CAJ | 학술논문

目的分析芬太尼联合咪唑安定的机理,通过与一些常用麻醉方法的对比,判断其在麻醉中伦理性的优势体现.方法将45只大鼠随机分为三组,A组:1％戊巴比妥钠40 mg/kg腹腔注射麻醉;B组:5％氯胺酮120mg/kg腹腔注射;C组:咪达唑仑5 mg/kg+芬太尼0.05 mg/kg尾静脉注射麻醉.观察麻醉效果.结果使用芬太尼联合咪唑安定的麻醉方式,麻醉起效时间为:0.02±0.03 min,麻醉维持时间为:89.73±22.59 min,麻醉操作时间为:1.51±0.30 min,麻醉成功例数为:15例.结论芬太尼联合咪唑安定的方法与目前常用的麻醉方法相比,优点较为突出,尤其对实验大鼠麻醉中的安全性、利用率以及复苏后的动物伦理问题都有显著的提高和保障.
목적 분석분태니연합미서안정적궤리,통과여일사상용마취방법적대비,판단기재마취중윤리성적우세체현.방법 장45지대서수궤분위삼조,A조:1％무파비타납40 mg/kg복강주사마취;B조:5％록알동120mg/kg복강주사;C조:미체서륜5 mg/kg+분태니0.05 mg/kg미정맥주사마취.관찰마취효과.결과 사용분태니연합미서안정적마취방식,마취기효시간위:0.02±0.03 min,마취유지시간위:89.73±22.59 min,마취조작시간위:1.51±0.30 min,마취성공례수위:15례.결론 분태니연합미서안정적방법여목전상용적마취방법상비,우점교위돌출,우기대실험대서마취중적안전성、이용솔이급복소후적동물윤리문제도유현저적제고화보장.
Objective To analyze the mechanism of fentanyl combines midazolam,by comparison with some of the commonly used anesthetic method to determine in the ethical advantages of anesthesia.Methods 45 rats were randomly divided into three groups,Group A:1％ anesthetized by intraperitoneal injection of sodium pentobarbital 40 mg/kg; Group B:5 ％ ketamine 120 mg/kg intraperitoneal injection; Group C:midazolam 5 mg/kg + fentanyl 0.05 mg/kg Last intravenous anesthesia.Observe the effects of anesthesia.Results The rats which are used of fentanyl conbines midazolam anesthesia,the onset of anesthesia time:0.02 ± 0.03 min,maintenance of anesthesia time:89.73 ± 22.59 min,the the narcotic operation time:1.51 ± 0.30 min,the success of anesthesia cases:15 cases.Conclusions Fentanyl combines midazolam compared with the currently used method of anesthesia,the advantages of the more prominent,it has significant improvement and protection about the security,utilization and recovery ethics in experimental rats.