中华医学美学美容杂志
中華醫學美學美容雜誌
중화의학미학미용잡지
CHINESE JOURNAL OF MEDICAL AESTHETICS AND COSMETOLOGY
2013年
4期
291-294
,共4页
黄进军%柳大烈%耿健%王晋煌
黃進軍%柳大烈%耿健%王晉煌
황진군%류대렬%경건%왕진황
下颌骨%神经切除术%A型肉毒毒素%骨密度
下頜骨%神經切除術%A型肉毒毒素%骨密度
하합골%신경절제술%A형육독독소%골밀도
Mandible%Neurectomy%Botulinum toxin type A%Bone mineral density(BMD)
目的 探讨咬肌神经切除和化学去神经对大鼠下颌骨骨密度的影响.方法 以28 d龄Wistar大鼠为实验模型.实验分为4组:手术1组:切除右侧咬肌神经；手术2组:显露但不切除右侧咬肌神经；肉毒毒素组:右侧咬肌肌内注射A型肉毒毒素；对照组:仅麻醉.75 d时取各组双侧完整下颌骨,用双能X线骨密度仪测量感兴趣区的骨密度.结果 大鼠下颌骨骨密度(BMD):手术1组左侧为(0.184±0.012) g/cm2,右侧为(0.184±0.026)g/cm2；手术2组左侧为(0.179±0.022) g/cm2,右侧为(0.173±0.019) g/cm2;肉毒毒素组左侧为(0.165±0.061) g/cm2,右侧为(0.158±0.051) g/cm2;对照组左侧为(0.196±0.026) g/cm2,右侧为(0.185士0.022)g/cm2.组间左右侧差异均无统计学意义(P＞0.05)；右侧下颌骨BMD组间比较:手术1组、手术2组和对照组差异无统计学意义(P＞0.05),肉毒毒素组和对照组差异无统计学意义(P＞0.05).结论切除幼龄大鼠咬肌神经、咬肌肌内注射A型肉毒毒素,对成年后下颌骨骨密度无明显影响.
目的 探討咬肌神經切除和化學去神經對大鼠下頜骨骨密度的影響.方法 以28 d齡Wistar大鼠為實驗模型.實驗分為4組:手術1組:切除右側咬肌神經；手術2組:顯露但不切除右側咬肌神經；肉毒毒素組:右側咬肌肌內註射A型肉毒毒素；對照組:僅痳醉.75 d時取各組雙側完整下頜骨,用雙能X線骨密度儀測量感興趣區的骨密度.結果 大鼠下頜骨骨密度(BMD):手術1組左側為(0.184±0.012) g/cm2,右側為(0.184±0.026)g/cm2；手術2組左側為(0.179±0.022) g/cm2,右側為(0.173±0.019) g/cm2;肉毒毒素組左側為(0.165±0.061) g/cm2,右側為(0.158±0.051) g/cm2;對照組左側為(0.196±0.026) g/cm2,右側為(0.185士0.022)g/cm2.組間左右側差異均無統計學意義(P＞0.05)；右側下頜骨BMD組間比較:手術1組、手術2組和對照組差異無統計學意義(P＞0.05),肉毒毒素組和對照組差異無統計學意義(P＞0.05).結論切除幼齡大鼠咬肌神經、咬肌肌內註射A型肉毒毒素,對成年後下頜骨骨密度無明顯影響.
목적 탐토교기신경절제화화학거신경대대서하합골골밀도적영향.방법 이28 d령Wistar대서위실험모형.실험분위4조:수술1조:절제우측교기신경；수술2조:현로단불절제우측교기신경；육독독소조:우측교기기내주사A형육독독소；대조조:부마취.75 d시취각조쌍측완정하합골,용쌍능X선골밀도의측량감흥취구적골밀도.결과 대서하합골골밀도(BMD):수술1조좌측위(0.184±0.012) g/cm2,우측위(0.184±0.026)g/cm2；수술2조좌측위(0.179±0.022) g/cm2,우측위(0.173±0.019) g/cm2;육독독소조좌측위(0.165±0.061) g/cm2,우측위(0.158±0.051) g/cm2;대조조좌측위(0.196±0.026) g/cm2,우측위(0.185사0.022)g/cm2.조간좌우측차이균무통계학의의(P＞0.05)；우측하합골BMD조간비교:수술1조、수술2조화대조조차이무통계학의의(P＞0.05),육독독소조화대조조차이무통계학의의(P＞0.05).결론절제유령대서교기신경、교기기내주사A형육독독소,대성년후하합골골밀도무명현영향.
Objective To evaluate the effect of neurectomy and chemodenervation of the masseter muscle on mandible bone mineral density.Methods Thirty 28-day-old Wistar rats were divided into four groups:operation groups 1 and 2,botulinum toxin group and control group.The main trunk and initial branches of masseteric nerve on the right side were resected in the operation group 1.The nerve was exposed,but not resected in the operation group 2.The right side of masseter muscle was injected with botulinum toxin type A and the left side was injected with sterile saline in botulinum toxin group when the rats were 28 days old.The control group was only anaesthetised.Bilateral mandibles of all four groups were scanned by GE lunar prodigy bone densitometer when the rats were 75 days old.Results BMD was (0.184±0.012) g/cm2 on the left side and (0.184±0.026) g/cm2on the right side in operation group 1.BMD was (0.179±0.022) g/cm2 on the left side and (0.173±0.019) g/cm2 on the right side in operation group 2.BMD was (0.165±0.061) g/cm2 on the left side and (0.158±0.051) g/cm2 on the right side in botulinum toxin group.BMD was (0.196±0.026) g/cm2 on the left side and (0.185±0.022) g/cm2 on the right side in control group.The variance of BMD between two sides of each group was not significant difference.The variances of BMD among the right side of the four groups were not significant difference.Conclusions No pathological changes in mandibular bone mineral density after denervation and chemodenervation of the massetermuscle are observed in this study.
