中华医学杂志
中華醫學雜誌
중화의학잡지
National Medical Journal of China
2014年
11期
813-815
,共3页
帕金森病%非运动症状%生活质量
帕金森病%非運動癥狀%生活質量
파금삼병%비운동증상%생활질량
Parkinson's disease%Non-motor symptoms%Quality of life
目的 探讨非运动症状对帕金森病(PD)患者健康生活质量的影响.方法 对2011年9月至2013年6月于苏州市中医医院神经内科门诊和病房接受治疗的128例原发性PD患者采用问卷调查法,应用帕金森病非运动症状评定量表(NMSS)调查PD患者NMS的发生率和水平;应用帕金森病生活质量调查表(PDQ39)评价PD患者健康相关生活质量的水平.结果 本组PD患者NMS的总体发生率为100％,得分为47 ～229分,平均(124 ±48)分.PD患者所有NMS中发生率最高的症状为“便秘”,NMS的发生与年龄(r=0.226,P＜0.05)、H-Y分期(r=0.442,P＜0.05)、病程(r=0.223,P ＜0.05)呈正相关,而与性别无相关性(r=0.085,P＞0.05);本组PD患者PDQ39的总体水平为10 ～76分,平均(44±16)分.得分最高的4个维度分别为:生活自理能力(60±15)分、运动功能(49±21)分、情感状态(49±28)分、病耻感(48±46)分.女性(x2=-1.821,P＜0.05)、老年和无伴侣(x2=-1.512,P＜0.05)的患者在健康相关生活质量比其他患者差.PD患者的病程(r=0.260,P＜0.05)、疾病严重程度(r=0.259,P＜0.05)的得分与健康相关生活质量的总分呈正相关,NMSS总分与健康相关生活质量总分呈正相关(r =0.686,P＜0.01).结论 NMS普遍存在于帕金森病患者当中,是影响帕金森病患者健康相关生活质量最主要的因素.
目的 探討非運動癥狀對帕金森病(PD)患者健康生活質量的影響.方法 對2011年9月至2013年6月于囌州市中醫醫院神經內科門診和病房接受治療的128例原髮性PD患者採用問捲調查法,應用帕金森病非運動癥狀評定量錶(NMSS)調查PD患者NMS的髮生率和水平;應用帕金森病生活質量調查錶(PDQ39)評價PD患者健康相關生活質量的水平.結果 本組PD患者NMS的總體髮生率為100％,得分為47 ～229分,平均(124 ±48)分.PD患者所有NMS中髮生率最高的癥狀為“便祕”,NMS的髮生與年齡(r=0.226,P＜0.05)、H-Y分期(r=0.442,P＜0.05)、病程(r=0.223,P ＜0.05)呈正相關,而與性彆無相關性(r=0.085,P＞0.05);本組PD患者PDQ39的總體水平為10 ～76分,平均(44±16)分.得分最高的4箇維度分彆為:生活自理能力(60±15)分、運動功能(49±21)分、情感狀態(49±28)分、病恥感(48±46)分.女性(x2=-1.821,P＜0.05)、老年和無伴侶(x2=-1.512,P＜0.05)的患者在健康相關生活質量比其他患者差.PD患者的病程(r=0.260,P＜0.05)、疾病嚴重程度(r=0.259,P＜0.05)的得分與健康相關生活質量的總分呈正相關,NMSS總分與健康相關生活質量總分呈正相關(r =0.686,P＜0.01).結論 NMS普遍存在于帕金森病患者噹中,是影響帕金森病患者健康相關生活質量最主要的因素.
목적 탐토비운동증상대파금삼병(PD)환자건강생활질량적영향.방법 대2011년9월지2013년6월우소주시중의의원신경내과문진화병방접수치료적128례원발성PD환자채용문권조사법,응용파금삼병비운동증상평정량표(NMSS)조사PD환자NMS적발생솔화수평;응용파금삼병생활질량조사표(PDQ39)평개PD환자건강상관생활질량적수평.결과 본조PD환자NMS적총체발생솔위100％,득분위47 ～229분,평균(124 ±48)분.PD환자소유NMS중발생솔최고적증상위“편비”,NMS적발생여년령(r=0.226,P＜0.05)、H-Y분기(r=0.442,P＜0.05)、병정(r=0.223,P ＜0.05)정정상관,이여성별무상관성(r=0.085,P＞0.05);본조PD환자PDQ39적총체수평위10 ～76분,평균(44±16)분.득분최고적4개유도분별위:생활자리능력(60±15)분、운동공능(49±21)분、정감상태(49±28)분、병치감(48±46)분.녀성(x2=-1.821,P＜0.05)、노년화무반려(x2=-1.512,P＜0.05)적환자재건강상관생활질량비기타환자차.PD환자적병정(r=0.260,P＜0.05)、질병엄중정도(r=0.259,P＜0.05)적득분여건강상관생활질량적총분정정상관,NMSS총분여건강상관생활질량총분정정상관(r =0.686,P＜0.01).결론 NMS보편존재우파금삼병환자당중,시영향파금삼병환자건강상관생활질량최주요적인소.
Objective To explore the effects of nom-motor symptoms (NMS) on health-related quality of life (HRQOL) in Parkinson's disease (PD) patients.Methods By convenient sampling,128 PD patients were recruited.NMS was assessed by the non-motor symptoms scale for PD (NMSS) and HRQOL by the 39-item PD Questionnaire (PDQ39).Results All PD patients (100％) had NMS with a general score of(124 ±48).Among these NMS,constipation was ranked the highest and the general level of NMS was significantly positively associated with age (r =0.226,P ＜ 0.05),Hoehn-Yahr staging (r =0.442,P ＜ 0.05) and disease course (r =0.223,P ＜ 0.05).However there was no correlation with gender (r =0.085,P ＜ 0.05).For PD patients,HRQOL became impaired with a general score of(44 ± 16).Activities of daily living (60 ± 15),mobility (49 ± 21),emotional well-being (49 ± 28) and stigma (48 ± 46) were the most seriously affected.Females (x2 =-1.821 P ＜ 0.05) and senile bereaved patients (x2 =-1.512,P ＜ 0.05) had significantly lower HRQOL than that of others.For PD patients,the general level of HRQOL was significantly positively associated with disease course (r =0.260,P ＜ 0.05) and severity (r =0.259,P ＜ 0.05).The general level of HRQOL was significantly positively associated with the general level of NMS (r =0.686,P ＜0.01).Conclusion Non-motor symptoms (NMS) are quite common in PD patients.For PD patients,NMS has a more negative impact on HRQOL than other symptoms.
