CAJ | 학술논문

目的评估钆塞酸二钠(GD-EOB-DTPA) MR肝胆期对肝硬化背景肝癌的诊断价值.方法收集2011年10月至2012年12月,南通市第三人民医院43例肝硬化患者共45枚肝癌病灶,均行T2WI、DWI、T1WI同反相位、GD-EOB-DTPA动态增强及肝胆期扫描.由2位阅片者分别对有、无肝胆期图像两种成像方法独立阅片.比较阅片者诊断肝癌的信心评分、一致性、ROC曲线下面积、敏感性及阳性预测值.结果增加肝胆期图像:(1)两位阅片者诊断肝癌的信心评分均有增加,差异有统计学意义(P＜0.05),且两位阅片者诊断肝癌的一致性提高;(2)两位阅片者诊断肝癌的ROC曲线下面积均有增加,但差异无统计学意义(P>0.05);(3)两位阅片者诊断肝癌的敏感性均有提高,差异有统计学意义(P<0.05),阳性预测值差异无统计学意义(P>0.05).结论 GD-EOB-DTPA MR肝胆期可提高阅片者对肝硬化背景肝癌的诊断信心及敏感性.
목적 평고구새산이납(GD-EOB-DTPA) MR간담기대간경화배경간암적진단개치.방법 수집2011년10월지2012년12월,남통시제삼인민의원43례간경화환자공45매간암병조,균행T2WI、DWI、T1WI동반상위、GD-EOB-DTPA동태증강급간담기소묘.유2위열편자분별대유、무간담기도상량충성상방법독립열편.비교열편자진단간암적신심평분、일치성、ROC곡선하면적、민감성급양성예측치.결과 증가간담기도상:(1)량위열편자진단간암적신심평분균유증가,차이유통계학의의(P＜0.05),차량위열편자진단간암적일치성제고;(2)량위열편자진단간암적ROC곡선하면적균유증가,단차이무통계학의의(P>0.05);(3)량위열편자진단간암적민감성균유제고,차이유통계학의의(P<0.05),양성예측치차이무통계학의의(P>0.05).결론 GD-EOB-DTPA MR간담기가제고열편자대간경화배경간암적진단신심급민감성.
Objective To assess the diagnostic value of hepatobiliary phase imaging with GD-EOB-DTPA for hepatocellular carcinomas (HCC) in cirrhosis. Methods A total of 43 cirrhotic patients with 45 HCC lesions underwent the examinations of T2WI, DWI, T1WI in-phase and opposed-phase and dynamic contrast enhancement and hepatobiliary phase. Two separate analyses of imaging set with and without hepatobiliary phase images were performed. The confidence scores for HCC diagnosis, consistency, area under the receiver operating characteristic (ROC) curve and sensitivity and positive predictive values of two observers were compared. Results After adding hepatobiliary phase, there was a significant increase of confidence scores in diagnosing HCC by both observers (P<0.05) and the consistency of two observers also increased. The area under the ROC curve improved by both observers, but no significant differences were detected (P>0.05). The sensitivity increased significantly (P<0.05) and no significant differences were observed for the positive predictive values by both observers (P>0.05). Conclusion Hepatobiliary phase imaging may improve the diagnostic confidence and sensitivity of GD-EOB-DTPA for HCC in cirrhosis.