CAJ | 학술논문

目的研究加兰肽(GLA)在前列腺癌组织中的表达及其临床意义.方法采用免疫组织化学法检测GLA在50例前列腺增生、50例前列腺癌和30例发生骨转移的前列腺癌组织中的表达.结果 GLA在前列腺增生、前列腺癌及骨转移前列腺癌组织中阳性表达率分别为18％(9/50)、68％(34/50)和80％(24/30),前列腺癌及骨转移组阳性表达率高于前列腺增生组,组间比较差异有统计学意义(x2值分别为25.5、29.74,均P＜0.01),但骨转移组与前列腺癌组阳性表达率比较差异无统计学意义(x2=1.35,P＞ 0.05).结论 GLA在前列腺癌组织中有较高表达,可作为良恶性前列腺疾病的鉴别指标,为前列腺癌的诊断及预测预后提供一定依据.
목적 연구가란태(GLA)재전렬선암조직중적표체급기림상의의.방법 채용면역조직화학법검측GLA재50례전렬선증생、50례전렬선암화30례발생골전이적전렬선암조직중적표체.결과 GLA재전렬선증생、전렬선암급골전이전렬선암조직중양성표체솔분별위18％(9/50)、68％(34/50)화80％(24/30),전렬선암급골전이조양성표체솔고우전렬선증생조,조간비교차이유통계학의의(x2치분별위25.5、29.74,균P＜0.01),단골전이조여전렬선암조양성표체솔비교차이무통계학의의(x2=1.35,P＞ 0.05).결론 GLA재전렬선암조직중유교고표체,가작위량악성전렬선질병적감별지표,위전렬선암적진단급예측예후제공일정의거.
Objective To study the expression and significance of galanin (GLA) in the prostate carcinoma (PCa).Methods The samples from 50 patients with benign prostatic hyperplasia (BPH) and 50 patients with PCa and 30 PCa patients with bone metastasis were examined by immunohistochemical staining.Results The positive rates of GLA expression in BPH,PCa,and PCa with bone metastasis were 18 ％ (9/50),68 ％ (34/50),and 80 ％ (24/30),respectively,and there were statistically significant differences between PCa patients,PCa patients with bone metastasis and BPH patients (x2 =25.5,29.74,both P ＜ 0.01),but there was no significant difference between PCa patients and PCa patients with bone metastasis (x2 =1.35,P ＞ 0.05).Conclusion GLA has higher expression in prostatic cancer cells,it might be an important indicators for differentiating prostate cancer from benign prostatic hyperplasia and predicting the prognosis of prostate carcinoma.