CAJ | 학술논문

目的探讨肢体隔离热灌注化疗术在肢体恶性黑色素瘤中的治疗效果.方法对41例肢体恶性黑色素瘤患者行肢体隔离热灌注化疗术,术后14 ～ 21 d对有原发病灶的24例患者行原发病灶切除术,术后病理学检查评价肿瘤坏死情况.结果 41例患者中,随访40例,失访1例,随访时间为6～113个月,无一例患者出现局部复发.全组患者的3年和5年生存率分别为95.0％和70.0％.灌注后,肿瘤平均缩小55.6％,术后病理学检查肿瘤坏死率为90％～ 100％者21例(87.5％),60％～89％者3例(12.5％).结论肢体隔离热灌注化疗术是治疗肢体恶性黑色素瘤的有效方法,能显著降低局部复发率,提高长期生存率,改善患者的预后.
목적 탐토지체격리열관주화료술재지체악성흑색소류중적치료효과.방법 대41례지체악성흑색소류환자행지체격리열관주화료술,술후14 ～ 21 d대유원발병조적24례환자행원발병조절제술,술후병이학검사평개종류배사정황.결과 41례환자중,수방40례,실방1례,수방시간위6～113개월,무일례환자출현국부복발.전조환자적3년화5년생존솔분별위95.0％화70.0％.관주후,종류평균축소55.6％,술후병이학검사종류배사솔위90％～ 100％자21례(87.5％),60％～89％자3례(12.5％).결론 지체격리열관주화료술시치료지체악성흑색소류적유효방법,능현저강저국부복발솔,제고장기생존솔,개선환자적예후.
Objective To investigate the effect of isolated limb hyperthermic perfusion chemotherapy for melanoma of the extremities.Methods Limb isolated hyperthermic perfusion chemotherapy was performed in 41 patients with malignant melanoma of the extremities,and then the primary lesions in 24 patients were removed at 14-21 days after chemotherapy.Tumor necrosis was examined by pathology.Results Among the 41 patients,40 cases were followed up for 6-113 months,and one was lost.There was no local recurrence in those patients.29 cases were followed up for more than 3 years,and 26 of them were surviving.Forteen cases were followed up for more than five years,among them 9 cases were surviving.The 3-year and 5-year survival rates of the whole group were 95.0％ and 70.0％,respectively.The average reduction of the tumor volume was 55.6％ after perfusion.The pathological examination showed that tumor necrosis was 90％-100％ (complete response) in 21 cases (87.5％) and 60％-89％ (partial response) in 3 cases (12.5％).Conclusions The isolated limb hyperthermic perfusion chemotherapy is an effective treatment of limb malignant melanoma.It can significantly reduce the local recurrence rate,and improve the 5-year survival rate,prognosis and the quality of life of the patients.