中华肿瘤杂志
中華腫瘤雜誌
중화종류잡지
CHINESE JOURNAL OF ONCOLOGY
2011年
12期
921-924
,共4页
李建周%金勇君%刘欣%张凌云
李建週%金勇君%劉訢%張凌雲
리건주%금용군%류흔%장릉운
甲状腺肿瘤%促甲状腺素%甲状腺结节
甲狀腺腫瘤%促甲狀腺素%甲狀腺結節
갑상선종류%촉갑상선소%갑상선결절
Thyroid neoplasms%Thyrotropin%Thyroid nodule
目的 观察血清促甲状腺素(TSH)水平与甲状腺癌发病的关系.方法 回顾性分析330例(恶性99例,良性231例)行甲状腺手术的甲状腺疾病患者的血清TSH水平、性别、年龄、肿瘤类型、结节个数,并探讨其与甲状腺癌发生之间的关系.结果 在年龄＜20岁和≥70岁的患者中,甲状腺癌所占的比例分别为63.0％和58.3％,明显高于60 ～ 69岁组(23.3％,均P＜0.05).在81例男性患者中,甲状腺癌所占的比例为43.2％,明显高于女性患者(25.7％,P=0.003).在112例单结节患者中,甲状腺癌所占的比例为42.0％,明显高于多结节患者(23.9％,P＜0.001).在TSH＜ 0.28mIU/L组和≥4.20 mIU/L组患者中,甲状腺癌所占的比例分别为54.6％和50.0％,均明显高于0.28～1.44 mIU/L组(16.1％,均P＜0.05)；在正常TSH范围内,甲状腺癌所占与的比例随TSH水平的升高而升高(P ＜0.001).血清TSH水平高(OR=1.465,P=0.014)、男性(OR=1.964,P=0.016)以及单个甲状腺结节( OR=2.090,P=0.006)均为发生甲状腺癌的独立危险因素.结论 血清TSH水平高、男性、单个甲状腺结节者患甲状腺癌的风险高.
目的 觀察血清促甲狀腺素(TSH)水平與甲狀腺癌髮病的關繫.方法 迴顧性分析330例(噁性99例,良性231例)行甲狀腺手術的甲狀腺疾病患者的血清TSH水平、性彆、年齡、腫瘤類型、結節箇數,併探討其與甲狀腺癌髮生之間的關繫.結果 在年齡＜20歲和≥70歲的患者中,甲狀腺癌所佔的比例分彆為63.0％和58.3％,明顯高于60 ～ 69歲組(23.3％,均P＜0.05).在81例男性患者中,甲狀腺癌所佔的比例為43.2％,明顯高于女性患者(25.7％,P=0.003).在112例單結節患者中,甲狀腺癌所佔的比例為42.0％,明顯高于多結節患者(23.9％,P＜0.001).在TSH＜ 0.28mIU/L組和≥4.20 mIU/L組患者中,甲狀腺癌所佔的比例分彆為54.6％和50.0％,均明顯高于0.28～1.44 mIU/L組(16.1％,均P＜0.05)；在正常TSH範圍內,甲狀腺癌所佔與的比例隨TSH水平的升高而升高(P ＜0.001).血清TSH水平高(OR=1.465,P=0.014)、男性(OR=1.964,P=0.016)以及單箇甲狀腺結節( OR=2.090,P=0.006)均為髮生甲狀腺癌的獨立危險因素.結論 血清TSH水平高、男性、單箇甲狀腺結節者患甲狀腺癌的風險高.
목적 관찰혈청촉갑상선소(TSH)수평여갑상선암발병적관계.방법 회고성분석330례(악성99례,량성231례)행갑상선수술적갑상선질병환자적혈청TSH수평、성별、년령、종류류형、결절개수,병탐토기여갑상선암발생지간적관계.결과 재년령＜20세화≥70세적환자중,갑상선암소점적비례분별위63.0％화58.3％,명현고우60 ～ 69세조(23.3％,균P＜0.05).재81례남성환자중,갑상선암소점적비례위43.2％,명현고우녀성환자(25.7％,P=0.003).재112례단결절환자중,갑상선암소점적비례위42.0％,명현고우다결절환자(23.9％,P＜0.001).재TSH＜ 0.28mIU/L조화≥4.20 mIU/L조환자중,갑상선암소점적비례분별위54.6％화50.0％,균명현고우0.28～1.44 mIU/L조(16.1％,균P＜0.05)；재정상TSH범위내,갑상선암소점여적비례수TSH수평적승고이승고(P ＜0.001).혈청TSH수평고(OR=1.465,P=0.014)、남성(OR=1.964,P=0.016)이급단개갑상선결절( OR=2.090,P=0.006)균위발생갑상선암적독립위험인소.결론 혈청TSH수평고、남성、단개갑상선결절자환갑상선암적풍험고.
Objective To investigate the association between serum TSH concentration and thyroid cancer incidence.Methods Three hundred and thirty patients with thyroid tumors who underwent surgical treatment were included in this study (99 cases of malignancy and 231 cases of benign tumors ).The data of their serum TSH level,gender,age,tumor type,and number of tumors detected by ultrasonic inspection were retrospectively analyzed,and their association with thyroid cancer incidence was explored.Results The proportion of thyroid cancer in the groups of younger than twenty years and older than seventy years were 63.0％ and 58.3％,respectively,significantly higher than that in the group of age between 60 and 69 years (23.3％,P＜0.05).The incidence of thyroid cancer of the 81 male patients was 43.2％,significantly higher than that in the 249 female patients ( 25.7％,P =0.003 ).The incidence of thyroid cancer in the 112 patients with single nodule was 42.0％,significantly higher than that in the 218 patients with multiple nodules (23.9％,P ＜0.001 ).In the groups with TSH level lower than 0.28 mIU/L and higher than 4.20mIU/L,the incidence of thyroid cancer were 54.6％ and 50.0％,respectively,significantly higher than that in the group with TSH level between 0.28 and 1.44 mIU/L ( 16.1％,P ＜ 0.05 ).The proportion of patients with thyroid cancer was also increased with the increasing serum TSH level in the normal range (P ＜0.001 ).High serum TSH level ( OR =1.465,P =0.014),male ( OR =1.964,P =0.016) and a single thyroid nodule ( OR =2.090,P =0.006) are independent risk factors of thyroid cancer.Conclusion The high serum TSH level,male,single thyroid nodule are factors leading to a high incidence of thyroid cancer.
