CAJ | 학술논문

目的观察血卟啉单甲醚声动力疗法对兔耳增生性瘢痕(hyperplastic scar,HS)的疗效.方法成年大耳白兔60只,随机分成5组.在声动力治疗第2、4、6、8周分别切取两组瘢痕组织,进行指标检测.结果治疗组可降低成纤维细胞密度、瘢痕增生指数,与模型对照组比较差异有统计学意义(P＜0.05),可降低胶原纤维的面密度,从上皮化后第4周开始与模型组比较差异有统计学意义(P＜0.01).结论声动力效应能够显著降低兔耳HS,可望为HS治疗提供新的手段.
목적 관찰혈계람단갑미성동력요법대토이증생성반흔(hyperplastic scar,HS)적료효.방법 성년대이백토60지,수궤분성5조.재성동력치료제2、4、6、8주분별절취량조반흔조직,진행지표검측.결과 치료조가강저성섬유세포밀도、반흔증생지수,여모형대조조비교차이유통계학의의(P＜0.05),가강저효원섬유적면밀도,종상피화후제4주개시여모형조비교차이유통계학의의(P＜0.01).결론 성동력효응능구현저강저토이HS,가망위HS치료제공신적수단.
Objective To observe the clinical efficacy of HMME-SDT therapy for the treatment of hypertrophic scar (HS) of rabbit ear.Methods 60 white rabbits were randomly divided into five groups.The model group and HMME-SDT treatment group were used to establish the models of hypertrophic scar in ears.Results The effect of HMME-SDT on the fibroblastic density in the hypertrophic scarring models was observed in rabbit ears.The HMME-SDT could lower the fibroblastic density,compared with the model group,with significant difference (P＜ 0.05).The effect of HMME-SDT on the collagen area density was noted in the hypertrophic scarring models in rabbit ears.The HMME-SDT could lower the collagen area density,compared with the model group,with significant difference from the fourth week of the epithelialization (P＜0.01).Conclusions HMME is an effective sonosensitizer.HMME-SDT can significantly inhibit hypertrophic scar of rabbit ear.