中华医学杂志
中華醫學雜誌
중화의학잡지
National Medical Journal of China
2014年
16期
1252-1254
,共3页
甘辉立%张健群%冯磊%张志泰%梁林%朱光发%陈东
甘輝立%張健群%馮磊%張誌泰%樑林%硃光髮%陳東
감휘립%장건군%풍뢰%장지태%량림%주광발%진동
肺肿瘤%诊断%外科治疗
肺腫瘤%診斷%外科治療
폐종류%진단%외과치료
Lung neoplasms%Diagnosis%Surgical treatment
目的 比较分析肺动脉肉瘤(PAS)的临床影像学特征和外科治疗效果.方法 回顾性分析2001年11月至2014年1月安贞医院心脏外科中心收治19例PAS的诊断和治疗结果.结果 19例患者的肺动脉CT血管造影(CTA)均显示蚀壁征;14例手术后病理学检查证实为PAS;5例未行手术治疗者PET-CT检查显示氟脱氧葡萄糖摄取异常增高团块影.14例手术中,肺动脉内膜剥脱术12例,一侧全肺切除2例;5例未手术.手术患者无围手术期死亡.5例未手术患者出院后平均生存(20.3 ±ll.2)d,14例手术患者术后平均生存(16.8±3.8)个月,差异有统计学意义(P=0.000).不同术式和不同病理分型的PAS生存时间差异均无统计学意义.9例未行辅助性放疗化疗患者生存时间为(12.3±3.2)个月,5例行辅助性放疗化疗患者生存时间为(22.8±4.3)个月,差异有统计学意义(P =0.000).结论 “蚀壁征”具有PAS疾病特征性;外科手术治疗可延长PAS的生存期,辅助性化疗和放疗可进一步延长患者的生存期.
目的 比較分析肺動脈肉瘤(PAS)的臨床影像學特徵和外科治療效果.方法 迴顧性分析2001年11月至2014年1月安貞醫院心髒外科中心收治19例PAS的診斷和治療結果.結果 19例患者的肺動脈CT血管造影(CTA)均顯示蝕壁徵;14例手術後病理學檢查證實為PAS;5例未行手術治療者PET-CT檢查顯示氟脫氧葡萄糖攝取異常增高糰塊影.14例手術中,肺動脈內膜剝脫術12例,一側全肺切除2例;5例未手術.手術患者無圍手術期死亡.5例未手術患者齣院後平均生存(20.3 ±ll.2)d,14例手術患者術後平均生存(16.8±3.8)箇月,差異有統計學意義(P=0.000).不同術式和不同病理分型的PAS生存時間差異均無統計學意義.9例未行輔助性放療化療患者生存時間為(12.3±3.2)箇月,5例行輔助性放療化療患者生存時間為(22.8±4.3)箇月,差異有統計學意義(P =0.000).結論 “蝕壁徵”具有PAS疾病特徵性;外科手術治療可延長PAS的生存期,輔助性化療和放療可進一步延長患者的生存期.
목적 비교분석폐동맥육류(PAS)적림상영상학특정화외과치료효과.방법 회고성분석2001년11월지2014년1월안정의원심장외과중심수치19례PAS적진단화치료결과.결과 19례환자적폐동맥CT혈관조영(CTA)균현시식벽정;14례수술후병이학검사증실위PAS;5례미행수술치료자PET-CT검사현시불탈양포도당섭취이상증고단괴영.14례수술중,폐동맥내막박탈술12례,일측전폐절제2례;5례미수술.수술환자무위수술기사망.5례미수술환자출원후평균생존(20.3 ±ll.2)d,14례수술환자술후평균생존(16.8±3.8)개월,차이유통계학의의(P=0.000).불동술식화불동병리분형적PAS생존시간차이균무통계학의의.9례미행보조성방료화료환자생존시간위(12.3±3.2)개월,5례행보조성방료화료환자생존시간위(22.8±4.3)개월,차이유통계학의의(P =0.000).결론 “식벽정”구유PAS질병특정성;외과수술치료가연장PAS적생존기,보조성화료화방료가진일보연장환자적생존기.
Objective To characterize the differential diagnostic characteristics and the surgical treatment efficacy of pulmonary artery sarcoma (PAS).Methods From November 2001 to January 2014,19 PAS patients were diagnosed and 14 of them underwent surgery at Beijing Anzhen Hospital.And their data were retrospectively reviewed.Results All 19 patients underwent pulmonary artery computed tomography angiography (CTA) scan.All showed a filling defect within the lumen of pulmonary artery with a sign of wall eclipsing.And 14 of them had pulmonary artery sarcoma confirmed through postoperative histopathological examination while another 5 patients were confirmed to have FDG abnormal high intake mass shadow on Positron emission tomography-computed tomography (PET-CT) scan.Fourteen patients underwent surgery,including pulmonary endarterectomy (n =12) and pneumonectomy (n =2),and another five had no indication for operation and died shortly.No perioperative death occurred for surgical patients.Five non-surgical patients survived (20.3 ± 11.2) days after discharge.And 14 postoperative patients survived (16.8 ± 3.8) months.The difference between two groups reached statistical significance (P =0.000).The survival difference between two surgical procedures and between two pathological classifications did not reach statistical significance.Nine patients did not while another 5 received adjuvant radiotherapy and chemotherapy.Their average survivals were (12.3 ± 3.2) and (22.8 ± 4.3) months respectively.And the inter-group difference reached statistical significance (P =0.000).Conclusions The sign of wall eclipsing on pulmonary artery CTA scan is pathognomonic for PAS.Radical surgical resection provides a longer survival than non-surgery and adjuvant chemotherapy may further extend survival.