肿瘤研究与临床
腫瘤研究與臨床
종류연구여림상
CANCER RESEARCH AND CLINIC
2013年
1期
22-24
,共3页
陈意标%张汉雄%蒋振东%刘挺%朱文标%邓国明
陳意標%張漢雄%蔣振東%劉挺%硃文標%鄧國明
진의표%장한웅%장진동%류정%주문표%산국명
食管肿瘤%三维适形放疗%同期化疗
食管腫瘤%三維適形放療%同期化療
식관종류%삼유괄형방료%동기화료
Esophagus neoplasms%Three-dimensional conformal radiotherapy%Concurrent chemotherapy
目的 分析食管多发癌三维适形放疗联合同期化疗的疗效及患者不良反应.方法 收集15例拒绝手术治疗的食管多发癌患者,采用直线加速器6 MV/10 MV X线分3～4个共面野进行适形照射,2 Gy/次,1次/d,5次/周；临床靶区剂量40～ 50 Gy/4～5周,肿瘤靶区剂量60 Gy/6周；同期采用TP方案(紫杉醇+顺铂)第1、29天联合化疗；化疗后第2天开始行三维适形放疗.结果 所有患者1、3年局部控制率和总生存率分别为86.7％(13/15)、33.4％(5/15)和73.3％(11/15)、26.6％(4/15).不良反应:1～2级、3～4级急性放射性食管炎和白细胞减少症发生率分别为86.7％(13/15)、13.3％(2/15)和80.0％(12/15)、20.0％(3/15).结论 对于近端病灶位于胸上段甚至颈段的食管多发癌,放疗是较好的治疗手段；三维适形放疗联合同期化疗治疗食管多发癌的不良反应可耐受.
目的 分析食管多髮癌三維適形放療聯閤同期化療的療效及患者不良反應.方法 收集15例拒絕手術治療的食管多髮癌患者,採用直線加速器6 MV/10 MV X線分3～4箇共麵野進行適形照射,2 Gy/次,1次/d,5次/週；臨床靶區劑量40～ 50 Gy/4～5週,腫瘤靶區劑量60 Gy/6週；同期採用TP方案(紫杉醇+順鉑)第1、29天聯閤化療；化療後第2天開始行三維適形放療.結果 所有患者1、3年跼部控製率和總生存率分彆為86.7％(13/15)、33.4％(5/15)和73.3％(11/15)、26.6％(4/15).不良反應:1～2級、3～4級急性放射性食管炎和白細胞減少癥髮生率分彆為86.7％(13/15)、13.3％(2/15)和80.0％(12/15)、20.0％(3/15).結論 對于近耑病竈位于胸上段甚至頸段的食管多髮癌,放療是較好的治療手段；三維適形放療聯閤同期化療治療食管多髮癌的不良反應可耐受.
목적 분석식관다발암삼유괄형방료연합동기화료적료효급환자불량반응.방법 수집15례거절수술치료적식관다발암환자,채용직선가속기6 MV/10 MV X선분3～4개공면야진행괄형조사,2 Gy/차,1차/d,5차/주；림상파구제량40～ 50 Gy/4～5주,종류파구제량60 Gy/6주；동기채용TP방안(자삼순+순박)제1、29천연합화료；화료후제2천개시행삼유괄형방료.결과 소유환자1、3년국부공제솔화총생존솔분별위86.7％(13/15)、33.4％(5/15)화73.3％(11/15)、26.6％(4/15).불량반응:1～2급、3～4급급성방사성식관염화백세포감소증발생솔분별위86.7％(13/15)、13.3％(2/15)화80.0％(12/15)、20.0％(3/15).결론 대우근단병조위우흉상단심지경단적식관다발암,방료시교호적치료수단；삼유괄형방료연합동기화료치료식관다발암적불량반응가내수.
Objective To analysis of the efficacy and toxicity of multiple primary cancer of esophagus in three-dimensional conformal radiotherapy and concomitant chemotherapy.Methods Fifteen cases of multiple primary carcinoma of esophagus who refused the operation were collected.The Elekta linac 6 MV/10 MV X ray was used to conformal irradiation in three-four coplanar wild,2 Gy/time,1 time/day,5 times/week.The dose to the target area,CTV 40-50 Gy/4-5 weeks,GTV 60 Gy/6 weeks.TP scheme (paclitaxel+cisplatin) was used in the first day and 29th day,three-dimensional conformal radiation therapy initiated in the second day after chemotherapy.Results 1,3 year local control and overall survival were 86.7 ％ (13/15),33.4 ％ (5/15) and 73.3 ％ (11/15),26.6 ％ (4/15).Class 1-2 and class 3-4 acute radiation esophagitis and leukopenia occurred rates were 86.7 ％ (13/15),13.3 ％ (2/15) and 80 ％ (12/15),20 ％ (3/15).Conclusion Radiation therapy is the better treatment method for multiple primary carcinoma of esophagus when proximal lesions located in upper thoracic and cervical high.Toxic and side-effects can be tolerated of three dimensional conformal radiation therapy combined with chemotherapy in the treatment of multiple esophageal cancer.
