中华医学遗传学杂志
中華醫學遺傳學雜誌
중화의학유전학잡지
CHINESE JOURNAL OF MEDICAL GENETICS
2013年
3期
365-369
,共5页
张钏%郭孟境%裴利国%朱浩%贾飞%屈蕾%党洁%陆宏%霍正浩
張釧%郭孟境%裴利國%硃浩%賈飛%屈蕾%黨潔%陸宏%霍正浩
장천%곽맹경%배리국%주호%가비%굴뢰%당길%륙굉%곽정호
雄激素受体基因%短串联重复序列%多态性%回族%汉族
雄激素受體基因%短串聯重複序列%多態性%迴族%漢族
웅격소수체기인%단천련중복서렬%다태성%회족%한족
AR gene%Short tandem repeats%Polymorphisms%Hui ethnics%Han ethnics
目的 研究雄激素受体(androgen receptor,AR)基因(CAG)n、(GGN)n重复序列多态性在宁夏回、汉族群体中的分布特征.方法 用ABI 3730XL测序仪测定AR基因的(CAG)n及(GGN)n重复数目并对结果进行分析.结果 CAG等位基因在宁夏回、汉族群体中的分布差异无统计学意义(P＞0.05).GGN等位基因在两个群体中的分布差异有统计学意义(P＜0.01),汉族女性GGN重复数为23的等位基因频率(48.4％)显著低于回族女性(64.7％,P=0.01).结论 AR基因GGN等位基因在宁夏回、汉族群体中的分布差异有统计学意义(P＜0.01).
目的 研究雄激素受體(androgen receptor,AR)基因(CAG)n、(GGN)n重複序列多態性在寧夏迴、漢族群體中的分佈特徵.方法 用ABI 3730XL測序儀測定AR基因的(CAG)n及(GGN)n重複數目併對結果進行分析.結果 CAG等位基因在寧夏迴、漢族群體中的分佈差異無統計學意義(P＞0.05).GGN等位基因在兩箇群體中的分佈差異有統計學意義(P＜0.01),漢族女性GGN重複數為23的等位基因頻率(48.4％)顯著低于迴族女性(64.7％,P=0.01).結論 AR基因GGN等位基因在寧夏迴、漢族群體中的分佈差異有統計學意義(P＜0.01).
목적 연구웅격소수체(androgen receptor,AR)기인(CAG)n、(GGN)n중복서렬다태성재저하회、한족군체중적분포특정.방법 용ABI 3730XL측서의측정AR기인적(CAG)n급(GGN)n중복수목병대결과진행분석.결과 CAG등위기인재저하회、한족군체중적분포차이무통계학의의(P＞0.05).GGN등위기인재량개군체중적분포차이유통계학의의(P＜0.01),한족녀성GGN중복수위23적등위기인빈솔(48.4％)현저저우회족녀성(64.7％,P=0.01).결론 AR기인GGN등위기인재저하회、한족군체중적분포차이유통계학의의(P＜0.01).
Objective To compare the distribution of (CAG)n and (GGN)n repeats polymorphisms of androgen receptor (AR) gene between Hui and Han ethnic Chinese from Ningxia.Methods Genotypes of above repeats were determined with DNA sequencing method.Results The distribution of (GGN)n repeats was significantly different between the two ethnic groups (P＜0.01),though no such difference was detected with (CAG)n repeats (P＞0.05).Particularly,Han Chinese women carrying 23 GGN repeats were significantly fewer (48.4％) than H ui women (64.7 ％,P =0.01).Conclusion The distribution of GGN repeat is significantly differently among Hui and Han Chinese ethnics from Ningxia.
