CAJ | 학술논문

目的探讨单体核型急性髓细胞白血病(monosomal karyotype acute myeloid leukemia,MK-AML)患者的临床和细胞遗传学特征.方法对3743例初发AML患者的染色体核型进行分析,将发现的153例MK-AML患者的年龄、性别、FAB分型、外周血象、白血病免疫分型和核型进行归纳分析.结果 3743例确诊的初发AML患者中存在染色体核型异常的病例总计2056例,其中153例为MK-AML,占该组AML的4.1％(153/3743).男性病例多见(93例),中位年龄54岁.中位白细胞计数为4.4×109/L.其中同时符合复杂染色体核型诊断标准的病例为145例,占94.8％(145/153).1～22号染色单体都被检测到,所有单体中-7最多,共59例,占38.56％(59/153).结论 MK-AML是AML患者中一类独特的细胞遗传学亚型,以7号染色体单体最为多见,在中老年AML患者中多见.
목적 탐토단체핵형급성수세포백혈병(monosomal karyotype acute myeloid leukemia,MK-AML)환자적림상화세포유전학특정.방법 대3743례초발AML환자적염색체핵형진행분석,장발현적153례MK-AML환자적년령、성별、FAB분형、외주혈상、백혈병면역분형화핵형진행귀납분석.결과 3743례학진적초발AML환자중존재염색체핵형이상적병례총계2056례,기중153례위MK-AML,점해조AML적4.1％(153/3743).남성병례다견(93례),중위년령54세.중위백세포계수위4.4×109/L.기중동시부합복잡염색체핵형진단표준적병례위145례,점94.8％(145/153).1～22호염색단체도피검측도,소유단체중-7최다,공59례,점38.56％(59/153).결론 MK-AML시AML환자중일류독특적세포유전학아형,이7호염색체단체최위다견,재중노년AML환자중다견.
Objective To investigate the clinical and genetics characteristics of patients with monosomal karyotype acute myeloid leukemia (MK-AML).Methods The karyotypes of 3743 patients with newly-diagnosed de novo AML were analyzed,which had identified 153 cases with MK-AML,for whom the clinical and genetics characteristics were analyzed.Results There were 2056 patients (54.9％) among all patients.A total of 153 patients fulfilling the criteria for MK-AML were identified,which comprised 93 males and 60 females,with a median age of 54.The median white blood cell count on presentation was 4.4 × 109/L.One hundred and forty-five cases (94.8％) have fulfilled the criteria for complex karyotype (≥ 3 chromosomal abnormalities).Although the monosomy could be found with all autosomes,chromosome 7 has been most frequently involved (38.56％,59/153).Conclusion MK-AML is a distinct cytogenetic subtype of AML.Monosomy 7 is frequently detected among MK-AML patients.The monosomal karyotype is common among elder patients with AML.