中华医学遗传学杂志
中華醫學遺傳學雜誌
중화의학유전학잡지
CHINESE JOURNAL OF MEDICAL GENETICS
2012年
5期
592-595
,共4页
张利芸%汪亚芸%何琴%陈曼华
張利蕓%汪亞蕓%何琴%陳曼華
장리예%왕아예%하금%진만화
单核苷酸多态性%2型糖尿病%急性冠脉综合征
單覈苷痠多態性%2型糖尿病%急性冠脈綜閤徵
단핵감산다태성%2형당뇨병%급성관맥종합정
Single nucleotide polymorphism%Diabetes mellitus%Acute coronary syndrome
目的 调查rs501120位点不同基因型糖尿病合并初发急性冠脉综合征患者急性冠脉综合征的再发生状况,以了解rs501120位点基因多态性与冠状动脉病变进展程度及斑块不稳定的关系.方法 选取2型糖尿病合并初发急性冠脉综合征患者902例,采用TaqMan-MGB探针检测rs50112位点的单核苷酸多态性(single nucleotide polymorphism,SNP),从中选取年龄与性别相匹配的TT型、TC型与CC型病例各205例,随访观察3年,调查不同基因型人群急性冠脉综合征再发生状况.结果 TT基因型人群急性冠脉综合征再发生率较CC型显著升高(TT vs CC,OR=1.7,95％CI:1.1～2.7,P=0.02),TT基因型人群心肌梗死发生率较CC型升高,差异有统计学意义(TT vs CC,OR=1.9,95％CI:1.2～3.2,P=0.007).经Logistic回归分析去除混杂因素后,TT基因型人群对比CC基因型人群仍有显著升高的急性冠脉综合征再发风险(OR=1.6,95％CI:1.05～3.6,P=O.03).结论 rs501120位点基因多态性可能与冠状动脉病变进展程度及斑块不稳定相关.
目的 調查rs501120位點不同基因型糖尿病閤併初髮急性冠脈綜閤徵患者急性冠脈綜閤徵的再髮生狀況,以瞭解rs501120位點基因多態性與冠狀動脈病變進展程度及斑塊不穩定的關繫.方法 選取2型糖尿病閤併初髮急性冠脈綜閤徵患者902例,採用TaqMan-MGB探針檢測rs50112位點的單覈苷痠多態性(single nucleotide polymorphism,SNP),從中選取年齡與性彆相匹配的TT型、TC型與CC型病例各205例,隨訪觀察3年,調查不同基因型人群急性冠脈綜閤徵再髮生狀況.結果 TT基因型人群急性冠脈綜閤徵再髮生率較CC型顯著升高(TT vs CC,OR=1.7,95％CI:1.1～2.7,P=0.02),TT基因型人群心肌梗死髮生率較CC型升高,差異有統計學意義(TT vs CC,OR=1.9,95％CI:1.2～3.2,P=0.007).經Logistic迴歸分析去除混雜因素後,TT基因型人群對比CC基因型人群仍有顯著升高的急性冠脈綜閤徵再髮風險(OR=1.6,95％CI:1.05～3.6,P=O.03).結論 rs501120位點基因多態性可能與冠狀動脈病變進展程度及斑塊不穩定相關.
목적 조사rs501120위점불동기인형당뇨병합병초발급성관맥종합정환자급성관맥종합정적재발생상황,이료해rs501120위점기인다태성여관상동맥병변진전정도급반괴불은정적관계.방법 선취2형당뇨병합병초발급성관맥종합정환자902례,채용TaqMan-MGB탐침검측rs50112위점적단핵감산다태성(single nucleotide polymorphism,SNP),종중선취년령여성별상필배적TT형、TC형여CC형병례각205례,수방관찰3년,조사불동기인형인군급성관맥종합정재발생상황.결과 TT기인형인군급성관맥종합정재발생솔교CC형현저승고(TT vs CC,OR=1.7,95％CI:1.1～2.7,P=0.02),TT기인형인군심기경사발생솔교CC형승고,차이유통계학의의(TT vs CC,OR=1.9,95％CI:1.2～3.2,P=0.007).경Logistic회귀분석거제혼잡인소후,TT기인형인군대비CC기인형인군잉유현저승고적급성관맥종합정재발풍험(OR=1.6,95％CI:1.05～3.6,P=O.03).결론 rs501120위점기인다태성가능여관상동맥병변진전정도급반괴불은정상관.
Objective To assess the association between single nucleotide polymorphism rs501120 and progress of unstable coronary atherosclerotic plaque in diabetes mellitus complicated with acute coronary syndrome (ACS).Methods Nine hundred and two patients with diabetes complicated with acute coronary syndrome were enrolled.The genotype of rs501120 was determined with TaqMan-MGB probes.Two hundred and five cases of TT genotype,205 age-and sex-frequency-matched cases of TC genotype and 205 age-and sex-frequency-matched cases of CC genotype were chosen and followed up for 3 years.Clinical data and re-occurrences of ACS were recorded.Results Patients with TT genotype had a significantly higher incidence of recurrence of ACS than those with CC genotype (TT vs.CC:OR 1.7,95％CI 1.1-2.7,P=0.02).And the significance has remained even after adjusting for conventional risk factors by logistic regression (OR 1.6,95 ％CI 1.05-3.6,P =0.03).Patients with TT genotype had a significantly higher incidence of myocardial infarction than those with CC genotype(TT vs.CC:OR 1.9,95％CI 1.2-3.2,P=0.007).Conclusion Our results has suggested an association between the rs501120 polymorphism and progress of unstable coronary atherosclerotic plaque.
