中华检验医学杂志
中華檢驗醫學雜誌
중화검험의학잡지
CHINESE JOURNAL OF LABORATORY MEDICINE
2014年
3期
166-169
,共4页
微粒%磷脂酰丝氨酸类%血栓形成%生物学标记
微粒%燐脂酰絲氨痠類%血栓形成%生物學標記
미립%린지선사안산류%혈전형성%생물학표기
Microparticles%Phosphatidylserines%Thrombosis%Biological markers
循环微粒来源于多种细胞,包括血小板、白细胞、内皮细胞和红细胞.另外,肿瘤细胞也能释放微粒到血液中.微粒的形成是膜磷脂重构和细胞骨架水解的后果.微粒表面的磷脂酰丝氨酸(PS)和组织因子(TF)促进Xase和凝血酶原酶的形成,激活凝血和诱发血栓形成.正常人血液中有一定数量的血小板来源的PS+微粒.血栓性疾病如脓毒症、癌症及心肌梗死时,血液PS+微粒和TF+微粒增多,单核细胞是TF+微粒的主要来源.因此,微粒可作为评估个体血栓风险的一个有效的生物标志物.
循環微粒來源于多種細胞,包括血小闆、白細胞、內皮細胞和紅細胞.另外,腫瘤細胞也能釋放微粒到血液中.微粒的形成是膜燐脂重構和細胞骨架水解的後果.微粒錶麵的燐脂酰絲氨痠(PS)和組織因子(TF)促進Xase和凝血酶原酶的形成,激活凝血和誘髮血栓形成.正常人血液中有一定數量的血小闆來源的PS+微粒.血栓性疾病如膿毒癥、癌癥及心肌梗死時,血液PS+微粒和TF+微粒增多,單覈細胞是TF+微粒的主要來源.因此,微粒可作為評估箇體血栓風險的一箇有效的生物標誌物.
순배미립래원우다충세포,포괄혈소판、백세포、내피세포화홍세포.령외,종류세포야능석방미립도혈액중.미립적형성시막린지중구화세포골가수해적후과.미립표면적린지선사안산(PS)화조직인자(TF)촉진Xase화응혈매원매적형성,격활응혈화유발혈전형성.정상인혈액중유일정수량적혈소판래원적PS+미립.혈전성질병여농독증、암증급심기경사시,혈액PS+미립화TF+미립증다,단핵세포시TF+미립적주요래원.인차,미립가작위평고개체혈전풍험적일개유효적생물표지물.
Circulating microparticles (MPs) derive from a variety of cells,including platelets,leukocytes,endothelial cells and erythrocytes.In addition,tumor cells release MPs into blood.MPs are formed as a result of membrane lipid remodeling and proteolytic cleavage of cytoskeleton.Exposure of phosphatidylserine (PS) and tissue factor (TF) provide a surface for the assembly of Xase and prothrombianse to activate coagulation and induce thrombosis.Considerable levels of platelet-derived PS+ MPs are detected in healthy subjects.However,the level of PS+ and TF+ MPs,the latter of which predominantly derived from monocytes,greatly increased in thrombotic diseases,such as sepsis,cancer,and myocardial infarction.Therefore,MPs could be a useful biomarker for the evaluation of thrombosis risk.
