肿瘤研究与临床
腫瘤研究與臨床
종류연구여림상
CANCER RESEARCH AND CLINIC
2010年
6期
400-403
,共4页
甲状腺肿瘤%环氧合酶-2%上皮钙黏素%血管内皮生长因子%免疫组织化学
甲狀腺腫瘤%環氧閤酶-2%上皮鈣黏素%血管內皮生長因子%免疫組織化學
갑상선종류%배양합매-2%상피개점소%혈관내피생장인자%면역조직화학
Thyroid neoplasms%Cyclookygenase-2%E-cadherin%Vascular endothelial growth factors%Immunohistochemistry
目的 探讨环氧合酶-2(COX-2)、血管内皮生长因子(VEGF)、上皮钙黏素(E-cadherin)在甲状腺癌中的表达及其临床病理意义.方法 采用免疫织织化学SP法检测68例甲状腺癌、16例甲状腺瘤及16例正常甲状腺组织中COX-2、E-cadherin、VEGF的表达,并对甲状腺癌组织学分型、临床病理分期及淋巴结转移进行对比分析.结果 68例甲状腺癌中COX-2、VEGF、E-cadherin的阳性表达率分别为63.2%、66.2%和60.3%,和甲状腺瘤相比较差异有统计学意义(P<0.05).甲状腺癌中COX-2、VEGF、E-cadherin的表达在不同临床病理分期、淋巴结转移状态差异均有统计学意义(P<0.05).E-cadherin与VEGF、COX-2的表达均呈负相关(r=-0.423,P<0.01;r=-0.413,P<0.01);COX-2与VEGF的表达呈正相关(r=0.659,P<0.01).结论 COX-2、E-cadherin、VEGF在甲状腺癌的发生、发展中起着重要作用,三者联合检测可为甲状腺癌恶性程度和预后的判断提供有效证据.
目的 探討環氧閤酶-2(COX-2)、血管內皮生長因子(VEGF)、上皮鈣黏素(E-cadherin)在甲狀腺癌中的錶達及其臨床病理意義.方法 採用免疫織織化學SP法檢測68例甲狀腺癌、16例甲狀腺瘤及16例正常甲狀腺組織中COX-2、E-cadherin、VEGF的錶達,併對甲狀腺癌組織學分型、臨床病理分期及淋巴結轉移進行對比分析.結果 68例甲狀腺癌中COX-2、VEGF、E-cadherin的暘性錶達率分彆為63.2%、66.2%和60.3%,和甲狀腺瘤相比較差異有統計學意義(P<0.05).甲狀腺癌中COX-2、VEGF、E-cadherin的錶達在不同臨床病理分期、淋巴結轉移狀態差異均有統計學意義(P<0.05).E-cadherin與VEGF、COX-2的錶達均呈負相關(r=-0.423,P<0.01;r=-0.413,P<0.01);COX-2與VEGF的錶達呈正相關(r=0.659,P<0.01).結論 COX-2、E-cadherin、VEGF在甲狀腺癌的髮生、髮展中起著重要作用,三者聯閤檢測可為甲狀腺癌噁性程度和預後的判斷提供有效證據.
목적 탐토배양합매-2(COX-2)、혈관내피생장인자(VEGF)、상피개점소(E-cadherin)재갑상선암중적표체급기림상병리의의.방법 채용면역직직화학SP법검측68례갑상선암、16례갑상선류급16례정상갑상선조직중COX-2、E-cadherin、VEGF적표체,병대갑상선암조직학분형、림상병리분기급림파결전이진행대비분석.결과 68례갑상선암중COX-2、VEGF、E-cadherin적양성표체솔분별위63.2%、66.2%화60.3%,화갑상선류상비교차이유통계학의의(P<0.05).갑상선암중COX-2、VEGF、E-cadherin적표체재불동림상병리분기、림파결전이상태차이균유통계학의의(P<0.05).E-cadherin여VEGF、COX-2적표체균정부상관(r=-0.423,P<0.01;r=-0.413,P<0.01);COX-2여VEGF적표체정정상관(r=0.659,P<0.01).결론 COX-2、E-cadherin、VEGF재갑상선암적발생、발전중기착중요작용,삼자연합검측가위갑상선암악성정도화예후적판단제공유효증거.
Objective To study the expression of COX-2,E-cadherin and VEGF in thyroid carcinoma and its clinicopathological significance.Methods Expression of COX-2,E-cadherin and VEGF was detected in 68 cases with thyroid carcinoma,16 cases with thyroid adenomas and 16 cases of normal thyroid tissue by SP immunohistochemical method.Results The expression of COX-2,E-cadherin and VEGF in 68 cases with thyroid carcinoma was 63.2%,61.8%and 66.2%,respectively,with significant difference(P<0.05)compared with the expression of these proteins in thyroid adenomas.Expression of COX-2,VEGF and E-cadherin Was significantly different with TNM stages and with lymph node metastasis status(P<0.05).Expression of E-cadherin was negatively correlated to the expression of VEGF and COX-2(r=-0.423,P<0.01;r=-0.413.P<0.01).Expression of COX-2 was positively related to the expression of VEGF(r=0.659,P<0.01). Conclusion COX-2, E-cadherin and VEGF play important roles in carcinogenesis and development of thyroid carcinoma. Combined detection can provide valuable evidence for estimation of aggressive degree and prognosis of thyroid carcinoma.
