中华医学美学美容杂志
中華醫學美學美容雜誌
중화의학미학미용잡지
CHINESE JOURNAL OF MEDICAL AESTHETICS AND COSMETOLOGY
2014年
1期
55-57
,共3页
瘢痕疙瘩%淋巴管%肿瘤浸润
瘢痕疙瘩%淋巴管%腫瘤浸潤
반흔흘탑%림파관%종류침윤
Keloid%Lymphatic vesseis%Neoplasm invasiveness
目的 探讨瘢痕疙瘩微淋巴管密度与其呈侵袭性生长的相关性.方法 手术切取瘢痕疙瘩10例,根据瘢痕疙瘩的特点将每例瘢痕疙瘩分为浸润部位、增生部位及边缘正常皮肤,非瘢痕疙瘩者的瘢痕疙瘩好发区域的正常皮肤作为对照,应用免疫组织化学染色,对瘢痕疙瘩增生部位、浸润部位、边缘正常皮肤及非瘢痕疙瘩者的正常皮肤微淋巴管密度进行检测分析.结果 瘢痕疙瘩边缘正常皮肤微淋巴管密度(12.563±1.803)条/mm2,与非瘢痕疙瘩的正常皮肤微淋巴管密度(11.071±2.645)条/mm2差异无统计学意义(t=1.389,P＞0.05);瘢痕疙瘩浸润部位微淋巴管密度(27.315±7.430)条/mm2,明显高于增生部(17.375±6.221)条/mm2及边缘正常皮肤(12.563±1.803)条/mm2,差异有统计学意义(x2=16.8,P＜0.05);瘢痕疙瘩增生部与边缘正常皮肤微淋巴管密度的表达差异有统计学意义(t=2.276,P＜0.05).结论 瘢痕疙瘩浸润部的微淋巴管密度增高可能与瘢痕疙瘩呈侵袭性生长有一定关系.
目的 探討瘢痕疙瘩微淋巴管密度與其呈侵襲性生長的相關性.方法 手術切取瘢痕疙瘩10例,根據瘢痕疙瘩的特點將每例瘢痕疙瘩分為浸潤部位、增生部位及邊緣正常皮膚,非瘢痕疙瘩者的瘢痕疙瘩好髮區域的正常皮膚作為對照,應用免疫組織化學染色,對瘢痕疙瘩增生部位、浸潤部位、邊緣正常皮膚及非瘢痕疙瘩者的正常皮膚微淋巴管密度進行檢測分析.結果 瘢痕疙瘩邊緣正常皮膚微淋巴管密度(12.563±1.803)條/mm2,與非瘢痕疙瘩的正常皮膚微淋巴管密度(11.071±2.645)條/mm2差異無統計學意義(t=1.389,P＞0.05);瘢痕疙瘩浸潤部位微淋巴管密度(27.315±7.430)條/mm2,明顯高于增生部(17.375±6.221)條/mm2及邊緣正常皮膚(12.563±1.803)條/mm2,差異有統計學意義(x2=16.8,P＜0.05);瘢痕疙瘩增生部與邊緣正常皮膚微淋巴管密度的錶達差異有統計學意義(t=2.276,P＜0.05).結論 瘢痕疙瘩浸潤部的微淋巴管密度增高可能與瘢痕疙瘩呈侵襲性生長有一定關繫.
목적 탐토반흔흘탑미림파관밀도여기정침습성생장적상관성.방법 수술절취반흔흘탑10례,근거반흔흘탑적특점장매례반흔흘탑분위침윤부위、증생부위급변연정상피부,비반흔흘탑자적반흔흘탑호발구역적정상피부작위대조,응용면역조직화학염색,대반흔흘탑증생부위、침윤부위、변연정상피부급비반흔흘탑자적정상피부미림파관밀도진행검측분석.결과 반흔흘탑변연정상피부미림파관밀도(12.563±1.803)조/mm2,여비반흔흘탑적정상피부미림파관밀도(11.071±2.645)조/mm2차이무통계학의의(t=1.389,P＞0.05);반흔흘탑침윤부위미림파관밀도(27.315±7.430)조/mm2,명현고우증생부(17.375±6.221)조/mm2급변연정상피부(12.563±1.803)조/mm2,차이유통계학의의(x2=16.8,P＜0.05);반흔흘탑증생부여변연정상피부미림파관밀도적표체차이유통계학의의(t=2.276,P＜0.05).결론 반흔흘탑침윤부적미림파관밀도증고가능여반흔흘탑정침습성생장유일정관계.
Objective To study the lymphatic microvessel density of keloid and correlation of invasive growth.Methods Invasive part,proliferative part and peripheral normal skin of keloid patients (n=10) were collected by surgical excision,and normal skin of keloid and non-keloid patients as control.Lymphatic vessel density of different parts of keloid and normal skin were investigated by immunohistochemical staining using the lymphatic endothelium specific marker D2-40.Results There were no significant differences between lymphatic microvessel density of peripheral normal skin of keloid (12.563 ±1.803) n/mm2 and normal skin of non-keloid patients (11.071 ± 2.645) n/mm2 (t=1.389,P＞0.05); Lymphatic microvessel density of invasive part of keloid (27.315 ± 7.430) n/mm2 was significantly higher than those of proliferative part of keloid (17.375± 6.221) n/mm2 and normal skin (12.563±1.803) n/mm2 (x2 =16.8,P＜0.01); there were significant differences between proliferative parts of keloid and normal skin (t=2.276,P＜0.05).Conclusions Lymphatic microvessel density increase in the invasive part of keloid may have a certain relationship with invasive growth.
