CAJ | 학술논문

目的探讨青少年近视患者血清性激素的变化.方法 2013年1月在温州瓯海区某中学调查822例学生,其中男生432例,女生390例,设视力≥5.0为正常,分为近视组与非近视组,再用化学发光免疫分析仪分别检测上述2组青少年空腹血清的雌二醇(E2)、睾丸酮(T)、促卵泡刺激素(FSH)、黄体生成素(LH)4项性激素浓度.结果男性、女性促卵泡刺激素水平差异有统计学意义(Z=12.9,P＜0.01),同时结合二者的平均水平,判断女性(均值为6.87)高于男性(均值为5.06);男性、女性促黄体生成素差异有统计学意义(Z=9.3,P＜0.01),同时结合二者的平均水平,判断女性(均值为7.39)显著高于男性(均值为1.96).女性近视与非近视两组促黄体生成素水平差异有统计学意义(Z=-2.45,P＜0.05),同时结合两组的均值水平,判断近视组(均值为8.21)大于非近视组(均值为5.54);女性近视与非近视两组促卵泡刺激素水平差异性有统计学意义(Z=-2.91,P＜0.05),同时结合两组的均值水平,判断近视组(均值为7.27)大于非近视组(均值为5.96).男性近视组与非近视组间促黄体生成素水平差异有统计学意义(Z=-2.84,P＜0.01),同时结合两组的均值水平,判断近视组(均值为2.06)大于非近视组(均值为1.78);两组睾丸酮水平差异有统计学意义(Z=-2.6,P＜0.01),同时结合两组的均值水平,判断近视组(均值为2.11)大于非近视组(均值为1.79).结论血清中性激素水平的高低及性别差异与青少年近视的发生与发展可能存在一定关联.
목적 탐토청소년근시환자혈청성격소적변화.방법 2013년1월재온주구해구모중학조사822례학생,기중남생432례,녀생390례,설시력≥5.0위정상,분위근시조여비근시조,재용화학발광면역분석의분별검측상술2조청소년공복혈청적자이순(E2)、고환동(T)、촉란포자격소(FSH)、황체생성소(LH)4항성격소농도.결과 남성、녀성촉란포자격소수평차이유통계학의의(Z=12.9,P＜0.01),동시결합이자적평균수평,판단녀성(균치위6.87)고우남성(균치위5.06);남성、녀성촉황체생성소차이유통계학의의(Z=9.3,P＜0.01),동시결합이자적평균수평,판단녀성(균치위7.39)현저고우남성(균치위1.96).녀성근시여비근시량조촉황체생성소수평차이유통계학의의(Z=-2.45,P＜0.05),동시결합량조적균치수평,판단근시조(균치위8.21)대우비근시조(균치위5.54);녀성근시여비근시량조촉란포자격소수평차이성유통계학의의(Z=-2.91,P＜0.05),동시결합량조적균치수평,판단근시조(균치위7.27)대우비근시조(균치위5.96).남성근시조여비근시조간촉황체생성소수평차이유통계학의의(Z=-2.84,P＜0.01),동시결합량조적균치수평,판단근시조(균치위2.06)대우비근시조(균치위1.78);량조고환동수평차이유통계학의의(Z=-2.6,P＜0.01),동시결합량조적균치수평,판단근시조(균치위2.11)대우비근시조(균치위1.79).결론 혈청중성격소수평적고저급성별차이여청소년근시적발생여발전가능존재일정관련.
Objective To investigate the quantitative changes of the serum sex hormone levels in juvenile myopia patients.Methods In January 2013,investigation of wenzhou middle school 822 adolescents,including 432 male patients and 390 female patients were involved in the study Visual acuity ≥ 5 was set as the normal value.The subjects were divided into two groups,the myopia group and the non-myopia group.Chemiluminescence immunoassay analyzer was used to detect the subjects' sex hormone concentration of estradiol (E2),testosterone (T),follicle stimulating hormone (FSH) and luteinizing hormone (LH).Results The follicle stimulating hormone and luteinizing hormone of the female patients were significantly higher than those of male counterparts (P ＜ 0.01) ; among the two groups consisting female myopia and non-myopia patients,a significant difference in luteinizing hormone and follicle stimulating hormone was shown (P ＜ 0.05) ; the distinct differences in the level of luteinizing hormone and testosterone level showed in the male myopia group and non-myopia group were of outstanding statistics significance (P ＜0.01),showing the result that the level of sex hormone in myopia group was higher than that in the non-myopia group.Conclusion A close relationship perhaps between the level of sex hormone with gender differences and juvenile myopia is confirmed.