CAJ | 학술논문

生长分化因子15(GDF-15)属于转化生长因子-β超家族成员,在某些病理条件下表达增加,是正调节因子.GDF-15可用于急性冠状动脉综合征、心力衰竭甚至肺栓塞等心血管疾病的诊断与筛查、预后预测并指导治疗,极具应用前景.但也存在一些问题亟需解决,包括如何快速检测以提高其临床实用性,在各种心血管病诊疗和危险分层的切点,如何进一步提高检测的敏感度和特异度,以及如何和其他特异度标志物联合应用等.
생장분화인자15(GDF-15)속우전화생장인자-β초가족성원,재모사병리조건하표체증가,시정조절인자.GDF-15가용우급성관상동맥종합정、심력쇠갈심지폐전새등심혈관질병적진단여사사、예후예측병지도치료,겁구응용전경.단야존재일사문제극수해결,포괄여하쾌속검측이제고기림상실용성,재각충심혈관병진료화위험분층적절점,여하진일보제고검측적민감도화특이도,이급여하화기타특이도표지물연합응용등.
As a new biomarker and a member of transforming growth factor super family,growth differentiation factor-15 (GDF-15) is increased in some pathological situations,and plays a positive role.Increasing evidence from animals and clinical trials has indicated that GDF-15 is a promising biomarker to be used for diagnosis,screening,risk stratification and prognosis evaluation in acute coronary syndrome,heart failure and pulmonary vascular diseases.However,there are still numerous challenges and problems need to be resolved in the future,such as appropriate cut-off value in diagnosis and risk stratification in different cardiovascular diseases,improvement in sensitivity and specificity,and combinational application with other biomarkers.