中华医学杂志
中華醫學雜誌
중화의학잡지
National Medical Journal of China
2014年
13期
990-993
,共4页
陈旭梅%朱琪玥%张伟%李雪%郝以辉%李幼辉%吕路线%宋学勤
陳旭梅%硃琪玥%張偉%李雪%郝以輝%李幼輝%呂路線%宋學勤
진욱매%주기모%장위%리설%학이휘%리유휘%려로선%송학근
精神分裂症%叶酸%同型半胱氨酸%认知功能
精神分裂癥%葉痠%同型半胱氨痠%認知功能
정신분렬증%협산%동형반광안산%인지공능
Schizophrenia%Folate%Homocysteine%Cognitive function
目的 探讨首发精神分裂症患者血清叶酸、同型半胱氨酸水平及其与认知功能之间的关系.方法 选取2012年10月至2013年6月就诊于郑州大学第一附属医院的60例首发未用药精神分裂症患者(患者组)和同期的健康对照者(对照组)60名,采用电化学免疫发光法和循环酶法分别测定受试者血清叶酸和同型半胱氨酸水平,阳性和阴性症状量表(PANSS)评定患者组入组时精神症状,精神分裂症认知功能成套测验(MCCB)评估患者入组时的认知功能.结果 患者组血清叶酸水平[(4.1 ±1.9) ng/ml]低于对照组[(7.5±1.9)ng/ml] (P ＜0.001);同型半胱氨酸水平患者组[(27 ±9)μmol/L]高于对照组[(18±6)μmol/L] (P =0.006);相关分析显示,患者组叶酸水平和同型半胱氨酸水平呈负相关(r=-0.38,P=0.002),患者组血清叶酸水平与阴性症状呈负相关(r=-0.25,P＜0.05),患者血清同型半胱氨酸水平与连线测验分呈正相关(r=0.28),与霍普金斯词语学习测验分、简易视觉记忆测验分、Stroop色词测验分和持续操作测验评分呈负相关(r=-0.38,r=-0.33,r=-0.30,r=-0.30,均P＜0.05).结论 首发精神分裂症患者血清叶酸水平降低,同型半胱氨酸水平升高,与患者精神症状和认知功能的损害程度存在一定相关性.
目的 探討首髮精神分裂癥患者血清葉痠、同型半胱氨痠水平及其與認知功能之間的關繫.方法 選取2012年10月至2013年6月就診于鄭州大學第一附屬醫院的60例首髮未用藥精神分裂癥患者(患者組)和同期的健康對照者(對照組)60名,採用電化學免疫髮光法和循環酶法分彆測定受試者血清葉痠和同型半胱氨痠水平,暘性和陰性癥狀量錶(PANSS)評定患者組入組時精神癥狀,精神分裂癥認知功能成套測驗(MCCB)評估患者入組時的認知功能.結果 患者組血清葉痠水平[(4.1 ±1.9) ng/ml]低于對照組[(7.5±1.9)ng/ml] (P ＜0.001);同型半胱氨痠水平患者組[(27 ±9)μmol/L]高于對照組[(18±6)μmol/L] (P =0.006);相關分析顯示,患者組葉痠水平和同型半胱氨痠水平呈負相關(r=-0.38,P=0.002),患者組血清葉痠水平與陰性癥狀呈負相關(r=-0.25,P＜0.05),患者血清同型半胱氨痠水平與連線測驗分呈正相關(r=0.28),與霍普金斯詞語學習測驗分、簡易視覺記憶測驗分、Stroop色詞測驗分和持續操作測驗評分呈負相關(r=-0.38,r=-0.33,r=-0.30,r=-0.30,均P＜0.05).結論 首髮精神分裂癥患者血清葉痠水平降低,同型半胱氨痠水平升高,與患者精神癥狀和認知功能的損害程度存在一定相關性.
목적 탐토수발정신분렬증환자혈청협산、동형반광안산수평급기여인지공능지간적관계.방법 선취2012년10월지2013년6월취진우정주대학제일부속의원적60례수발미용약정신분렬증환자(환자조)화동기적건강대조자(대조조)60명,채용전화학면역발광법화순배매법분별측정수시자혈청협산화동형반광안산수평,양성화음성증상량표(PANSS)평정환자조입조시정신증상,정신분렬증인지공능성투측험(MCCB)평고환자입조시적인지공능.결과 환자조혈청협산수평[(4.1 ±1.9) ng/ml]저우대조조[(7.5±1.9)ng/ml] (P ＜0.001);동형반광안산수평환자조[(27 ±9)μmol/L]고우대조조[(18±6)μmol/L] (P =0.006);상관분석현시,환자조협산수평화동형반광안산수평정부상관(r=-0.38,P=0.002),환자조혈청협산수평여음성증상정부상관(r=-0.25,P＜0.05),환자혈청동형반광안산수평여련선측험분정정상관(r=0.28),여곽보금사사어학습측험분、간역시각기억측험분、Stroop색사측험분화지속조작측험평분정부상관(r=-0.38,r=-0.33,r=-0.30,r=-0.30,균P＜0.05).결론 수발정신분렬증환자혈청협산수평강저,동형반광안산수평승고,여환자정신증상화인지공능적손해정도존재일정상관성.
Objective To explore the correlation between serum levels of homocysteine (Hcy) and folate and cognitive function in first-episode drug-naǐve schizophrenics.Methods A total of 60 first-episode schizophrenics (schizophrenia group) from our hospital and 60 healthy individuals (control group) were enrolled.Serum levels of folate and Hcy were measured with electrochemical luminescence method and enzymatic cycling assay respectively.Positive and Negative Syndrome Scale (PANSS) was used to evaluate the mental symptoms and Matrics Consensus Cognitive Battery (MCCB) was used to evaluate the cognitive function.Results Serum level of folate in schizophrenia group (4.1 ± 1.9 ng/ml) was lower than that in control group (7.5 ± 1.9 ng/ml) (P ＜ 0.001).And serum level of Hcy in schizophrenia group (27 ± 9 μmol/L) was significantly higher than that in control group (18 ± 6 μmol/L) (P =0.006).Serum level of folate in schizophrenia group had negative correlations with Hcy level (r =-0.38,P =0.002) and negative symptoms (r =-0.25,P ＜ 0.05) while Hcy level was negatively correlated with cognitive function scores (r=-0.38,r =-0.33,r =-0.30,r =-0.30,P ＜0.05).Conclusion Serum level of folate decreases while serum level of Hcy increases in first-episode schizophrenics.Both have some relevance with mental symptom and cognitive dysfunction.
