CAJ | 학술논문

目的探讨Rab5a和APPL1在乳腺癌组织中的表达及意义.方法采用免疫组织化学方法检测40例乳腺纤维瘤组织和74例乳腺癌组织中Rab5a和APPL1的表达水平,分析其与乳腺癌转移、病理分级和人表皮生长因子受体2 (HER-2)表达的相关性.结果 Rab5a和APPL1在乳腺纤维瘤组织中的阳性率分别为45.0％和30.0％,在乳腺癌组织中的阳性率分别为91.9％和83.8％(均P＜0.01).Rab5a在乳腺癌HER-2阳性组和阴性组中的阳性率分别为92.6％和90.0％ (P ＜0.05),APPL1在乳腺癌HER-2阳性组和阴性组中的阳性率分别为85.2％和80.0％ (P ＞0.05).Rab5a和APPL1在有无乳腺癌局部转移和不同病理学分级中的表达差异无统计学意义(P＞0.05).结论 Rab5a和APPL1在乳腺癌中高表达,并与HER-2表达呈正相关；Rab5a和APPL1可能通过调节HER-2的信号传导而影响乳腺癌细胞生物学行为.
목적 탐토Rab5a화APPL1재유선암조직중적표체급의의.방법 채용면역조직화학방법검측40례유선섬유류조직화74례유선암조직중Rab5a화APPL1적표체수평,분석기여유선암전이、병리분급화인표피생장인자수체2 (HER-2)표체적상관성.결과 Rab5a화APPL1재유선섬유류조직중적양성솔분별위45.0％화30.0％,재유선암조직중적양성솔분별위91.9％화83.8％(균P＜0.01).Rab5a재유선암HER-2양성조화음성조중적양성솔분별위92.6％화90.0％ (P ＜0.05),APPL1재유선암HER-2양성조화음성조중적양성솔분별위85.2％화80.0％ (P ＞0.05).Rab5a화APPL1재유무유선암국부전이화불동병이학분급중적표체차이무통계학의의(P＞0.05).결론 Rab5a화APPL1재유선암중고표체,병여HER-2표체정정상관；Rab5a화APPL1가능통과조절HER-2적신호전도이영향유선암세포생물학행위.
Objective To investigate the expression of Rab5a and APPL1 in breast cancer and fibroma,and analyze their correlation with HER-2 expression,metastasis and development of breast cancer.Methods Rab5a and APPL1 in paraffin embedded tissues of 74 breast carcinomas and 40 breast fibromas were detected by immunohistochemistry.Their relationship with metastasis,pathological grade,and HER-2 expression in breast cancer was determined by statistical analysis.Results There was no expression or low expression of Rab5a and APPL1 in the breast fibroma,but the positive expression rate of Rab5a and APPL1 in the breast carcinomas were 91.9％ and 83.8％,respectively.No significant difference in expression of Rab5a and APPL1 was found between metastatic and non-metastatic groups,and pathological grade Ⅰ/Ⅱ and grade Ⅲ groups.But Rab5a was overexpressed in HER-2-positive group compared with that in the HER-2-negative group.Conclusions Rab5a and APPL1 are overexpressed in breast cancer,and are positively correlated with the HER-2 expression.These proteins may influence the growth and proliferation of breast cancer cells by HER-2 signal transduction.