CAJ | 학술논문

目的评价羟氯喹对系统性红斑狼疮(SLE)妊娠患者的疗效及安全性.方法对象为北京协和医院风湿免疫科和妇产科在2010年1月至2012年12月诊治的妊娠合并SLE患者,共48例,妊娠前SLE病情稳定和重要脏器功能正常至少6个月,并且停用免疫抑制剂半年以上.所有患者妊娠期间服用泼尼松≤15 mg/d和羟氯喹0.2g/次,2次/d.分析SLE患者妊娠前后的疾病活动情况及妊娠结局.结果 48例中9例(18.8％)在妊娠期间出现SLE疾病活动,2例(4.2％)在妊娠后出现;48例中无死亡者,44例(91.7％)成功妊娠,早产儿12例(27.3％),低体重儿13例(29.6％),新生儿除1例因为早产发育迟缓,其余均未出现生长发育异常及病理情况.所有患者视野及眼底均未见明显异常.结论羟氯喹可能改善SLE患者妊娠及胎儿结局,并对孕妇及胎儿具有良好的安全性,妊娠中后期较易复发,应加强监测随诊.
목적 평개간록규대계통성홍반랑창(SLE)임신환자적료효급안전성.방법 대상위북경협화의원풍습면역과화부산과재2010년1월지2012년12월진치적임신합병SLE환자,공48례,임신전SLE병정은정화중요장기공능정상지소6개월,병차정용면역억제제반년이상.소유환자임신기간복용발니송≤15 mg/d화간록규0.2g/차,2차/d.분석SLE환자임신전후적질병활동정황급임신결국.결과 48례중9례(18.8％)재임신기간출현SLE질병활동,2례(4.2％)재임신후출현;48례중무사망자,44례(91.7％)성공임신,조산인12례(27.3％),저체중인13례(29.6％),신생인제1례인위조산발육지완,기여균미출현생장발육이상급병리정황.소유환자시야급안저균미견명현이상.결론 간록규가능개선SLE환자임신급태인결국,병대잉부급태인구유량호적안전성,임신중후기교역복발,응가강감측수진.
Objective To evaluate the efficacy and safety of hydroxychloroquine (HCQ) in pregnant patients with systemic lupus erythematosus (SLE).Methods A total of 48 pregnant patients with SLE were prospectively recruited from January 2010 to December 2012 at Peking Union Medical College Hospital.Diseases were stable,functions of important organs normal and immunosupressants were discontinued for at least 6 months.Predisone (≤ 15mg qd) and HCQ (0.2 bid) were taken during the whole pregnancy.SLE disease activity before,during and after pregnancy and pregnancy outcome were analyzed.Results SLE relapsed in 9 (18.8％) patients during pregnancy and 2 (4.2％) cases relapsed after delivery.There was no mortality.And 44 cases (91.7％) had successful pregnancy with 12(27.3％) preterm infants and 13(29.6％) infants with low birth weight.All neonates grew healthily,except one with hypoevolutism because of premature growth.Neither visual field nor fundus showed any abnormality.Conclusion HCQ may be effective in improving the pregnancy and fetal outcomes in SLE patients.And it is safe for pregnant women and fetuses.The patients should be regularly monitored and followed up.