中华医学遗传学杂志
中華醫學遺傳學雜誌
중화의학유전학잡지
CHINESE JOURNAL OF MEDICAL GENETICS
2013年
1期
70-73
,共4页
肺癌%慢性阻塞性肺病%表观遗传学%DNA甲基化%组蛋白修饰%非编码RNA
肺癌%慢性阻塞性肺病%錶觀遺傳學%DNA甲基化%組蛋白脩飾%非編碼RNA
폐암%만성조새성폐병%표관유전학%DNA갑기화%조단백수식%비편마RNA
Lung cancer%Chronic obstructive pulmonary disease%Epigenetics%DNA methylation%Histone modification%Non-coding RNA
肺癌是严重影响人类健康的恶性肿瘤之一,影响肺癌发病的表观遗传学机制已成为近年来的研究热点.慢性阻塞性肺病(chronic obstructive pulmonary disease,COPD)不但是肺癌的常见合并症,而且可能是肺癌的独立风险因素.肺癌和COPD在表观遗传学水平的改变主要涉及DNA甲基化、组蛋白修饰和非编码RNA调控等.探讨肺癌与COPD在表观遗传学水平的改变及其相互关系,可为肺癌及COPD的发病机制、疾病进展、疾病预后等提供更为广阔的视角,并为疾病的治疗开辟新的方向.
肺癌是嚴重影響人類健康的噁性腫瘤之一,影響肺癌髮病的錶觀遺傳學機製已成為近年來的研究熱點.慢性阻塞性肺病(chronic obstructive pulmonary disease,COPD)不但是肺癌的常見閤併癥,而且可能是肺癌的獨立風險因素.肺癌和COPD在錶觀遺傳學水平的改變主要涉及DNA甲基化、組蛋白脩飾和非編碼RNA調控等.探討肺癌與COPD在錶觀遺傳學水平的改變及其相互關繫,可為肺癌及COPD的髮病機製、疾病進展、疾病預後等提供更為廣闊的視角,併為疾病的治療開闢新的方嚮.
폐암시엄중영향인류건강적악성종류지일,영향폐암발병적표관유전학궤제이성위근년래적연구열점.만성조새성폐병(chronic obstructive pulmonary disease,COPD)불단시폐암적상견합병증,이차가능시폐암적독립풍험인소.폐암화COPD재표관유전학수평적개변주요섭급DNA갑기화、조단백수식화비편마RNA조공등.탐토폐암여COPD재표관유전학수평적개변급기상호관계,가위폐암급COPD적발병궤제、질병진전、질병예후등제공경위엄활적시각,병위질병적치료개벽신적방향.
Lung cancer and chronic obstructive pulmonary disease (COPD) are the leading causes of morbidity and mortality worldwide.Development of lung cancer involves both genetic and environment factors.In addition to genetic alterations,epigenetic mechanism is closely involved in pathogenesis of lung cancer.Characterized by an abnormal persistent inflammatory response to noxious environmental stimulation,COPD has shown to increase the susceptibility for lung tumorigenesis in previous research.Current research on epigenetics of lung cancer and COPD has focused on aberrant DNA methylation,histone acetylation and non-coding RNAs regulation.The aberrant DNA methylation associated with lung cancer and COPD has included overexpression of DNA methyltransferase,global DNA hypomethylation and DNA hypermethylation in promoter regions,while histone acetylation and histone methylation are the major changes for histone modification,in which histone acetyltransferases,histone deacetylases,histone methyltransferases and histone demethylases play the most important roles.RNA interference and microRNAs are both hot topics of research on non-coding RNAs regulation.Understanding of concurrent epigenetic alterations in the pathogenesis of lung cancer and COPD may facilitate identification of specific therapeutic targets and development of effective treatment.
