中华医学杂志
中華醫學雜誌
중화의학잡지
National Medical Journal of China
2014年
20期
1530-1533
,共4页
李嘉璐%黄毓%杨定华%梁博%何华%廖辉%郭柏棠%刘新成%林梁
李嘉璐%黃毓%楊定華%樑博%何華%廖輝%郭柏棠%劉新成%林樑
리가로%황육%양정화%량박%하화%료휘%곽백당%류신성%림량
癌,肝细胞%NVM-1,人%复发%肿瘤转移
癌,肝細胞%NVM-1,人%複髮%腫瘤轉移
암,간세포%NVM-1,인%복발%종류전이
Carcinoma,hepatocellular%Novel metastasis-promoting gene 1 protein,human%Recurrence%Neoplasm metastasis
目的 观察NVM-1(Novel metastasis-promoting gene 1)蛋白在肝细胞癌(HCC)中的表达情况及意义.方法 应用免疫组化SP法检测92例HCC癌组织及非癌组织中NVM-1蛋白的表达水平,并分析其与HCC临床病理因素的相关性.结果 NVM-1蛋白主要定位在癌组织的细胞核,NVM-1蛋白在癌组织中阳性表达率(52.2％)高于非癌组织(28.3％)及肝脏良性病变的肝脏组织(0),差异有统计学意义(P＜0.05).NVM-1蛋白的表达与肿瘤的TNM分期(P=0.016)、BCLC分期(P=0.015)、病理分化程度(P =0.000)、肝内转移(P =0.002)、门脉癌栓(P=0.023)、复发(P=0.001)显著相关,但与HBV、肿瘤大小、个数、肝硬化等无相关性;Kaplan-Meier分析显示癌组织NVM-1表达阳性组中位无瘤生存时间为5个月,NVM-1表达阴性组中位无瘤生存时间为13个月,两者差异有统计学意义(P=0.001).结论 HCC癌组织中NVM-1的阳性表达可能与肿瘤的转移复发有密切关系.
目的 觀察NVM-1(Novel metastasis-promoting gene 1)蛋白在肝細胞癌(HCC)中的錶達情況及意義.方法 應用免疫組化SP法檢測92例HCC癌組織及非癌組織中NVM-1蛋白的錶達水平,併分析其與HCC臨床病理因素的相關性.結果 NVM-1蛋白主要定位在癌組織的細胞覈,NVM-1蛋白在癌組織中暘性錶達率(52.2％)高于非癌組織(28.3％)及肝髒良性病變的肝髒組織(0),差異有統計學意義(P＜0.05).NVM-1蛋白的錶達與腫瘤的TNM分期(P=0.016)、BCLC分期(P=0.015)、病理分化程度(P =0.000)、肝內轉移(P =0.002)、門脈癌栓(P=0.023)、複髮(P=0.001)顯著相關,但與HBV、腫瘤大小、箇數、肝硬化等無相關性;Kaplan-Meier分析顯示癌組織NVM-1錶達暘性組中位無瘤生存時間為5箇月,NVM-1錶達陰性組中位無瘤生存時間為13箇月,兩者差異有統計學意義(P=0.001).結論 HCC癌組織中NVM-1的暘性錶達可能與腫瘤的轉移複髮有密切關繫.
목적 관찰NVM-1(Novel metastasis-promoting gene 1)단백재간세포암(HCC)중적표체정황급의의.방법 응용면역조화SP법검측92례HCC암조직급비암조직중NVM-1단백적표체수평,병분석기여HCC림상병리인소적상관성.결과 NVM-1단백주요정위재암조직적세포핵,NVM-1단백재암조직중양성표체솔(52.2％)고우비암조직(28.3％)급간장량성병변적간장조직(0),차이유통계학의의(P＜0.05).NVM-1단백적표체여종류적TNM분기(P=0.016)、BCLC분기(P=0.015)、병리분화정도(P =0.000)、간내전이(P =0.002)、문맥암전(P=0.023)、복발(P=0.001)현저상관,단여HBV、종류대소、개수、간경화등무상관성;Kaplan-Meier분석현시암조직NVM-1표체양성조중위무류생존시간위5개월,NVM-1표체음성조중위무류생존시간위13개월,량자차이유통계학의의(P=0.001).결론 HCC암조직중NVM-1적양성표체가능여종류적전이복발유밀절관계.
Objective To explore the expression of NVM-1 (novel metastasis-promoting gene 1) in hepatocellular carcinoma (HCC) tissue and examine its clinical significance.Methods The expression of NVM-1 in 92 cases of HCC tumor tissues and non-tumor tissues was detected by immunohistochemical staining with SP (streptavidin-perosidase).And its clinical significance was evaluated.Results The staining of NVM-1 was predominantly located in the nucleus of HCC tumor tissue.The positive rate of NVM-1 was 52.2％ in all detected cancers and it was higher than that in control non-tumor tissues(28.3％) and benign hepatic lesions (0).A significant difference of positive rates existed between tumor and nontumor tissues (P ＜ 0.05).The expression of NVM-1 in HCC was not correlated with hepatic B virus (HBV),size,amount or cirrhosis,etc.However,it was correlated with TNM (P =0.016),BCLC stage (P =0.015),poor differentiation (P =0.000),intrahepatic metastasis (P =0.002),portal vein tumor thrombus (P =0.023) and recurrence (P =0.001).By Kaplan-Meier analysis,the median tumor-free survival time was 5 months in positive expression group and it was significantly shorter than 13 months in negative expression group (P =0.001).Conclusion There is probably a close relation between recurrence and metastasis and the expression of NVM-1 in HCC.
