CAJ | 학술논문

抗磷脂抗体(APLs)是辅助诊断抗磷脂综合征(APS)的重要实验室指标,是血栓形成和合并妊娠时的主要危险因素之一.但是由于APLs存在显著异质性,检测方法标准化程度较低,不同实验室间检测结果一致性较差,一定程度上限制了APLs检测的临床应用和对于APS诊治结果的进一步认识.因此,亟须建立APLs检测的标准化体系,提高检测方法的特异性、敏感性和重复性,实施设计合理的APLs检测结果大规模的临床评估.
항린지항체(APLs)시보조진단항린지종합정(APS)적중요실험실지표,시혈전형성화합병임신시적주요위험인소지일.단시유우APLs존재현저이질성,검측방법표준화정도교저,불동실험실간검측결과일치성교차,일정정도상한제료APLs검측적림상응용화대우APS진치결과적진일보인식.인차,극수건립APLs검측적표준화체계,제고검측방법적특이성、민감성화중복성,실시설계합리적APLs검측결과대규모적림상평고.
Antiphospholipid antibodies (APLs) are important for the diagnosis of antiphospholipid syndrome (APS),especially for predicting the risk of thrombosis and pathological pregnancy.However,the heterogeneity of antiphospholipid antibodies,lacking of standardization and significant interlaboratory variation binder the clinical application of APLs and better understanding of APS diagnosis and treatment.Therefore,it is urgent to establish a standardize system for antiphospholipid antibodies test and to improve the performance of the test and perform well-designed clinical evaluation.