中华肿瘤杂志
中華腫瘤雜誌
중화종류잡지
CHINESE JOURNAL OF ONCOLOGY
2013年
11期
843-847
,共5页
刘尚国%李汉臣%赵宝生%曹峰
劉尚國%李漢臣%趙寶生%曹峰
류상국%리한신%조보생%조봉
食管肿瘤%激活素A%组织%血清%诊断%预后
食管腫瘤%激活素A%組織%血清%診斷%預後
식관종류%격활소A%조직%혈청%진단%예후
Esophageal neoplasms%Activin A%Tissue%Serum%Diagnosis%Prognosis
目的 探讨激活素A (activin A)在食管鳞癌患者肿瘤组织和血清中的表达及其临床意义.方法 采用免疫组织化学法检测activin A在64例食管鳞癌组织中的表达,采用酶联免疫吸附试验检测activin A在食管鳞癌患者手术前后血清中的水平,分析activin A表达与食管鳞癌患者临床病理特征的关系及其对预后的影响.结果 activin A在食管鳞癌组织和正常食管黏膜上皮组织中的阳性表达率分别为82.8％ (53/64)和6.7％(2/30),差异有统计学意义(P＜0.001).activin A表达与食管鳞癌的淋巴结转移和肿瘤浸润深度有关(均P＜0.05),activin A表达与淋巴结转移(r=0.321)和肿瘤浸润深度呈正相关(r=0.417,均P＜0.05).食管鳞癌患者手术前后的血清activin A水平分别为(911±276) pg/ml和(667±236) pg/ml,差异有统计学意义(P =0.005).单因素和多因素分析均显示,activin A表达和淋巴结转移为影响食管鳞癌患者预后的独立因素(均P＜0.05).结论 activin A可能在食管鳞癌的发生、发展中起重要作用,对食管癌的诊断和预后判断有重要参考价值.
目的 探討激活素A (activin A)在食管鱗癌患者腫瘤組織和血清中的錶達及其臨床意義.方法 採用免疫組織化學法檢測activin A在64例食管鱗癌組織中的錶達,採用酶聯免疫吸附試驗檢測activin A在食管鱗癌患者手術前後血清中的水平,分析activin A錶達與食管鱗癌患者臨床病理特徵的關繫及其對預後的影響.結果 activin A在食管鱗癌組織和正常食管黏膜上皮組織中的暘性錶達率分彆為82.8％ (53/64)和6.7％(2/30),差異有統計學意義(P＜0.001).activin A錶達與食管鱗癌的淋巴結轉移和腫瘤浸潤深度有關(均P＜0.05),activin A錶達與淋巴結轉移(r=0.321)和腫瘤浸潤深度呈正相關(r=0.417,均P＜0.05).食管鱗癌患者手術前後的血清activin A水平分彆為(911±276) pg/ml和(667±236) pg/ml,差異有統計學意義(P =0.005).單因素和多因素分析均顯示,activin A錶達和淋巴結轉移為影響食管鱗癌患者預後的獨立因素(均P＜0.05).結論 activin A可能在食管鱗癌的髮生、髮展中起重要作用,對食管癌的診斷和預後判斷有重要參攷價值.
목적 탐토격활소A (activin A)재식관린암환자종류조직화혈청중적표체급기림상의의.방법 채용면역조직화학법검측activin A재64례식관린암조직중적표체,채용매련면역흡부시험검측activin A재식관린암환자수술전후혈청중적수평,분석activin A표체여식관린암환자림상병리특정적관계급기대예후적영향.결과 activin A재식관린암조직화정상식관점막상피조직중적양성표체솔분별위82.8％ (53/64)화6.7％(2/30),차이유통계학의의(P＜0.001).activin A표체여식관린암적림파결전이화종류침윤심도유관(균P＜0.05),activin A표체여림파결전이(r=0.321)화종류침윤심도정정상관(r=0.417,균P＜0.05).식관린암환자수술전후적혈청activin A수평분별위(911±276) pg/ml화(667±236) pg/ml,차이유통계학의의(P =0.005).단인소화다인소분석균현시,activin A표체화림파결전이위영향식관린암환자예후적독립인소(균P＜0.05).결론 activin A가능재식관린암적발생、발전중기중요작용,대식관암적진단화예후판단유중요삼고개치.
Objective The aim of this study was to explore the expression of activin A in esophageal squamous cell carcinoma and its clinical significance.Methods Immunohistochemical (IHC)staining was used for detecting the expression of tissue activin A in sixty-four patients with esophageal squamous cell carcinoma,and enzyme-linked immunosorbent assay (ELISA) was used for detecting the serum activin A in the patients before and after surgery.The relationship between expression of activin A in the esophageal cancer tissue with clinicopathological features and its influence on prognosis were analyzed.Results The positive expression rate of activin A in esophageal squamous cell carcinoma was 82.8％ (53/64),and that of normal esophageal epithelium was 6.7％ (2/30),showing a very significant difference between them (P ＜ 0.001).Expression of activin A was correlated with both lymph node metastasis and invasion depth of the tumor (all P ＜ 0.05),and the expression of activin A was positively correlated with lymph node metastasis (r =0.321,P ＜ 0.05) and invasion depth of the tumor (r =0.417,P ＜ 0.05).The serum activin A of the patients before and after surgery was (911 ± 276) pg/ml and (667 ± 236) pg/ml,respectively,showing a significant difference (P =0.005).Univariate and multivariate analyses indicated that expression of activin A and lymph node metastasis were independent influencing factors for prognosis in patients with esophageal squamous cell carcinoma (all P ＜ 0.05).Conclusions Activin A may play an important role in the pathogenesis and development of esophageal squamous cell carcinoma,and it has an important reference value in the estimation of diagnosis and prognosis for esophageal squamous cell carcinoma.
