CAJ | 학술논문

目的探讨β受体在婴幼儿血管瘤组织中的表达及意义.方法采用免疫组织化学SP法,检测40例婴幼儿血管瘤(实验组)、20例静脉畸形及10例正常皮肤(阴性对照组)标本组织中β受体的表达.结果 40例婴幼儿血管瘤中仅在28例标本中见β2受体呈阳性表达,阳性表达率70％(28/40),β1受体未见表达;28例阳性标本中24例为增殖期,4例为非增殖期,婴幼儿血管瘤与静脉畸形、正常皮肤组织β2受体阳性表达比较,差异有统计学意义,β2受体在增殖期与消退期的阳性表达比较,差异有统计学意义(P＜0.05).20例静脉畸形及10例正常皮肤组织中未见β1受体表达.结论 β2受体特异表达于婴幼儿血管瘤,且高表达于增殖期.
목적 탐토β수체재영유인혈관류조직중적표체급의의.방법 채용면역조직화학SP법,검측40례영유인혈관류(실험조)、20례정맥기형급10례정상피부(음성대조조)표본조직중β수체적표체.결과 40례영유인혈관류중부재28례표본중견β2수체정양성표체,양성표체솔70％(28/40),β1수체미견표체;28례양성표본중24례위증식기,4례위비증식기,영유인혈관류여정맥기형、정상피부조직β2수체양성표체비교,차이유통계학의의,β2수체재증식기여소퇴기적양성표체비교,차이유통계학의의(P＜0.05).20례정맥기형급10례정상피부조직중미견β1수체표체.결론 β2수체특이표체우영유인혈관류,차고표체우증식기.
Objective To investigate the expression and significance of beta-receptor(β-R) in infantile hemangioma.Methods The expression of β-R was detected by immunohistochemistry in infantile hemangioma(40 cases),venous malformation (20 cases) and normal skin (10 cases).Results The positive expression rate of β2-R was 70％ (28/40) in infantile hemangioma,while no expression of β2-R in venous malformation and normal skin.Among 28 cases with positive expression of β2-R,24 cases were in proliferative phase.The positive expression of β2-R in infantile hamangioma was significantly higher than that in venous malformation and normal skin tissue.The positive expression of β2-R in the proliferative hemangioma and non-proliferative hemangioma was also significantly different(P ＜ 0.05).Conclusions β2-R is specifically expressed in infantile hemangioma,especially in proliferative hemangioma.