CAJ | 학술논문

持留菌的存在是导致细菌清除不完全,治疗失败的重要原因之一,应该引起广大医务工作者关注.持留菌是一类与种群内普通细菌、耐药菌特征不同的特殊亚群,近年来随着学科的交叉与研究的拓展,对持留菌的认识取得突破性进展.本文从持留菌的特点、形成机制、对临床治疗的影响以及针对持留菌的药物研发等几个方面加以概述,为诊断、预防和治疗持留茵相关感染提供依据.
지류균적존재시도치세균청제불완전,치료실패적중요원인지일,응해인기엄대의무공작자관주.지류균시일류여충군내보통세균、내약균특정불동적특수아군,근년래수착학과적교차여연구적탁전,대지류균적인식취득돌파성진전.본문종지류균적특점、형성궤제、대림상치료적영향이급침대지류균적약물연발등궤개방면가이개술,위진단、예방화치료지류인상관감염제공의거.
Persister bacteria have the characteristic of phenotypic resistance to the anfimicrobial drugs.The presence of such persister bacteria is considered to be one of the major causes for lengthy therapy and treatment failure.Persister bacteria are a group of special subpopulation of bacteria,and have the characteristics different from the ordinary bacteria and resistant mutants.With the improvement of scientific research and technology in recent years,we get a better understanding of persister bacteria.This paper reviewed the research progress on the characteristics of persister bacteria,formation mechanism,the impact of the clinical treatment and drug development The paper also provided the basis for diagnosis,prevention and treatment of the persister bacteria.