CAJ | 학술논문

SELEX是一种新近发展起来的组合生物化学技术,即通过配基识别、结合目的靶分子从而筛选出特定靶分子的高特异性和高亲和力的配基.针对筛选获得的特异配基在临床上有多种应用,如应用于疾病的临床诊断,作为功能阻断物质开发新型的治疗药物,或直接参与阻断疾病的进程应用于临床治疗等.
SELEX시일충신근발전기래적조합생물화학기술,즉통과배기식별、결합목적파분자종이사선출특정파분자적고특이성화고친화력적배기.침대사선획득적특이배기재림상상유다충응용,여응용우질병적림상진단,작위공능조단물질개발신형적치료약물,혹직접삼여조단질병적진정응용우림상치료등.
SELEX is a newly developed biochemical technique,which filter out high specificity and high affinity ligand for the target molecules through the identification of aptamer combined with the target molecules.The specific aptamer was used in a variety of clinical applications,such as diagnosis of the disease,development of new therapeutic drugs and even directly applied to disease treatment.