中华医学杂志
中華醫學雜誌
중화의학잡지
National Medical Journal of China
2014年
15期
1139-1142
,共4页
急性下壁ST段抬高性心肌梗死%前壁导联ST压低%血浆炎症因子
急性下壁ST段抬高性心肌梗死%前壁導聯ST壓低%血漿炎癥因子
급성하벽ST단태고성심기경사%전벽도련ST압저%혈장염증인자
Inferior ST-segment elevation acute myocardial infarction%Anterior ST-segment depression%Plasma inflammatory cytokines
目的 分析炎性因子水平与急性下壁心肌梗死有无前壁导联ST段压低之间的相关性及其临床意义.方法 选取北京安贞医院2007年5月至2012年9月急诊危重症中心因急性下壁ST段抬高性心肌梗死入院的患者360例,所有患者均急诊行PCI治疗,并观察罪犯血管以外冠脉病变的情况.所有患者根据有无前壁导联ST压低分为对照组180例和前壁ST段压低组180例.所有患者均于入院即刻取静脉血8ml,分离血浆,通过生物化学和ELISA方法检测血浆超敏C反应蛋白(Hs-CRP)、纤维蛋白原(Fib)、白细胞介素6(IL-6)、肿瘤坏死因子(TNF-α)、丙二醛(MDA)、过氧化物岐化酶(SOD)的变化,并分析血浆炎性因子水平与有无前壁ST段压低急性下壁心肌梗死相关性.结果 与对照组比较,前壁导联ST段压低患者双支病变、3支病变的比例更高(P＜0.01);血浆Hs-CRP、Fib、IL-6、TNF-α水平升高更显著(P＜0.01),脂质过氧化产物MDA含量更高(P＜0.01),抗氧化物质SOD含量更低(P＜0.01).结论 血浆炎症因子及脂质过氧化程度可在一定程度上反映冠脉病变的程度,对疾病的严重程度具有一定的预测价值.
目的 分析炎性因子水平與急性下壁心肌梗死有無前壁導聯ST段壓低之間的相關性及其臨床意義.方法 選取北京安貞醫院2007年5月至2012年9月急診危重癥中心因急性下壁ST段抬高性心肌梗死入院的患者360例,所有患者均急診行PCI治療,併觀察罪犯血管以外冠脈病變的情況.所有患者根據有無前壁導聯ST壓低分為對照組180例和前壁ST段壓低組180例.所有患者均于入院即刻取靜脈血8ml,分離血漿,通過生物化學和ELISA方法檢測血漿超敏C反應蛋白(Hs-CRP)、纖維蛋白原(Fib)、白細胞介素6(IL-6)、腫瘤壞死因子(TNF-α)、丙二醛(MDA)、過氧化物岐化酶(SOD)的變化,併分析血漿炎性因子水平與有無前壁ST段壓低急性下壁心肌梗死相關性.結果 與對照組比較,前壁導聯ST段壓低患者雙支病變、3支病變的比例更高(P＜0.01);血漿Hs-CRP、Fib、IL-6、TNF-α水平升高更顯著(P＜0.01),脂質過氧化產物MDA含量更高(P＜0.01),抗氧化物質SOD含量更低(P＜0.01).結論 血漿炎癥因子及脂質過氧化程度可在一定程度上反映冠脈病變的程度,對疾病的嚴重程度具有一定的預測價值.
목적 분석염성인자수평여급성하벽심기경사유무전벽도련ST단압저지간적상관성급기림상의의.방법 선취북경안정의원2007년5월지2012년9월급진위중증중심인급성하벽ST단태고성심기경사입원적환자360례,소유환자균급진행PCI치료,병관찰죄범혈관이외관맥병변적정황.소유환자근거유무전벽도련ST압저분위대조조180례화전벽ST단압저조180례.소유환자균우입원즉각취정맥혈8ml,분리혈장,통과생물화학화ELISA방법검측혈장초민C반응단백(Hs-CRP)、섬유단백원(Fib)、백세포개소6(IL-6)、종류배사인자(TNF-α)、병이철(MDA)、과양화물기화매(SOD)적변화,병분석혈장염성인자수평여유무전벽ST단압저급성하벽심기경사상관성.결과 여대조조비교,전벽도련ST단압저환자쌍지병변、3지병변적비례경고(P＜0.01);혈장Hs-CRP、Fib、IL-6、TNF-α수평승고경현저(P＜0.01),지질과양화산물MDA함량경고(P＜0.01),항양화물질SOD함량경저(P＜0.01).결론 혈장염증인자급지질과양화정도가재일정정도상반영관맥병변적정도,대질병적엄중정도구유일정적예측개치.
Objective To investigate the level of Hs-CRP,Fib,IL-6,TNF-α,MDA,SOD,and analyse the correlation between the level of plasma inflammatory cytokines and clinical significance in patients with anterior ST-segment depression.Methods We choosed 360 patients with inferior ST Segment elavation acute myocardial infarction from May 2007 to Sep 2012 in rescue Center of Anzhen Hospital,in Anzhen Hospital,and all the patients received percutaneous coronary intervention treatment and the vascular lesions besides culprit vessel were observed.All the patients were divided into two groups:control group(n =180) and anterior ST-segment depression group (n =180).8ml venous blood was obtained from all the patients,and then plasma were separated.The level of plasma Hs-CRP,Fib,IL-6,TNF-αt,MDA,SOD were investigated by Biochemistry and ELISA.And the relativity between the level of plasma inflammatory cytokines and anterior ST-segment depression in patients with inferior acute myocardial infarction was analysed.Results The proportion of double vessel coronary disease,three coronary artery lesion is higher in anterior ST-segment depression group compared with control group(P ＜ 0.01).Compared with control group,the level of Hs-CRP,Fib,IL-6,TNF-α,MDA,SOD of anterior ST-segment depression group are inclined signifancantly(P ＜ 0.01).Conclusion The level of plasma inflammatory cytokines and the degree of lipid peroxidation can reflect the severity of coronary artery disease and may have certain value in predicting the severity of disease.
