中华检验医学杂志
中華檢驗醫學雜誌
중화검험의학잡지
CHINESE JOURNAL OF LABORATORY MEDICINE
2014年
7期
513-516
,共4页
冠心病%新蝶呤%生物学标记
冠心病%新蝶呤%生物學標記
관심병%신접령%생물학표기
Coronary disease%Neopterin%Biological markers
目的 讨论新蝶呤(NP)、Gensini评分和超敏C反应蛋白(hs-CRP)之间的关系,探讨NP在冠心病患者中的重要作用.方法 入选2012年1至9月武汉大学人民医院心血管内科住院患者442例,其中对照组患者176例,试验组冠心病患者266例,利用Gensini评分评估冠心病患者冠状动脉病变严重程度,血清NP浓度由ELISA测定,其他指标由全自动生化分析仪和全自动凝血分析仪检测.数据分析采用SPSS19.0统计软件,对照组和试验组的比较采用样本t检验;3组之间的比较采用单因素方差分析;NP与Gensini评分和hs-CRP相关性分析采用Spearman相关性分析.结果 试验组患者血清NP浓度较对照组高,分别为(1.99±0.37)和(1.48±0.29) ng/ml,P＜0.05,并且NP浓度与冠心病严重程度呈正相关,与稳定性心绞痛(SA)组相比,不稳定型心绞痛(UA)组血清NP浓度(2.00 ±0.37) ng/ml,急性心肌梗死(AMI)组血清NP浓度(2.10±0.43) ng/ml明显升高(t=2.38,P＜0.05).同时,血清NP与Gensini评分呈正相关(r=0.687,P＜0.001),血清NP与hs-CRP呈正相关(r =0.190,P＜0.001).结论 炎症因子NP血清浓度在冠心病患者中显著升高,并且与冠心病严重程度呈正相关,NP有可能成为评估冠状动脉粥样硬化炎症反应的新指标.
目的 討論新蝶呤(NP)、Gensini評分和超敏C反應蛋白(hs-CRP)之間的關繫,探討NP在冠心病患者中的重要作用.方法 入選2012年1至9月武漢大學人民醫院心血管內科住院患者442例,其中對照組患者176例,試驗組冠心病患者266例,利用Gensini評分評估冠心病患者冠狀動脈病變嚴重程度,血清NP濃度由ELISA測定,其他指標由全自動生化分析儀和全自動凝血分析儀檢測.數據分析採用SPSS19.0統計軟件,對照組和試驗組的比較採用樣本t檢驗;3組之間的比較採用單因素方差分析;NP與Gensini評分和hs-CRP相關性分析採用Spearman相關性分析.結果 試驗組患者血清NP濃度較對照組高,分彆為(1.99±0.37)和(1.48±0.29) ng/ml,P＜0.05,併且NP濃度與冠心病嚴重程度呈正相關,與穩定性心絞痛(SA)組相比,不穩定型心絞痛(UA)組血清NP濃度(2.00 ±0.37) ng/ml,急性心肌梗死(AMI)組血清NP濃度(2.10±0.43) ng/ml明顯升高(t=2.38,P＜0.05).同時,血清NP與Gensini評分呈正相關(r=0.687,P＜0.001),血清NP與hs-CRP呈正相關(r =0.190,P＜0.001).結論 炎癥因子NP血清濃度在冠心病患者中顯著升高,併且與冠心病嚴重程度呈正相關,NP有可能成為評估冠狀動脈粥樣硬化炎癥反應的新指標.
목적 토론신접령(NP)、Gensini평분화초민C반응단백(hs-CRP)지간적관계,탐토NP재관심병환자중적중요작용.방법 입선2012년1지9월무한대학인민의원심혈관내과주원환자442례,기중대조조환자176례,시험조관심병환자266례,이용Gensini평분평고관심병환자관상동맥병변엄중정도,혈청NP농도유ELISA측정,기타지표유전자동생화분석의화전자동응혈분석의검측.수거분석채용SPSS19.0통계연건,대조조화시험조적비교채용양본t검험;3조지간적비교채용단인소방차분석;NP여Gensini평분화hs-CRP상관성분석채용Spearman상관성분석.결과 시험조환자혈청NP농도교대조조고,분별위(1.99±0.37)화(1.48±0.29) ng/ml,P＜0.05,병차NP농도여관심병엄중정도정정상관,여은정성심교통(SA)조상비,불은정형심교통(UA)조혈청NP농도(2.00 ±0.37) ng/ml,급성심기경사(AMI)조혈청NP농도(2.10±0.43) ng/ml명현승고(t=2.38,P＜0.05).동시,혈청NP여Gensini평분정정상관(r=0.687,P＜0.001),혈청NP여hs-CRP정정상관(r =0.190,P＜0.001).결론 염증인자NP혈청농도재관심병환자중현저승고,병차여관심병엄중정도정정상관,NP유가능성위평고관상동맥죽양경화염증반응적신지표.
Objective The study focused on the relationship between neopterin (NP),Gensini score and high-sensitivity C-reactive protein (hs-CRP) to explore the important role of the neopterin in patients with coronary heart disease.Methods Total of 442 patients,admitted to the Department of Cardiology at Renmin Hospital,Wuhan University from January 2012 to September 2012,were enrolled in this study.There were 176 patients in the control group and 266 patients with coroary disease in the experimental group.The Gensini score was used to assess the severity of the coronary lesions in the patients with coronary heart disease.The enzyme-linked immunosorbent assays (ELISAs) were used to measure the serum NP level.The other indicators were assessed by use of fully automatic biochemical and coagulation analyzers.The data were analyzed by using of SPSS19.0.T-test was used for analysis of the results between the control group and the experimental group.One-factor analysis variance (ANOVA) was used for comparisons of the results among the 3 groups,and Spearman correlation analysis was used for the correlation analysis between the NP level and Gensini score as well as hs-CRP level.Results The serum NP level was higher in the experimental group than that in the control group [(1.99 ± 0.37) vs (1.48 ± 0.29) ng/ml,P ＜0.05],and the NP level was positively correlated with the severity of coronary heart disease.Compared with the stable angina (SA) group,the serum NP level was significantly increased in the unstable angina (UA) group (2.00 ± 0.37) ng/ml and the acute myocardial infarction (AMI) group (2.10 ± 0.43) ng/ml (t =2.38,P ＜ 0.05).In addition,the serum NP level was positively correlated with the Gensini score (r =0.687,P＜0.001) as well as with the level of hs-CRP (r=0.190,P＜0.001).Conclusions The serum level of NP was significantly higher in patients with coronary heart disease and was positively correlated with the severity of coronary artery disease.Thus,NP may become a new indicator for the assessment of the inflammatory response in coronary atherosclerosis.
