中华检验医学杂志
中華檢驗醫學雜誌
중화검험의학잡지
CHINESE JOURNAL OF LABORATORY MEDICINE
2014年
8期
567-569
,共3页
自身免疫疾病%狼疮肾炎%抗肾小球基膜疾病%抗体,抗中性白细胞胞质
自身免疫疾病%狼瘡腎炎%抗腎小毬基膜疾病%抗體,抗中性白細胞胞質
자신면역질병%랑창신염%항신소구기막질병%항체,항중성백세포포질
Autoimmune diseases%Lupus nephritis%Anti-glomerular basement membrane disease%Antibodies,antineutrophil cytoplasmic
自身免疫性疾病突出表现为血清中多种自身抗体的形成及全身多脏器损伤,其中肾脏是最常见、最重要的受累器官之一.自身抗体在自身免疫性肾脏病的诊断、指导治疗及判断预后方面具有重要作用.最常见的自身免疫性肾脏病为狼疮性肾炎、抗中性粒细胞胞浆抗体(ANCA)相关小血管炎肾损害和抗肾小球基底膜(GBM)病.抗C1q抗体在狼疮性肾炎、ANCA在ANCA相关小血管炎和抗GBM抗体在抗GBM病中分别发挥着重要作用,合理、稳定的检测体系对临床医师至关重要,而临床医师也应正确对这些自身抗体的结果进行解读.
自身免疫性疾病突齣錶現為血清中多種自身抗體的形成及全身多髒器損傷,其中腎髒是最常見、最重要的受纍器官之一.自身抗體在自身免疫性腎髒病的診斷、指導治療及判斷預後方麵具有重要作用.最常見的自身免疫性腎髒病為狼瘡性腎炎、抗中性粒細胞胞漿抗體(ANCA)相關小血管炎腎損害和抗腎小毬基底膜(GBM)病.抗C1q抗體在狼瘡性腎炎、ANCA在ANCA相關小血管炎和抗GBM抗體在抗GBM病中分彆髮揮著重要作用,閤理、穩定的檢測體繫對臨床醫師至關重要,而臨床醫師也應正確對這些自身抗體的結果進行解讀.
자신면역성질병돌출표현위혈청중다충자신항체적형성급전신다장기손상,기중신장시최상견、최중요적수루기관지일.자신항체재자신면역성신장병적진단、지도치료급판단예후방면구유중요작용.최상견적자신면역성신장병위랑창성신염、항중성립세포포장항체(ANCA)상관소혈관염신손해화항신소구기저막(GBM)병.항C1q항체재랑창성신염、ANCA재ANCA상관소혈관염화항GBM항체재항GBM병중분별발휘착중요작용,합리、은정적검측체계대림상의사지관중요,이림상의사야응정학대저사자신항체적결과진행해독.
Autoimmune diseases are characterized by the presence of various autoantibodies and may cause injuries to multiple organs,with kidney as the most common and important organ involved.Autoantibodies are of great importance in the diagnosis,treatment and prognosis of autoimmune renal diseases.Lupus nephritis,anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitis and antiglomerular basement membrane (GBM) disease are the most common autoimmune renal diseases.Anti-C1q antibody,ANCA and anti-GBM antibody play important roles in those diseases,respectively.Appropriate and steady detecting methods are crucial to clinicians,and the results should also be interpreted with great cautions.
