫瘤%基因錶達%遺傳異質性
폐종류%기인표체%유전이질성
Lung neoplasms%Gene expression%Genetic heterogeneity
目的 研究UNC-112蛋白在肺癌组织中的表达情况及意义.方法 应用免疫组化SP法检测2010年1月至2013年1月北京中日友好医院胸外科210例肺癌组织中UNC-112蛋白的表达情况,并对UNC-112蛋白表达与病理分型的关系进行统计学分析.结果 UNC-112A和UNC-112B蛋白均在非小细胞肺癌中高表达,在小细胞肺癌中低表达或不表达(P＜0.05);UNC-112A蛋白在鳞癌的表达高于腺癌(P＜0.01)和大细胞癌(P＜0.01),腺癌与大细胞癌之间差异无统计学意义(P=0.18);UNC-112A蛋白表达水平与鳞癌的分化程度呈正相关(P =0.0024).UNC-112B蛋白在大细胞癌的表达高于腺癌(P =0.002)和鳞癌(P＜0.01),在腺癌的表达高于鳞癌(P=0.005).结论 UNC-112蛋白可能与肺癌的异质性有关,UNC-112A和UNC-112B蛋白在肺癌的侵袭、迁移过程中起不同的作用.
目的 研究UNC-112蛋白在肺癌組織中的錶達情況及意義.方法 應用免疫組化SP法檢測2010年1月至2013年1月北京中日友好醫院胸外科210例肺癌組織中UNC-112蛋白的錶達情況,併對UNC-112蛋白錶達與病理分型的關繫進行統計學分析.結果 UNC-112A和UNC-112B蛋白均在非小細胞肺癌中高錶達,在小細胞肺癌中低錶達或不錶達(P＜0.05);UNC-112A蛋白在鱗癌的錶達高于腺癌(P＜0.01)和大細胞癌(P＜0.01),腺癌與大細胞癌之間差異無統計學意義(P=0.18);UNC-112A蛋白錶達水平與鱗癌的分化程度呈正相關(P =0.0024).UNC-112B蛋白在大細胞癌的錶達高于腺癌(P =0.002)和鱗癌(P＜0.01),在腺癌的錶達高于鱗癌(P=0.005).結論 UNC-112蛋白可能與肺癌的異質性有關,UNC-112A和UNC-112B蛋白在肺癌的侵襲、遷移過程中起不同的作用.
목적 연구UNC-112단백재폐암조직중적표체정황급의의.방법 응용면역조화SP법검측2010년1월지2013년1월북경중일우호의원흉외과210례폐암조직중UNC-112단백적표체정황,병대UNC-112단백표체여병리분형적관계진행통계학분석.결과 UNC-112A화UNC-112B단백균재비소세포폐암중고표체,재소세포폐암중저표체혹불표체(P＜0.05);UNC-112A단백재린암적표체고우선암(P＜0.01)화대세포암(P＜0.01),선암여대세포암지간차이무통계학의의(P=0.18);UNC-112A단백표체수평여린암적분화정도정정상관(P =0.0024).UNC-112B단백재대세포암적표체고우선암(P =0.002)화린암(P＜0.01),재선암적표체고우린암(P=0.005).결론 UNC-112단백가능여폐암적이질성유관,UNC-112A화UNC-112B단백재폐암적침습、천이과정중기불동적작용.
Objective To investigate the expression of UNC-112 protein in lung cancer and discuss its value.Methods The method of immunohistochemical SP was employed to detect the expression of UNC112 protein in 210 cases of lung cancer,and evaluate its correlation with pathological classification.Results UNC-112A and UNC-112B protein were highly expressed in non-small cell lung cancer,not expressed or expressed at very low levels in small cell lung cancer(P ＜ 0.05) ; the expression of UNC-112A protein in squamous cell carcinoma was significantly higher than those in adenocarcinoma (P ＜ 0.001) and large cell lung cancer (P ＜ 0.01),but there is no significant difference between adenocarcinoma and large cell lung cancer (P =0.18).UNC-112A protein expression level was positively correlated with the differentiation of squamous cell carcinoma(P =0.0024).The expression of UNC-1 12B protein was significantly higher in large cell lung cancer than those in adenocarcinoma (P =0.002) and squamous cell carcinoma (P ＜ 0.01),and it was significantly higher in adenocarcinoma than squamous cell carcinoma (P =0.005).Conclusions UNC112 protein may be related to the heterogeneity of lung cancer,UNC-112A and UNC-112B protein play different roles in invasion and migration of lung cancer.
