中华检验医学杂志
中華檢驗醫學雜誌
중화검험의학잡지
CHINESE JOURNAL OF LABORATORY MEDICINE
2013年
10期
912-915
,共4页
黄惠敏%韦妮莉%罗文婷%郑佩燕%孙宝清
黃惠敏%韋妮莉%囉文婷%鄭珮燕%孫寶清
황혜민%위니리%라문정%정패연%손보청
食物过敏%免疫球蛋白E%变应原
食物過敏%免疫毬蛋白E%變應原
식물과민%면역구단백E%변응원
Food hypersensitivity%Immunoglobulin E%Allergens
目的 探讨广州医科大学附属第一医院门诊怀疑食物过敏患者常见食物过敏原sIgE阳性分布特征及过敏原间的相关性.方法 采用回顾性调查研究的方法,选取2006年7月至2013年1月在我院就诊怀疑食物过敏的854例患者,使用荧光酶联免疫吸附法对其血清进行7种食物过敏原(牛奶、蛋清、蛋黄、虾、蟹、花生和大豆)sIgE抗体检测.采用SPSS 19.0统计软件进行数据处理,采用x2检验比较各过敏原sIgE组问阳性率差异.结果 7种食物过敏原的阳性率分别是39.3％(283/720)、36.3％(216/595)、9.8％(28/285)、21.2％(36/170)、24.3％ (17/70)、14.8％ (9/61)和10.0％ (5/50).在同时检测蛋清和蛋黄sIgE的282例患者中,蛋清sIgE阳性率[59.6％(168/282)]远高于蛋黄阳性率[9.2％ (26/282)],差异有统计学意义(x2=138.1,P＜0.01).不同年龄组间阳性率不同(牛奶x2 =792.88,蛋清x2=658.21,P均＜0.01),随着年龄的增长,牛奶和蛋清sIgE阳性率均呈下降趋势,而且牛奶和蛋清sIgE 4级及以上患者只占阳性患者的1.08％ (2/186)和1.12％(2/178).在同时检测528例患者牛奶和蛋清两种sIgE中,两者同时阳性为26.9％(142/528),两者血清sIgE水平中度相关(rs=0.758,P＜0.01).同时检测64例患者虾和蟹的sIgE,两者同时阳性16例,两者血清sIgE水平高度相关(rs=0.973,P＜0.01)；同时检测34例患者花生和大豆sIgE,两者同时阳性2例,两者血清sIgE水平高度相关(rs=0.879,P＜0.01).结论 蛋清是鸡蛋过敏的主要过敏原.虾和蟹,花生和大豆的sIgE相关性极高,可能因为具有同源性的缘故；蛋清和牛奶虽然不是同源食物,但两者血清sIgE水平呈中度相关,提示患者常常会对牛奶和蛋清存在共同致敏.
目的 探討廣州醫科大學附屬第一醫院門診懷疑食物過敏患者常見食物過敏原sIgE暘性分佈特徵及過敏原間的相關性.方法 採用迴顧性調查研究的方法,選取2006年7月至2013年1月在我院就診懷疑食物過敏的854例患者,使用熒光酶聯免疫吸附法對其血清進行7種食物過敏原(牛奶、蛋清、蛋黃、蝦、蟹、花生和大豆)sIgE抗體檢測.採用SPSS 19.0統計軟件進行數據處理,採用x2檢驗比較各過敏原sIgE組問暘性率差異.結果 7種食物過敏原的暘性率分彆是39.3％(283/720)、36.3％(216/595)、9.8％(28/285)、21.2％(36/170)、24.3％ (17/70)、14.8％ (9/61)和10.0％ (5/50).在同時檢測蛋清和蛋黃sIgE的282例患者中,蛋清sIgE暘性率[59.6％(168/282)]遠高于蛋黃暘性率[9.2％ (26/282)],差異有統計學意義(x2=138.1,P＜0.01).不同年齡組間暘性率不同(牛奶x2 =792.88,蛋清x2=658.21,P均＜0.01),隨著年齡的增長,牛奶和蛋清sIgE暘性率均呈下降趨勢,而且牛奶和蛋清sIgE 4級及以上患者隻佔暘性患者的1.08％ (2/186)和1.12％(2/178).在同時檢測528例患者牛奶和蛋清兩種sIgE中,兩者同時暘性為26.9％(142/528),兩者血清sIgE水平中度相關(rs=0.758,P＜0.01).同時檢測64例患者蝦和蟹的sIgE,兩者同時暘性16例,兩者血清sIgE水平高度相關(rs=0.973,P＜0.01)；同時檢測34例患者花生和大豆sIgE,兩者同時暘性2例,兩者血清sIgE水平高度相關(rs=0.879,P＜0.01).結論 蛋清是鷄蛋過敏的主要過敏原.蝦和蟹,花生和大豆的sIgE相關性極高,可能因為具有同源性的緣故；蛋清和牛奶雖然不是同源食物,但兩者血清sIgE水平呈中度相關,提示患者常常會對牛奶和蛋清存在共同緻敏.
