中华医学杂志
中華醫學雜誌
중화의학잡지
National Medical Journal of China
2013年
48期
3861-3863
,共3页
王昕%冯勤付%王文彦%高纪东%宣立学%王靖%李晔雄%王翔
王昕%馮勤付%王文彥%高紀東%宣立學%王靖%李曄雄%王翔
왕흔%풍근부%왕문언%고기동%선립학%왕정%리엽웅%왕상
乳腺肿瘤%乳房成形术%放射疗法
乳腺腫瘤%乳房成形術%放射療法
유선종류%유방성형술%방사요법
Breast neoplasms%Mammaplasty%Radiotherapy
目的 探讨早期乳腺癌保乳术中采用术中电子线局部放疗取代常规术后全乳放疗的安全性和可行性.方法 对中国医学科学院肿瘤医院2008年7月至2012年12月收治的36例早期乳腺癌女性患者采用Mobetron 1000移动式电子束术中放疗系统行保乳手术后联合局部术中放疗.观察初步治疗效果、切口愈合情况、美容效果及不良反应.结果 中位随访时间27.9个月,截止至随访日,2例(5.56％)出现局部复发后行全乳切除术,全部患者均未出现远处转移,无死亡病例.2例(5.56％)出现切口感染,2例(5.56％)出现切口延迟愈合,中位愈合时间17 d.1例(2.78％)有切口水肿.未见切口脂肪液化或血肿.美容效果评价:32例优秀或良好(88.89％),4例一般或差(11.11％).不良反应:未见术中放疗相关急性血液学毒性.2例(5.56％)出现轻度皮肤色素沉着.结论 术中放疗的近期疗效尚可,美容效果好,不良反应小,并发症少见,临床安全性高,而远期疗效等评价仍需进一步研究.
目的 探討早期乳腺癌保乳術中採用術中電子線跼部放療取代常規術後全乳放療的安全性和可行性.方法 對中國醫學科學院腫瘤醫院2008年7月至2012年12月收治的36例早期乳腺癌女性患者採用Mobetron 1000移動式電子束術中放療繫統行保乳手術後聯閤跼部術中放療.觀察初步治療效果、切口愈閤情況、美容效果及不良反應.結果 中位隨訪時間27.9箇月,截止至隨訪日,2例(5.56％)齣現跼部複髮後行全乳切除術,全部患者均未齣現遠處轉移,無死亡病例.2例(5.56％)齣現切口感染,2例(5.56％)齣現切口延遲愈閤,中位愈閤時間17 d.1例(2.78％)有切口水腫.未見切口脂肪液化或血腫.美容效果評價:32例優秀或良好(88.89％),4例一般或差(11.11％).不良反應:未見術中放療相關急性血液學毒性.2例(5.56％)齣現輕度皮膚色素沉著.結論 術中放療的近期療效尚可,美容效果好,不良反應小,併髮癥少見,臨床安全性高,而遠期療效等評價仍需進一步研究.
목적 탐토조기유선암보유술중채용술중전자선국부방료취대상규술후전유방료적안전성화가행성.방법 대중국의학과학원종류의원2008년7월지2012년12월수치적36례조기유선암녀성환자채용Mobetron 1000이동식전자속술중방료계통행보유수술후연합국부술중방료.관찰초보치료효과、절구유합정황、미용효과급불량반응.결과 중위수방시간27.9개월,절지지수방일,2례(5.56％)출현국부복발후행전유절제술,전부환자균미출현원처전이,무사망병례.2례(5.56％)출현절구감염,2례(5.56％)출현절구연지유합,중위유합시간17 d.1례(2.78％)유절구수종.미견절구지방액화혹혈종.미용효과평개:32례우수혹량호(88.89％),4례일반혹차(11.11％).불량반응:미견술중방료상관급성혈액학독성.2례(5.56％)출현경도피부색소침착.결론 술중방료적근기료효상가,미용효과호,불량반응소,병발증소견,림상안전성고,이원기료효등평개잉수진일보연구.
Objective To evaluate the safety and feasibility of intraoperative radiotherapy during breast-conserving surgery instead of whole breast radiotherapy in early breast cancer patients.Methods From July 2008 to December 2012,36 early breast cancer patients underwent breast-conserving surgery plus interoperative radiotherapy on a Mobetron 1000 mobile electron accelerator.Postoperative recurrence and metastases,complications and cosmetic outcomes were recorded and analyzed.Results During a median follow-up period of 27.9 months,2 patients(5.56％)underwent mastectomy after local relapses.There was no occurrence of distant metastasis or mortality.Their average wound healing time was 17 days and 2 of them (5.56％) developed infection while another 2 (5.56％) had delayed wound healing.And 1 patient (2.78％) showed wound edema and neither lyponecrosis nor hematoma was found.The evaluation of cosmetic outcome shows 32 patients(88.89％)were graded as excellent or good while another 4 (11.11％)fair or poor.None had radiotherapy-related acute hemotological toxicity and 2 patients (5.56％) developed skin pigmentation.Conclusion Intraoperative radiotherapy during breast-conserving surgery instead of whole breast radiotherapy in early breast cancer patients is both safe and reliable with better cosmetic outcomes.
