肿瘤研究与临床
腫瘤研究與臨床
종류연구여림상
CANCER RESEARCH AND CLINIC
2013年
1期
36-37,40
,共3页
镇痛药,阿片类%癌痛%疗效%不良反应
鎮痛藥,阿片類%癌痛%療效%不良反應
진통약,아편류%암통%료효%불량반응
Analgesics,opioid%Cancerous pain%Effect%Adverse effect
目的 比较盐酸羟考酮缓释片(商品名:奥施康定,简称羟考酮)和硫酸吗啡缓释片(商品名:美施康定,简称吗啡)治疗晚期恶性肿瘤重度疼痛的疗效及患者不良反应.方法 将204例重度癌性疼痛患者用数字表法随机分为两组,每组102例,分别接受羟考酮和吗啡镇痛治疗,每48 h进行1次疼痛评估,根据疼痛缓解情况调整药物剂量.用药后疼痛评分≤3分者为有效.对两组患者镇痛起效时间、镇痛效果及不良反应进行分析比较.结果 镇痛效果羟考酮组有效率79.4％(81/102),吗啡组有效率75.5％(77/102),两组差异无统计学意义(x2=0.225,P＞0.05)；对疼痛控制的起效时间羟考酮组比吗啡组更快,两组比较差异有统计学意义(x2=22.916,P＜ 0.05).羟考酮组总不良反应发生率为62.7％(64/102),吗啡组为98.0％(99/102),两组间差异有统计学意义(x2=20.151,P＜0.05).结论 羟考酮和吗啡对重度癌痛控制效果相当,但羟考酮镇痛起效快,患者不良反应发生率低,程度轻,具有一定优势.
目的 比較鹽痠羥攷酮緩釋片(商品名:奧施康定,簡稱羥攷酮)和硫痠嗎啡緩釋片(商品名:美施康定,簡稱嗎啡)治療晚期噁性腫瘤重度疼痛的療效及患者不良反應.方法 將204例重度癌性疼痛患者用數字錶法隨機分為兩組,每組102例,分彆接受羥攷酮和嗎啡鎮痛治療,每48 h進行1次疼痛評估,根據疼痛緩解情況調整藥物劑量.用藥後疼痛評分≤3分者為有效.對兩組患者鎮痛起效時間、鎮痛效果及不良反應進行分析比較.結果 鎮痛效果羥攷酮組有效率79.4％(81/102),嗎啡組有效率75.5％(77/102),兩組差異無統計學意義(x2=0.225,P＞0.05)；對疼痛控製的起效時間羥攷酮組比嗎啡組更快,兩組比較差異有統計學意義(x2=22.916,P＜ 0.05).羥攷酮組總不良反應髮生率為62.7％(64/102),嗎啡組為98.0％(99/102),兩組間差異有統計學意義(x2=20.151,P＜0.05).結論 羥攷酮和嗎啡對重度癌痛控製效果相噹,但羥攷酮鎮痛起效快,患者不良反應髮生率低,程度輕,具有一定優勢.
목적 비교염산간고동완석편(상품명:오시강정,간칭간고동)화류산마배완석편(상품명:미시강정,간칭마배)치료만기악성종류중도동통적료효급환자불량반응.방법 장204례중도암성동통환자용수자표법수궤분위량조,매조102례,분별접수간고동화마배진통치료,매48 h진행1차동통평고,근거동통완해정황조정약물제량.용약후동통평분≤3분자위유효.대량조환자진통기효시간、진통효과급불량반응진행분석비교.결과 진통효과간고동조유효솔79.4％(81/102),마배조유효솔75.5％(77/102),량조차이무통계학의의(x2=0.225,P＞0.05)；대동통공제적기효시간간고동조비마배조경쾌,량조비교차이유통계학의의(x2=22.916,P＜ 0.05).간고동조총불량반응발생솔위62.7％(64/102),마배조위98.0％(99/102),량조간차이유통계학의의(x2=20.151,P＜0.05).결론 간고동화마배대중도암통공제효과상당,단간고동진통기효쾌,환자불량반응발생솔저,정도경,구유일정우세.
Objective To evaluate effect and adverse effect of oxycontin and MS contin in the treatment of sever cancerous pain.Methods 204 patients with sever cancerous pain were randomly derided into 2 groups,oxycontin and MS contin group.Each pain was evaluated in every 48 hours and dose was adjusted according to the pain relief.And 2 groups were evaluated the analgesic onset time,effect and adverse effect,respectively.Results Efficiency was according to less than or equal to 3 of pain score after administer in analgesic effect.Effect rates of oxycontin group and MS contin group were 79.4 ％ (81/102) and 75.5 ％ (77/102) respectively,and the difference was not statistically significant (x2 =0.225,P ＞ 0.05).However,there were significant differences in the analgesic onset time between two groups (x2 =22.916,P ＜ 0.05).Adverse effect rates in oxycontin group and MS contin group were 62.7 ％ (64/102) and 98.0 ％ (99/102)respectively,and the difference was statistically significant (x2 =20.151,P ＜ 0.05).Conclusion Oxycontin and MS contin in the treatment of serious cancerous pain have the same controlling effect.But oxycontin worked better with quick analgesic onset,low incidence and few of adverse reaction.