목적 탐토엄주의과대학부속제일의원문진부의식물과민환자상견식물과민원sIgE양성분포특정급과민원간적상관성.방법 채용회고성조사연구적방법,선취2006년7월지2013년1월재아원취진부의식물과민적854례환자,사용형광매련면역흡부법대기혈청진행7충식물과민원(우내、단청、단황、하、해、화생화대두)sIgE항체검측.채용SPSS 19.0통계연건진행수거처리,채용x2검험비교각과민원sIgE조문양성솔차이.결과 7충식물과민원적양성솔분별시39.3％(283/720)、36.3％(216/595)、9.8％(28/285)、21.2％(36/170)、24.3％ (17/70)、14.8％ (9/61)화10.0％ (5/50).재동시검측단청화단황sIgE적282례환자중,단청sIgE양성솔[59.6％(168/282)]원고우단황양성솔[9.2％ (26/282)],차이유통계학의의(x2=138.1,P＜0.01).불동년령조간양성솔불동(우내x2 =792.88,단청x2=658.21,P균＜0.01),수착년령적증장,우내화단청sIgE양성솔균정하강추세,이차우내화단청sIgE 4급급이상환자지점양성환자적1.08％ (2/186)화1.12％(2/178).재동시검측528례환자우내화단청량충sIgE중,량자동시양성위26.9％(142/528),량자혈청sIgE수평중도상관(rs=0.758,P＜0.01).동시검측64례환자하화해적sIgE,량자동시양성16례,량자혈청sIgE수평고도상관(rs=0.973,P＜0.01)；동시검측34례환자화생화대두sIgE,량자동시양성2례,량자혈청sIgE수평고도상관(rs=0.879,P＜0.01).결론 단청시계단과민적주요과민원.하화해,화생화대두적sIgE상관성겁고,가능인위구유동원성적연고；단청화우내수연불시동원식물,단량자혈청sIgE수평정중도상관,제시환자상상회대우내화단청존재공동치민.
Objective To explore the positive distribution characteristics and analyse the correlation of common food allergen-specific immunoglobulin E (sIgE) with suspected food allergy in the First Affiliated Hospital of Guangzhou Medical University.Methods Using fluorescence enzyme-linked immunosorbent assay to detect the serum sIgE antibody of 854 patients,including 7 kinds of food allergens (milk,egg white,egg yolk,shrimp,crab,peanut and soybean) from July 2006 to January 2013.Data were processed by statistical software SPSS19.0.Results The positive rates of the 7 kinds of food allergen were 39.3％ (283/720),36.3％ (216/595),9.8％ (28/285),21.2％ (36/170),24.3％ (17/70),14.8％ (9/61) and 10.0％ (5/50).Two hundred and eighty-two patients were detected egg white and egg yolk sIgE,the positive rate of egg white sIgE 59.6％ (168/282) was much higher than the egg yolk sIgE 9.2％ (26/282).The positive rate of the milk and egg white sIgE were different between the age groups and decreased with the age(milk:x2 =792.88;egg white:x2 =658.21,P ＜ 0.01).The degree in level 4 or above of milk and egg white sIgE were 1.08％ (2/186) and 1.12％ (2/178) in positive patients.Five hundred and twenty-eight patients were detected milk and egg white sIgE,26.9％ (142/528) were both positive,sIgE levels in serum of them was moderately correlated (rs =0.758,P ＜ 0.01).Serum sIgE of shrimp and crab was detected in 64 patients,16 cases was positive of the shrimp,17 cases of the crab was positive,both positive in 16 cases,sIgE levels in serum of them were highly correlated (rs =0.973,P ＜0.01).In the simultaneous detection of 34 patients' serum sIgE of peanut and soybean,peanut was positive in 4 cases,soybean was positive in 3 cases,both positive in 2 cases,sIgE levels in serum of them were highly correlated (rs =0.879,P ＜ 0.01).Conclusions Egg white is the major allergen of egg allergy.The correlations of shrimp and crab,peanut and soybean are extremely high,probably because of their homology; egg white and milk are not homologous food,but the levels of sIgE between them display a moderately correlation,indicating the existing of synergistic reaction.
