CAJ | 학술논문

目的评估非动物源性稳定性透明质酸凝胶(Restylane,瑞典Q-Med公司生产)注射治疗鼻唇沟皱纹的有效性和安全性.方法鼻唇沟部皱纹严重程度分级在中度以上的患者接受非动物源性稳定性透明质酸凝胶的注射治疗(每侧<1.5 ml).随访时间6个月.分别由医生和患者本人根据皱纹严重程度分级标准进行评分.研究者记录不良事件.治疗前后进行常规实验室检查.结果共86例患者接受鼻唇沟注射治疗(95%女性,平均年龄43岁).注射治疗6个月后,研究者和受试者分别评估,局部左右两侧鼻唇沟皱纹的评分均较注射前下降;面部整体美容效果的改善程度,均超过90%认为至少有某种程度的改善.在治疗6个月时,左右两侧鼻唇沟的应答率分别是81.4%和84.9%.治疗后6个月,32例(占受试者总数的37.2%)报告不良事件总数为52项,大多数被判断为注射部位反应.大多数不良反应为中度以下,并且可以自愈.没有全身反应.结论非动物源性稳定性透明质酸凝胶纠正中国人的鼻唇沟皱纹疗效好,并且安全可靠.
목적 평고비동물원성은정성투명질산응효(Restylane,서전Q-Med공사생산)주사치료비진구추문적유효성화안전성.방법 비진구부추문엄중정도분급재중도이상적환자접수비동물원성은정성투명질산응효적주사치료(매측<1.5 ml).수방시간6개월.분별유의생화환자본인근거추문엄중정도분급표준진행평분.연구자기록불량사건.치료전후진행상규실험실검사.결과 공86례환자접수비진구주사치료(95%녀성,평균년령43세).주사치료6개월후,연구자화수시자분별평고,국부좌우량측비진구추문적평분균교주사전하강;면부정체미용효과적개선정도,균초과90%인위지소유모충정도적개선.재치료6개월시,좌우량측비진구적응답솔분별시81.4%화84.9%.치료후6개월,32례(점수시자총수적37.2%)보고불량사건총수위52항,대다수피판단위주사부위반응.대다수불량반응위중도이하,병차가이자유.몰유전신반응.결론 비동물원성은정성투명질산응효규정중국인적비진구추문료효호,병차안전가고.
Objective To assess the safety and efficacy of hyaluronic acid-based gel of non-animal origin (NASHA~(TM) gel [Restylane~(R)]; Q-Med AB, Uppsala, Sweden)for correcting nasolabial folds in Chinese.Methods Patients with moderate or severe nasolabial fold(Wrinkle Severity Rating Scale, WSRS)were recruited to receive NASHA gel injection (< 1.5 ml). The patients were followed up for 6 months. The efficacy was assessed by physicians and patients, respectively. Adverse events(AEs)were recorded and laboratory tests were performed before and after operation. Results 86 patients were treated. 6 months after injection, improved esthetic results was assessed by patients and physicians independently. 52 AEs happened in 32 cases(37.2%).Most of them were local injection reaction and minor, which were recovered spontaneously. No systemic reaction was found. Conclusions NASHA gel can improve the nasolabial folds. It is very safe and tolerated.