肿瘤研究与临床
腫瘤研究與臨床
종류연구여림상
CANCER RESEARCH AND CLINIC
2013年
1期
29-31,35
,共4页
刘鹏辉%廖国清%李亮亮%曲怡梅
劉鵬輝%廖國清%李亮亮%麯怡梅
류붕휘%료국청%리량량%곡이매
肿瘤%谷氨酰胺%免疫功能%胃肠外营养
腫瘤%穀氨酰胺%免疫功能%胃腸外營養
종류%곡안선알%면역공능%위장외영양
Neoplasms%Glutamine%Immune function%Parenteral nutrition
目的 探讨强化L-丙氨酰-L-谷氨酰胺(LALG)的肠外营养对恶性肿瘤患者营养支持的应用价值.方法 将68例恶性肿瘤患者按数字表法随机分为两组,每组34例,对照组单纯给予肠外营养,治疗组除给予肠外营养外,按每日0.3g/kg补充LALG.分别测定在用药前和用药后第15天营养指标、免疫功能指标.结果 治疗组在肠外营养后前清蛋白(pALB)和转铁蛋白(TRF)水平比营养支持前明显上升[(24.9±8.06) mg /dl比(27.3±6.05) mg/dl;(1.62±0.43)g/L比(2.06±0.32)g/L],差异有统计学意义(P＜0.05).在治疗前,治疗组和对照组IgA、IgM、IgG差异无统计学意义(P＞0.05)；治疗组治疗后的IgA和IgG水平均高于治疗前[(2.85±1.43)mg/L比(3.63±5.36)mg/L;(0.95±0.43)mg/L比(1.13±0.09)mg/L],差异有统计学意义(P＜0.05)；而对照组治疗前后IgA、IgM和IgG差异无统计学意义(P＞0.05).治疗组治疗后的CD+4值高于对照组[(39.19±4.23)％比(36.62±3.58)％],差异有统计学意义(P＜0.05)；治疗组的CD4+/CD8+、CD8+值与对照组比较,差异无统计学意义(P＞0.05).治疗组治疗后生活质量高于对照组(P＜0.05).结论 LALG与单纯肠外营养联合比单纯的肠外营养更能明显改善晚期恶性肿瘤患者的营养状况、免疫功能.
目的 探討彊化L-丙氨酰-L-穀氨酰胺(LALG)的腸外營養對噁性腫瘤患者營養支持的應用價值.方法 將68例噁性腫瘤患者按數字錶法隨機分為兩組,每組34例,對照組單純給予腸外營養,治療組除給予腸外營養外,按每日0.3g/kg補充LALG.分彆測定在用藥前和用藥後第15天營養指標、免疫功能指標.結果 治療組在腸外營養後前清蛋白(pALB)和轉鐵蛋白(TRF)水平比營養支持前明顯上升[(24.9±8.06) mg /dl比(27.3±6.05) mg/dl;(1.62±0.43)g/L比(2.06±0.32)g/L],差異有統計學意義(P＜0.05).在治療前,治療組和對照組IgA、IgM、IgG差異無統計學意義(P＞0.05)；治療組治療後的IgA和IgG水平均高于治療前[(2.85±1.43)mg/L比(3.63±5.36)mg/L;(0.95±0.43)mg/L比(1.13±0.09)mg/L],差異有統計學意義(P＜0.05)；而對照組治療前後IgA、IgM和IgG差異無統計學意義(P＞0.05).治療組治療後的CD+4值高于對照組[(39.19±4.23)％比(36.62±3.58)％],差異有統計學意義(P＜0.05)；治療組的CD4+/CD8+、CD8+值與對照組比較,差異無統計學意義(P＞0.05).治療組治療後生活質量高于對照組(P＜0.05).結論 LALG與單純腸外營養聯閤比單純的腸外營養更能明顯改善晚期噁性腫瘤患者的營養狀況、免疫功能.
목적 탐토강화L-병안선-L-곡안선알(LALG)적장외영양대악성종류환자영양지지적응용개치.방법 장68례악성종류환자안수자표법수궤분위량조,매조34례,대조조단순급여장외영양,치료조제급여장외영양외,안매일0.3g/kg보충LALG.분별측정재용약전화용약후제15천영양지표、면역공능지표.결과 치료조재장외영양후전청단백(pALB)화전철단백(TRF)수평비영양지지전명현상승[(24.9±8.06) mg /dl비(27.3±6.05) mg/dl;(1.62±0.43)g/L비(2.06±0.32)g/L],차이유통계학의의(P＜0.05).재치료전,치료조화대조조IgA、IgM、IgG차이무통계학의의(P＞0.05)；치료조치료후적IgA화IgG수평균고우치료전[(2.85±1.43)mg/L비(3.63±5.36)mg/L;(0.95±0.43)mg/L비(1.13±0.09)mg/L],차이유통계학의의(P＜0.05)；이대조조치료전후IgA、IgM화IgG차이무통계학의의(P＞0.05).치료조치료후적CD+4치고우대조조[(39.19±4.23)％비(36.62±3.58)％],차이유통계학의의(P＜0.05)；치료조적CD4+/CD8+、CD8+치여대조조비교,차이무통계학의의(P＞0.05).치료조치료후생활질량고우대조조(P＜0.05).결론 LALG여단순장외영양연합비단순적장외영양경능명현개선만기악성종류환자적영양상황、면역공능.
Objective To evaluate the effects of L-alanyl-L-glutamine (LALG) intensified parenteral nutrition support in advanced malignant carcinoma patients.Methods 68 patients were randomly divided into two groups,control group (n =34) received only parenteral nutrition,treatment group (n =34) received parenteral nutrition combined with a dose of 0.3 g ·(kg·d)-1 LALG.Nutrition status and immune functions were determined at pre-therapy and 15th days after therapy.Results After the therapy,the pALB and TRF of treatment group were significantly increased [(24.9±8.06) mg/dl vs (27.3±6.05) mg/dl; (1.62±0.43) g/L vs (2.06±0.32) g/L].Before therapy,no significant change in IgA,IgM and IgG was found in two groups (P ＞ 0.05).After the therapy,IgA and IgG of the treatment group after the therapy were significantly different from those before the therapy [(2.85±1.43) mg/L vs (3.63±5.36) mg/L; (0.95±0.43) mg/L vs (1.13±0.09) mg/L],IgA,IgM and IgG of the control group had no difference compared with those before the therapy (P ＞ 0.05),CD4+ of treatment group was significandy different compared with those of control group [(39.19±4.23) ％ vs (36.62±3.58) ％] (P ＜ 0.05).There is no significantly difference between CD:/ CD8+ CD8+ of treatment group and those of control therapy (P ＞ 0.05).After therapy,the score of quality of life in treatment group was higher than that in control group (P ＜ 0.05).Conclusion LALG intensified parenteral nutrition has better effects on improvement of the nutrition and immune functions.
