CAJ | 학술논문

目的评价血清抗突变型瓜氨酸波形蛋白(MCV)抗体检测对类风湿关节炎(RA)的诊断价值.方法 Meta分析.检索1990年1月至2013年1月美国国立医学图书馆数据库网上检索系统(PubMed)、荷兰医学文摘数据库(Embase)和中国知网期刊数据库(CNKI)等数据库有关抗MCV抗体检测诊断RA的文献.采用Meta-Disc1.4对纳入研究进行综合定量评价,分析异质性来源及绘制综合受试者工作曲线(SROC).应用Stata11软件,采用Begg's检验识别发表偏倚.结果共纳入27篇研究,合并分析的敏感度、特异度分别是0.74(0.73 ～0.76)、0.83(0.82 ～0.85),SROC曲线下面积(AUC)是0.896.其中23篇同时检测抗MCV抗体和抗环瓜氨酸(CCP)抗体的研究进行合并AUC分析,抗MCV抗体、抗CCP抗体检测诊断类风湿关节炎的AUC分别为0.887和0.924,两者差异无统计学意义(Z=1.525,P=0.064).结论抗MCV抗体对于RA的诊断具有较高的敏感度与特异度,但与抗CCP抗体相比,对RA的诊断效能差异无统计学意义.
목적 평개혈청항돌변형과안산파형단백(MCV)항체검측대류풍습관절염(RA)적진단개치.방법 Meta분석.검색1990년1월지2013년1월미국국립의학도서관수거고망상검색계통(PubMed)、하란의학문적수거고(Embase)화중국지망기간수거고(CNKI)등수거고유관항MCV항체검측진단RA적문헌.채용Meta-Disc1.4대납입연구진행종합정량평개,분석이질성래원급회제종합수시자공작곡선(SROC).응용Stata11연건,채용Begg's검험식별발표편의.결과 공납입27편연구,합병분석적민감도、특이도분별시0.74(0.73 ～0.76)、0.83(0.82 ～0.85),SROC곡선하면적(AUC)시0.896.기중23편동시검측항MCV항체화항배과안산(CCP)항체적연구진행합병AUC분석,항MCV항체、항CCP항체검측진단류풍습관절염적AUC분별위0.887화0.924,량자차이무통계학의의(Z=1.525,P=0.064).결론 항MCV항체대우RA적진단구유교고적민감도여특이도,단여항CCP항체상비,대RA적진단효능차이무통계학의의.
Objective To assess the diagnostic value of anti-mutated citrullinated vimentin (MCV)antibody for rheumatoid arthritis (RA).Methods Meta analysis.The databases,including PubMed,The Excerpta Medica Database (Embase) and China National Knowledge Infrastructure (CNKI),from January 1990 to January 2013,were employed to search for the studies related to diagnostic value of anti-MCV for RA.The software Meta-Disc1.4 was used to perform Meta-analysis,investigate the sources of heterogeneity and draw the summary receiver operating characteristic (SROC) curve.The Begg's test was applied to evaluate the publication bias by use of Stata1 1 software.Results A total of 27 studies were included.Pooled sensitivity was 0.74[95％ confidence interval (CI) 0.73 to 0.76] and pooled specificity was 0.83 [95％ CI (0.82 to 0.85)].The area under the summary receiver operating characteristic curves was 0.896.Twenty-three literatures which detected both anti-MCV antibody and anti-cyclic citrullinated peptide(antikCCP) antibody show that:the area under curre of anti-MCV antibody and anti-CCP antibody were 0.887 and 0.924 respectively,but there was no significant difference (Z =1.525,P =0.064).Conclusions Results of the meta-analysis demonstrated that the MCV antibody may be a useful parameter in diagnosing RA as it shows high sensitivity and specificity.But there was no statistical difference between the results of anti-MCV antibody and anti-CCP antibody for the RA diagnosis.