CAJ | 학술논문

目的观察光动力疗法(photodynamic therapy,PDT)治疗不同类型酒渣鼻的疗效及其安全性,并与外用10％磺胺醋酰钠、5％硫磺复合霜剂的疗效对比,确定两种治疗方法的优劣.方法酒渣鼻患者43例,随机分为2组,其中23例为PDT组,20例为外用药组.PDT组每7～10 d行PDT治疗1次,共治疗3次;外用药组每日用药治疗2次,连续30 d.治疗前后拍照片存档,医师根据照片单盲评价症状改善程度,皮损减轻60％以上视为治疗有效;患者自我记录不良反应,并评价其严重程度;治疗前后要求患者填写皮肤病生活质量指标量表,评价生活质量改善程度.结果 PDT组治疗1个月后,总有效率为65％,其中丘疹脓疱型患者有效率为71％,红斑毛细血管扩张型患者有效率为50％;外用药组治疗总有效率为35％.PDT组和外用药组治疗总有效率差异有统计学意义(P＜0.05).PDT组患者生活质量改善程度优于外用药组;PDT治疗和外用药治疗均没有不可逆性不良反应产生.结论 PDT治疗酒渣鼻安全有效,可明显改善患者生活质量,出现的不良反应少且可逆.
목적 관찰광동력요법(photodynamic therapy,PDT)치료불동류형주사비적료효급기안전성,병여외용10％광알작선납、5％류광복합상제적료효대비,학정량충치료방법적우렬.방법 주사비환자43례,수궤분위2조,기중23례위PDT조,20례위외용약조.PDT조매7～10 d행PDT치료1차,공치료3차;외용약조매일용약치료2차,련속30 d.치료전후박조편존당,의사근거조편단맹평개증상개선정도,피손감경60％이상시위치료유효;환자자아기록불량반응,병평개기엄중정도;치료전후요구환자전사피부병생활질량지표량표,평개생활질량개선정도.결과 PDT조치료1개월후,총유효솔위65％,기중구진농포형환자유효솔위71％,홍반모세혈관확장형환자유효솔위50％;외용약조치료총유효솔위35％.PDT조화외용약조치료총유효솔차이유통계학의의(P＜0.05).PDT조환자생활질량개선정도우우외용약조;PDT치료화외용약치료균몰유불가역성불량반응산생.결론 PDT치료주사비안전유효,가명현개선환자생활질량,출현적불량반응소차가역.
Objective To investigate the efficacy and safety of photodynamic therapy (PDT) in the treatment of different types of rosacea,and to evaluate its benefit by comparing its efficacy with 10％ sodium sulfacetamide and 5％ sulfur emollient foam.Methods Forty-three subjects with rosacea were enrolled in this study.They were randomized to be treated with PDT (twenty-three subjects) or 10％ sodium sulfacetamide and 5％ sulfur emollient foam (twenty subjects).PDT group subjects received PDT once every seven to ten days for three times while the 10％ sodium sulfacetamide or 5％sulfur emollient foam was applied 2 times per day for thirty days in the other group.Digital photographs were taken before and after one month of treatment in both groups.Blinded independent physicians graded improvement based on these photographs utilizing a percentile evaluation scale.A more than sixty percent remission proved the treatment to be effective.All the complications occurred during the therapy were taken notes and their severity was classified by the subjects.Two dermatology life quality index forms were completed before and after treatment by the subjects to evaluate the change in terms of their quality of life.Results After one month of treatment,PDT proved to be effective on sixty-five percent of subjects (seventy-one percent on papulopustular rosacea and fifty percent on erythematotelangiectatic rosacea).The emollient foam proved to be effective on thirty-five percent of subjects.Statistically significant difference was observed between the overall effective rate of PDT and emollient foam (P＜0.05).In addition,a greater improvement in terms of the quality of life was experienced by the PDT group subjects.No irreversible adverse event was observed in both groups during the study.Conclusions PDT proves to be an effective and safe treatment for rosacea with satisfactory efficacy,significant improvement in patients' quality of life and few irreversible side effects.