肿瘤研究与临床
腫瘤研究與臨床
종류연구여림상
CANCER RESEARCH AND CLINIC
2010年
6期
404-405,409
,共3页
张莉%吴素慧%尚海霞%唐世倩%林维凤
張莉%吳素慧%尚海霞%唐世倩%林維鳳
장리%오소혜%상해하%당세천%림유봉
子宫颈肿瘤%白细胞介素-8%多态性,单核苷酸
子宮頸腫瘤%白細胞介素-8%多態性,單覈苷痠
자궁경종류%백세포개소-8%다태성,단핵감산
Cervical neoplasms%Interleukin-8%Polymorphism,single nucleotide
目的 探讨白细胞介素(IL)-8-251A/T单核苷酸多态性与子宫颈癌发病的相关性.方法 应用四引物扩增受阻突变体系-聚合酶链反应技术(Tetra-primer ARMS-PCR)分析217例子宫颈癌患者和190例健康对照者外周血IL-8-251A/T位点的基因多态性,用Logistic回归模型计算各种基因型的子宫颈癌风险(OR)及其95%可信区间.结果 IL-8-251A/T单核苷酸多态性三种基因型在病例组分别为18.89%、53.46%、27.65%,对照组则分别为35.79%、44.21%、20.00%,两组差异有统计学意义(P<0.05);TT基因型及T等位基因的子宫颈癌发病OR分别为2.619、1.639.结论 IL-8.251A/T基因多态性可能是子宫颈癌发病的遗传易感因素.
目的 探討白細胞介素(IL)-8-251A/T單覈苷痠多態性與子宮頸癌髮病的相關性.方法 應用四引物擴增受阻突變體繫-聚閤酶鏈反應技術(Tetra-primer ARMS-PCR)分析217例子宮頸癌患者和190例健康對照者外週血IL-8-251A/T位點的基因多態性,用Logistic迴歸模型計算各種基因型的子宮頸癌風險(OR)及其95%可信區間.結果 IL-8-251A/T單覈苷痠多態性三種基因型在病例組分彆為18.89%、53.46%、27.65%,對照組則分彆為35.79%、44.21%、20.00%,兩組差異有統計學意義(P<0.05);TT基因型及T等位基因的子宮頸癌髮病OR分彆為2.619、1.639.結論 IL-8.251A/T基因多態性可能是子宮頸癌髮病的遺傳易感因素.
목적 탐토백세포개소(IL)-8-251A/T단핵감산다태성여자궁경암발병적상관성.방법 응용사인물확증수조돌변체계-취합매련반응기술(Tetra-primer ARMS-PCR)분석217례자궁경암환자화190례건강대조자외주혈IL-8-251A/T위점적기인다태성,용Logistic회귀모형계산각충기인형적자궁경암풍험(OR)급기95%가신구간.결과 IL-8-251A/T단핵감산다태성삼충기인형재병례조분별위18.89%、53.46%、27.65%,대조조칙분별위35.79%、44.21%、20.00%,량조차이유통계학의의(P<0.05);TT기인형급T등위기인적자궁경암발병OR분별위2.619、1.639.결론 IL-8.251A/T기인다태성가능시자궁경암발병적유전역감인소.
Objective To investigate the relationship between single nucleotide polymorphisms of IL-8-251 A/T and the occurrence of cervical cancer.Methods A retrospective case-control study design Was applied for the present study.The cage group included peripheral blood samples from 217 cervical cancer patients and peripheral blood samples from 190 healthy women.Tetra-primer amplification refractory mutation system polymerase chain reaction Was used to analyze the genotype distribution and allele frequency of IL-8-251 A/T.Results It-8-251 MT gene polymowhisms included three genotypes:AA,AT and TT.Proportions of genotypes were 18.89%,53.46%,27.65%in cage group,respectively and were 35.79%,44.21%,20.00%in control group,respectively.There was statistical significance(P<0.05)between the case group and the control group.The risk of genotype TT and T allele for cervical cancer Wag 2.619 and 1.639.respectively.Conclusion IL-8-25 1 A/T may be a genetic susceptibility factors for cervical cancer.
