CAJ | 학술논문

目的探讨低频旋转磁场治疗晚期恶性肿瘤的临床疗效和安全性.方法对137例晚期恶性肿瘤患者采用转速为400 r/min、磁场强度为0.4T的低频旋转磁场治疗.治疗范围包括原发病灶、转移器官和受累淋巴结.每d治疗1次,每次治疗2h,治疗30～50 d,平均42 d.结果 137例晚期恶性肿瘤患者全部完成低频旋转磁场治疗,其中显效者28例,有效者54例,临床治疗获益率为59.9％.患者治疗前的KPS评分、QOL评分以及肿瘤类型与治疗后的临床获益率有关(均P＜0.05).全组患者的中位生存时间为12个月,1、2、3年生存率分别为47.0％、11.8％和3.4％.单因素分析的结果显示,患者治疗前的KPS和QOL评分以及肿瘤类型与其接受低频旋转磁场治疗后的预后有关(均P＜0.05).多因素分析的结果显示,患者治疗前的QOL评分是影响其接受低频旋转磁场治疗预后的独立因素(P=0.037).治疗过程中,有11例患者出现乏力、病灶部位有轻微撕扯样或针刺样疼痛,6例患者略有心率增快或轻度体温升高,未予以处理,其症状均自行消失,无治疗相关性死亡发生.结论低频旋转磁场治疗晚期恶性肿瘤的临床有效率较高,安全性较好,可显著改善患者的预后.
목적 탐토저빈선전자장치료만기악성종류적림상료효화안전성.방법 대137례만기악성종류환자채용전속위400 r/min、자장강도위0.4T적저빈선전자장치료.치료범위포괄원발병조、전이기관화수루림파결.매d치료1차,매차치료2h,치료30～50 d,평균42 d.결과 137례만기악성종류환자전부완성저빈선전자장치료,기중현효자28례,유효자54례,림상치료획익솔위59.9％.환자치료전적KPS평분、QOL평분이급종류류형여치료후적림상획익솔유관(균P＜0.05).전조환자적중위생존시간위12개월,1、2、3년생존솔분별위47.0％、11.8％화3.4％.단인소분석적결과현시,환자치료전적KPS화QOL평분이급종류류형여기접수저빈선전자장치료후적예후유관(균P＜0.05).다인소분석적결과현시,환자치료전적QOL평분시영향기접수저빈선전자장치료예후적독립인소(P=0.037).치료과정중,유11례환자출현핍력、병조부위유경미시차양혹침자양동통,6례환자략유심솔증쾌혹경도체온승고,미여이처리,기증상균자행소실,무치료상관성사망발생.결론 저빈선전자장치료만기악성종류적림상유효솔교고,안전성교호,가현저개선환자적예후.
Objective To investigate the clinical efficacy and safety of low-frequency rotary magnetic fields in the treatment of patients with advanced malignant tumors.Methods 137 patients with advanced malignant tumors were exposed to 400 r/min,0.4 T low-frequency rotary magnetic fields.An area including the primary tumor,local metastasis and metastatic lymph nodes was exposed daily,2 hours per day for 30 ～ 50 days (average time of 42 days).Results All of the 137 patients completed the low-frequency rotary magnetic field treatment.There were 28 cases with complete response,54 cases with partial response,and the clinical benefit rate was 59.9％.The tumor type,initial KPS and QOL showed statistical significance in the clinical benefit rate (P ＜ 0.05).The median overall survival was 12 months,and the 1-year,2-year and 3-year survival rates were 47.0％,11.8％,3.4％,respectively.The tumor type,initial KPS and QOL were identified by univariate log-rank test as significant prognostic factors for overall survival (P ＜ 0.05).Multivariate analysis showed that the initial QOL was an independent prognostic factors (P =0.037).During the treatment,asthenia and local pain were observed in 11 patients,and 6 patients had mild tachycardia (increased 3 to 5/min) and/or temperature elevation (0.5 to 1.0℃).All above symptoms disappeared spontaneously.No treatment-related death was observed.Conclusions Low-frequency rotary magnetic fields is an effective and safe method in the treatment of patients with advanced malignant tumors,and may prolong survival significantly.