肿瘤研究与临床
腫瘤研究與臨床
종류연구여림상
CANCER RESEARCH AND CLINIC
2012年
11期
760-762
,共3页
徐锦屏%沈卫达%张芸%赵学军%李冰%王忠英%朱海云
徐錦屏%瀋衛達%張蕓%趙學軍%李冰%王忠英%硃海雲
서금병%침위체%장예%조학군%리빙%왕충영%주해운
乳腺肿瘤%MUC-1%CD44v6%预后
乳腺腫瘤%MUC-1%CD44v6%預後
유선종류%MUC-1%CD44v6%예후
Breast carcinoma% MUC-1 % CD44v6% Prognosis
目的 探讨MUC-1和CD44v6在乳腺癌中的表达及其意义.方法 采用免疫组织化学二步法检测93例不同病理类型的乳腺癌中MUC-1和CD44v6的表达,并进行相关分析.结果 MUC-1、CD44v6 在93例乳腺癌中的阳性表达率分别为71.0％(66/93)和63.4％(59/93).MUC-1的表达在不同类型、临床分期及体积的乳腺癌中,差异均无统计学意义(均P＞0.05),而在不同组织学分级(14.3％、69.4％、100.0％)、有无淋巴结转移(22.9％、100.0％)的乳腺癌中,则差异有统计学意义(x2值分别为36.147、63.047,均P＜0.0001)；CD44v6的表达在不同组织学类型、体积及组织学分级的乳腺癌中,差异均无统计学意义(均P＞0.05),而在不同临床分期(6.3％、64.6％、93.1％)、有无淋巴结转移(20.0％、89.7％)的乳腺癌中,则差异有统计学意义(x2值分别为9.507、45.662,均P＜0.05).结论 MUC-1和CD44v6在乳腺癌的发生、发展中起着重要的调控作用.MUC-1和CD44v6的高表达与乳腺癌的生物学行为密切相关,对判断乳腺癌的预后和指导临床治疗均有重要意义.
目的 探討MUC-1和CD44v6在乳腺癌中的錶達及其意義.方法 採用免疫組織化學二步法檢測93例不同病理類型的乳腺癌中MUC-1和CD44v6的錶達,併進行相關分析.結果 MUC-1、CD44v6 在93例乳腺癌中的暘性錶達率分彆為71.0％(66/93)和63.4％(59/93).MUC-1的錶達在不同類型、臨床分期及體積的乳腺癌中,差異均無統計學意義(均P＞0.05),而在不同組織學分級(14.3％、69.4％、100.0％)、有無淋巴結轉移(22.9％、100.0％)的乳腺癌中,則差異有統計學意義(x2值分彆為36.147、63.047,均P＜0.0001)；CD44v6的錶達在不同組織學類型、體積及組織學分級的乳腺癌中,差異均無統計學意義(均P＞0.05),而在不同臨床分期(6.3％、64.6％、93.1％)、有無淋巴結轉移(20.0％、89.7％)的乳腺癌中,則差異有統計學意義(x2值分彆為9.507、45.662,均P＜0.05).結論 MUC-1和CD44v6在乳腺癌的髮生、髮展中起著重要的調控作用.MUC-1和CD44v6的高錶達與乳腺癌的生物學行為密切相關,對判斷乳腺癌的預後和指導臨床治療均有重要意義.
목적 탐토MUC-1화CD44v6재유선암중적표체급기의의.방법 채용면역조직화학이보법검측93례불동병리류형적유선암중MUC-1화CD44v6적표체,병진행상관분석.결과 MUC-1、CD44v6 재93례유선암중적양성표체솔분별위71.0％(66/93)화63.4％(59/93).MUC-1적표체재불동류형、림상분기급체적적유선암중,차이균무통계학의의(균P＞0.05),이재불동조직학분급(14.3％、69.4％、100.0％)、유무림파결전이(22.9％、100.0％)적유선암중,칙차이유통계학의의(x2치분별위36.147、63.047,균P＜0.0001)；CD44v6적표체재불동조직학류형、체적급조직학분급적유선암중,차이균무통계학의의(균P＞0.05),이재불동림상분기(6.3％、64.6％、93.1％)、유무림파결전이(20.0％、89.7％)적유선암중,칙차이유통계학의의(x2치분별위9.507、45.662,균P＜0.05).결론 MUC-1화CD44v6재유선암적발생、발전중기착중요적조공작용.MUC-1화CD44v6적고표체여유선암적생물학행위밀절상관,대판단유선암적예후화지도림상치료균유중요의의.
Objective To investigate the expression of MUC-1 and CD44v6 in breast carcinoma and its diagnostic value.Methods 93 cases of breast carcinoma were examined by immunohistochemical method for MUC-1 and CD44v6.Results The positive rates of MUC-1 and CD44v6 were 71.0 ％ (66/93) and 63.4 ％ (59/93),respectively.The expression of MUC-1 in breast carcinoma was correlated with histologic differentiation (14.3 ％,69.4 ％,100.0 ％) and lymph node metastasis (22.9 ％,100.0 ％) (x2 =36.147,63.047,both P ＜ 0.0001),but had no relationship with the type of breast carcinoma,tumor clinical stages,and tumor size (all P ＞ 0.05).The expression of CD44v6 in breast carcinoma was correlated with tumor clinical stages (6.3 ％,64.6 ％,93.1％) and lymphnode metastasis (20.0 ％,89.7 ％) (x2 =9.507,45.662,both P＜0.05),but had no relationship with tumor type,tumor clinical stages and tumor size (all P ＞ 0.05).Conclusion MUC-1 and CD44v6 may play important roles in the development of breast carcinoma and the biologic behavior of breast carcinoma may be closely related with over expression of MUC-1 and CD44v6 protein.MUC-1 and CD44v6 can be used to predict the prognosis and direct the treatment of breast carcinoma.
