中华医学杂志
中華醫學雜誌
중화의학잡지
National Medical Journal of China
2014年
11期
844-847
,共4页
李琳%杨龙海%刘宇%赵传多%林冬梅%吴宁%刘向阳%高燕宁
李琳%楊龍海%劉宇%趙傳多%林鼕梅%吳寧%劉嚮暘%高燕寧
리림%양룡해%류우%조전다%림동매%오저%류향양%고연저
肺肿瘤%肿瘤,多原发性%肿瘤转移
肺腫瘤%腫瘤,多原髮性%腫瘤轉移
폐종류%종류,다원발성%종류전이
Lung neoplasms%Neoplasms,multiple primary%Neoplasm metastasis
目的 探讨多原发肺癌(MPLC)的临床特点,为MPLC的正确诊断和治疗提供并积累信息.方法 收集2009年3月至2012年9月期间中国医学科学院肿瘤医院胸外科收治患者的临床资料进行归纳分析.结果 基于术前影像学检查提示MPLC,21例患者均首先接受了外科治疗,手术切除肺内肿瘤病灶共49个.术后被组织病理学检查证实本组21例均为MPLC,均为非小细胞肺癌;其中,肿瘤位于同侧肺者11例,位于双侧肺者10例;肿瘤同时性发生者17例,异时性发生者4例;两灶者14例,三灶者6例,四灶者1例;多发病灶之间组织学类型不同者2例(腺癌与鳞癌、鳞癌与原位癌,各1例),多发病灶之间组织学类型相同者19例(17例腺癌,2例鳞癌).患者中Ⅰ期14例、Ⅱ期2例、Ⅲ期5例.结论 对于影像学检查提示高度怀疑MPLC者,只要患者身体条件允许,建议积极手术切除以求获得最佳疗效;有待建立辅助术前诊断MPLC的影像学标准,研发辅助组织病理学诊断或鉴别MPLC的分子标志.
目的 探討多原髮肺癌(MPLC)的臨床特點,為MPLC的正確診斷和治療提供併積纍信息.方法 收集2009年3月至2012年9月期間中國醫學科學院腫瘤醫院胸外科收治患者的臨床資料進行歸納分析.結果 基于術前影像學檢查提示MPLC,21例患者均首先接受瞭外科治療,手術切除肺內腫瘤病竈共49箇.術後被組織病理學檢查證實本組21例均為MPLC,均為非小細胞肺癌;其中,腫瘤位于同側肺者11例,位于雙側肺者10例;腫瘤同時性髮生者17例,異時性髮生者4例;兩竈者14例,三竈者6例,四竈者1例;多髮病竈之間組織學類型不同者2例(腺癌與鱗癌、鱗癌與原位癌,各1例),多髮病竈之間組織學類型相同者19例(17例腺癌,2例鱗癌).患者中Ⅰ期14例、Ⅱ期2例、Ⅲ期5例.結論 對于影像學檢查提示高度懷疑MPLC者,隻要患者身體條件允許,建議積極手術切除以求穫得最佳療效;有待建立輔助術前診斷MPLC的影像學標準,研髮輔助組織病理學診斷或鑒彆MPLC的分子標誌.
목적 탐토다원발폐암(MPLC)적림상특점,위MPLC적정학진단화치료제공병적루신식.방법 수집2009년3월지2012년9월기간중국의학과학원종류의원흉외과수치환자적림상자료진행귀납분석.결과 기우술전영상학검사제시MPLC,21례환자균수선접수료외과치료,수술절제폐내종류병조공49개.술후피조직병이학검사증실본조21례균위MPLC,균위비소세포폐암;기중,종류위우동측폐자11례,위우쌍측폐자10례;종류동시성발생자17례,이시성발생자4례;량조자14례,삼조자6례,사조자1례;다발병조지간조직학류형불동자2례(선암여린암、린암여원위암,각1례),다발병조지간조직학류형상동자19례(17례선암,2례린암).환자중Ⅰ기14례、Ⅱ기2례、Ⅲ기5례.결론 대우영상학검사제시고도부의MPLC자,지요환자신체조건윤허,건의적겁수술절제이구획득최가료효;유대건립보조술전진단MPLC적영상학표준,연발보조조직병이학진단혹감별MPLC적분자표지.
Objective To explore the clinical characteristics of multiple primary lung cancer (MPLC) and provide potential clues to the early diagnosis and treatment selection of MPLC patients.Methods The clinical data of 21 patients with MPLC confirmed by postoperative histopathology were analyzed retrospectively.Results All the 21 patients received surgery (pulmonary lobectomy or pulmonary wedge resection),and 49 intrapulmonary tumors were resected.The histopathological examination demonstrated that all the 21 cases were MPLC.Among the 21 patients,10 had bilateral lesions in lung and 11 had unilateral lesions; 17 suffered synchronous and 4 suffered metachronous tumors; 14 had double two primary tumors,6 had three primary tumors and 1 had four primary tumors.In these patients,2 had various histological subtypes among their multiple lesions and 19 had same histological subtypes among their multiple tumors; 14 cases with stage Ⅰ disease,stage Ⅱ 2 cases,stage Ⅲ 5 cases.Conclusions For the patients who were detected as MPLC by diagnostic imaging examination,more positive therapeutic decision,such as surgery,could be suggested.The molecular markers should be developed for assisting diagnosis of MPLC.
