CAJ | 학술논문

目的探讨血清adropin蛋白水平与冠心病的相关性.方法选择2011年1月至2012年7月因胸痛、胸闷首次于苏州大学附属第二医院就诊的患者356例,根据冠状动脉造影结果分为冠心病组(264例)与对照组(92例).测定血清adropin、高敏C反应蛋白、空腹血糖、空腹血浆胰岛素浓度.冠心病组患者计算SYNTAX得分.结果冠心病组患者的血清adropin浓度明显低于对照组[(56±15)比(83±10) ng/L,P＜0.01].SYNTAX低分组、中分组、高分组患者的血清adropin浓度分别为(60±22)、(56±12)、(54±10) ng/L,3组间差异无统计学意义(P=0.116).多因素Logistic回归分析显示低血清adropin水平是冠心病发病的独立危险因素(OR=0.849,95％ CI:0.817～0.882,P＜0.01).结论低血清adropin水平与冠心病具有相关性,adropin可能在冠心病的发病中起保护作用.
목적 탐토혈청adropin단백수평여관심병적상관성.방법 선택2011년1월지2012년7월인흉통、흉민수차우소주대학부속제이의원취진적환자356례,근거관상동맥조영결과분위관심병조(264례)여대조조(92례).측정혈청adropin、고민C반응단백、공복혈당、공복혈장이도소농도.관심병조환자계산SYNTAX득분.결과 관심병조환자적혈청adropin농도명현저우대조조[(56±15)비(83±10) ng/L,P＜0.01].SYNTAX저분조、중분조、고분조환자적혈청adropin농도분별위(60±22)、(56±12)、(54±10) ng/L,3조간차이무통계학의의(P=0.116).다인소Logistic회귀분석현시저혈청adropin수평시관심병발병적독립위험인소(OR=0.849,95％ CI:0.817～0.882,P＜0.01).결론 저혈청adropin수평여관심병구유상관성,adropin가능재관심병적발병중기보호작용.
Objective To explore the correlation of serum adropin level with coronary artery disease (CAD).Methods According to coronary angiography,356 consecutive patients with chest complaints from January 2011 to July 2012 were divided into 2 groups of CAD (n =264,with CAD) and control (n =92,without CAD).The serum adropin level and other CAD related metabolic parameters were measured and SYNTAX score was calculated.Results Serum adropin level was significantly lower in group CAD than that in control group ((56 ± 15) vs (83 ± 10) ng/L,P ＜ 0.01).Serum adropin levels in high,mild,low SYNTAX score group were (60 ± 22),(56 ± 12),(54 ± 10) ng/L respectively,and there was no significant difference among 3 groups(P =0.116).Multivariate regression analysis revealed that adropin was an independent risk factor for CAD (OR =0.849,95％ CI:0.817-0.882,P ＜0.01).Conclusions Lower serum adropin level is significantly associated with CAD.Thus it indicates a possible role of adropin in the prevention of CAD.