肿瘤研究与临床
腫瘤研究與臨床
종류연구여림상
CANCER RESEARCH AND CLINIC
2012年
11期
752-754
,共3页
牛剑峰%来守翠%刘少华%薛晶文%万向娜
牛劍峰%來守翠%劉少華%薛晶文%萬嚮娜
우검봉%래수취%류소화%설정문%만향나
子宫内膜肿瘤%组织激肽释放酶类%受体,雌激素%受体,孕激素
子宮內膜腫瘤%組織激肽釋放酶類%受體,雌激素%受體,孕激素
자궁내막종류%조직격태석방매류%수체,자격소%수체,잉격소
Endometrial neoplasms% Tissue kallikreins% Receptors,estrogen% Receptors,progesterone
目的 检测人类组织激肽释放酶10(KLK10)在不同子宫内膜组织中的表达,并探讨其与雌激素受体(ER)和孕激素受体(PR)之间的相关性.方法 应用免疫组织化学方法测定KLK10在12例正常子宫内膜、19例子宫内膜增生症、34例子宫内膜腺癌组织中的表达,并分析KLK10与ER、PR之间的相关性.结果 KLK10在正常子宫内膜组织、子宫内膜增生症组织、子宫内膜腺癌组织中阳性率分别为91.7％(11/12)、78.9％(15/19)、38.2％(13/34),两两比较差异均有统计学意义(均P＜0.05).KLK10在Ⅰ、Ⅱ、Ⅲ期子宫内膜腺癌组织中表达阳性率分别为64.3％(9/14)、30.0％(3/10)、10.0％(1/10),两两比较差异均有统计学意义(均P＜0.05).KLK10在高、中、低分化的内膜腺癌组织中表达阳性率分别为66.7％(8/12)、33.3％(4/ 12)、10.0％(1/10),两两比较差异均有统计学意义(均P＜ 0.05).34例子宫内膜腺癌组织中,KLK10表达阳性率为38.2％,ER、PR表达阳性率为67.6％、55.9％,KLK10与ER、PR表达均呈正相关(x2=0.448,P＜0.01).结论 KLK1O表达缺失或下调可能促进子宫内膜腺癌的发生和发展.KLK10在子宫内膜腺癌组织中表达降低,ER、PR的表达也降低,呈正相关.KLK10阳性者预后相对较好.
目的 檢測人類組織激肽釋放酶10(KLK10)在不同子宮內膜組織中的錶達,併探討其與雌激素受體(ER)和孕激素受體(PR)之間的相關性.方法 應用免疫組織化學方法測定KLK10在12例正常子宮內膜、19例子宮內膜增生癥、34例子宮內膜腺癌組織中的錶達,併分析KLK10與ER、PR之間的相關性.結果 KLK10在正常子宮內膜組織、子宮內膜增生癥組織、子宮內膜腺癌組織中暘性率分彆為91.7％(11/12)、78.9％(15/19)、38.2％(13/34),兩兩比較差異均有統計學意義(均P＜0.05).KLK10在Ⅰ、Ⅱ、Ⅲ期子宮內膜腺癌組織中錶達暘性率分彆為64.3％(9/14)、30.0％(3/10)、10.0％(1/10),兩兩比較差異均有統計學意義(均P＜0.05).KLK10在高、中、低分化的內膜腺癌組織中錶達暘性率分彆為66.7％(8/12)、33.3％(4/ 12)、10.0％(1/10),兩兩比較差異均有統計學意義(均P＜ 0.05).34例子宮內膜腺癌組織中,KLK10錶達暘性率為38.2％,ER、PR錶達暘性率為67.6％、55.9％,KLK10與ER、PR錶達均呈正相關(x2=0.448,P＜0.01).結論 KLK1O錶達缺失或下調可能促進子宮內膜腺癌的髮生和髮展.KLK10在子宮內膜腺癌組織中錶達降低,ER、PR的錶達也降低,呈正相關.KLK10暘性者預後相對較好.
목적 검측인류조직격태석방매10(KLK10)재불동자궁내막조직중적표체,병탐토기여자격소수체(ER)화잉격소수체(PR)지간적상관성.방법 응용면역조직화학방법측정KLK10재12례정상자궁내막、19례자궁내막증생증、34례자궁내막선암조직중적표체,병분석KLK10여ER、PR지간적상관성.결과 KLK10재정상자궁내막조직、자궁내막증생증조직、자궁내막선암조직중양성솔분별위91.7％(11/12)、78.9％(15/19)、38.2％(13/34),량량비교차이균유통계학의의(균P＜0.05).KLK10재Ⅰ、Ⅱ、Ⅲ기자궁내막선암조직중표체양성솔분별위64.3％(9/14)、30.0％(3/10)、10.0％(1/10),량량비교차이균유통계학의의(균P＜0.05).KLK10재고、중、저분화적내막선암조직중표체양성솔분별위66.7％(8/12)、33.3％(4/ 12)、10.0％(1/10),량량비교차이균유통계학의의(균P＜ 0.05).34례자궁내막선암조직중,KLK10표체양성솔위38.2％,ER、PR표체양성솔위67.6％、55.9％,KLK10여ER、PR표체균정정상관(x2=0.448,P＜0.01).결론 KLK1O표체결실혹하조가능촉진자궁내막선암적발생화발전.KLK10재자궁내막선암조직중표체강저,ER、PR적표체야강저,정정상관.KLK10양성자예후상대교호.
Objective To evaluate the expression of human kallikrein10 (KLK10) in different endometrioid tissues and analyse the relationship of KLK10 with ER and PR in endometrioid adenoearcinoma.Methods The expression of KLK10 protein in 12 normal endometria,19 endometrial hyperplasia and 34 endometrial carcinoma were detected by immunohistochemistry.The correlations of the expression of KLK10 protein,ER and PR were analyzed.Results The expression of KLK10 in stage Ⅰ,Ⅱ and Ⅲ were 64.3 ％(9/14),30.0 ％ (3/10),10.0 ％ (1/10),and the difference was statistically significant (P ＜ 0.05).The expression of KLK10 in endometrial carcinoma,normal endometria,endometrial hyperplasia were 66.7 ％ (8/12),33.3 ％(4/12),10.0 ％ (1/10),and the difference was statistically significant (P ＜ 0.05).The expression of KLK10 in G1,G2,G3 were 66.7 ％,33.3 ％,10.0 ％,and the difference was statistically significant (P ＜ 0.05).The positive rate of KLK10 expression was 38.2 ％ and the positive rates of ER and PR expression were 67.6 ％and 55.9 ％,respectively,in 34 endometrial carcinoma.The expression of KLK10 was positively correlated with ER and PR expression (x2 =0.448,P ＜ 0.01).Conclusion Absence or down-regulated expression of KLK10 may play an important role in the formation and development of endometrioid adenocarcinoma.The low expression of KLK10 is correlated with low expression of ER and PR in endometrioid adenocarcinoma.The positive expression of KLK00,ER and PR predicts a better prognosis.
