CAJ | 학술논문

目的研究血清胱抑素C水平变化与帕金森病患者相关临床指标及分期之间的关系.方法收集2011年7月至2012年12月在苏州大学附属第二医院神经内科经临床确诊为帕金森病的患者115例,检测这115例帕金森病患者的血清胱抑素C,选取同时间段内在苏州大学附属第二医院体检中心体检的110名健康中老年人作为对照组,采用SPSS 17.0软件对数据进行统计分析.结果帕金森病组血清胱抑素C平均水平为(1.06±0.20) mg/L,健康对照组为(0.96±0.16) mg/L,组间均数比较差异有统计学意义(t=6.663,P＜0.05).斯皮尔曼等级相关分析提示血清胱抑素C水平只与年龄(r =0.381,P＜0.001)、血肌酐(r=0.267,P =0.004)之间呈正相关,与尿素、尿酸、胆固醇、甘油三酯、高密度脂蛋白、低密度脂蛋白没有相关性(P＞0.05).方差分析提示中晚期帕金森病患者的血清胱抑素C水平较高(P＜0.05).结论血清胱抑素C在帕金森病的进程中可能起一定作用.
목적 연구혈청광억소C수평변화여파금삼병환자상관림상지표급분기지간적관계.방법 수집2011년7월지2012년12월재소주대학부속제이의원신경내과경림상학진위파금삼병적환자115례,검측저115례파금삼병환자적혈청광억소C,선취동시간단내재소주대학부속제이의원체검중심체검적110명건강중노년인작위대조조,채용SPSS 17.0연건대수거진행통계분석.결과 파금삼병조혈청광억소C평균수평위(1.06±0.20) mg/L,건강대조조위(0.96±0.16) mg/L,조간균수비교차이유통계학의의(t=6.663,P＜0.05).사피이만등급상관분석제시혈청광억소C수평지여년령(r =0.381,P＜0.001)、혈기항(r=0.267,P =0.004)지간정정상관,여뇨소、뇨산、담고순、감유삼지、고밀도지단백、저밀도지단백몰유상관성(P＞0.05).방차분석제시중만기파금삼병환자적혈청광억소C수평교고(P＜0.05).결론 혈청광억소C재파금삼병적진정중가능기일정작용.
Objective To explore the role of serum cystatin C level in Parkinson's disease (PD) and evaluate the relationship between cystatin C level and clinical characteristics and different stages of PD.Methods A total of 115 PD patients and 110 healthy controls were recruited.The results of such routine laboratory tests as triglyceride,cholesterol,low-density lipoprotein (LDL),high-density lipoprotein (HDL),creatinine,urea,uric acid and cystatin C were assessed from fasting blood samples at our clinical laboratory center.They were further divided into subgroups according to Hoehn & Yahr (H&Y) staging.Statistical analysis was performed with SPSS version 17.0 software.Results Compared to controls (0.96 ± 0.16 mg/L),the mean serum level of cystatin C was significantly higher in PD patients (1.06 ± 0.20 mg/L).Spearman's correlation analyses showed a positive and significant correlation between cystatin C levels and age as well as creatinine levels.Correlation was not found between cystatin C level and triglyceride,cholesterol,LDL,HDL,urea or uric acid.ANOVA analysis showed that cystatin C had a higher level during the middle and late stages of PD than that during the early stage.Conclusion Cystatin C level may play an important role in the progression of PD.