肿瘤研究与临床
腫瘤研究與臨床
종류연구여림상
CANCER RESEARCH AND CLINIC
2013年
1期
44-46
,共3页
乳腺肿瘤%肿瘤标志物%联合检测
乳腺腫瘤%腫瘤標誌物%聯閤檢測
유선종류%종류표지물%연합검측
Breast neoplasms%Tumor maker%Combined detection
目的 探讨糖类抗原15-3(CA15-3)、癌胚抗原(CEA)、环氧合酶-2(COx-2)联合检测对乳腺癌早期诊断的应用价值.方法 选择经影像学和病理学诊断为乳腺癌患者53例,同时选择同期良性乳腺病患者61例及同期健康体检者68名,采用电化学发光技术与酶联免疫吸附法(ELISA)分别检测血清CA15-3、CEA、COX-2水平.结果 乳腺癌组CA15-3、CEA、COX-2血清水平分别为(34.67±13.20)U/ml、(7.38±3.87) ng/ml、(43.25±10.87) ng/ml,与良性乳腺病组和健康对照组血清含量比较差异具有统计学意义(均P＜0.01)；CA15-3、CEA、COX-2联合检测将各项指标单独检测的阳性检出率提高至84.9％(45/53),其敏感度提高至84.9％,准确度提高至91.2％.结论 三项肿瘤标志物联合应用能弥补单项肿瘤标志物临床应用的不足,对提高乳腺癌阳性检出率具有一定意义.
目的 探討糖類抗原15-3(CA15-3)、癌胚抗原(CEA)、環氧閤酶-2(COx-2)聯閤檢測對乳腺癌早期診斷的應用價值.方法 選擇經影像學和病理學診斷為乳腺癌患者53例,同時選擇同期良性乳腺病患者61例及同期健康體檢者68名,採用電化學髮光技術與酶聯免疫吸附法(ELISA)分彆檢測血清CA15-3、CEA、COX-2水平.結果 乳腺癌組CA15-3、CEA、COX-2血清水平分彆為(34.67±13.20)U/ml、(7.38±3.87) ng/ml、(43.25±10.87) ng/ml,與良性乳腺病組和健康對照組血清含量比較差異具有統計學意義(均P＜0.01)；CA15-3、CEA、COX-2聯閤檢測將各項指標單獨檢測的暘性檢齣率提高至84.9％(45/53),其敏感度提高至84.9％,準確度提高至91.2％.結論 三項腫瘤標誌物聯閤應用能瀰補單項腫瘤標誌物臨床應用的不足,對提高乳腺癌暘性檢齣率具有一定意義.
목적 탐토당류항원15-3(CA15-3)、암배항원(CEA)、배양합매-2(COx-2)연합검측대유선암조기진단적응용개치.방법 선택경영상학화병이학진단위유선암환자53례,동시선택동기량성유선병환자61례급동기건강체검자68명,채용전화학발광기술여매련면역흡부법(ELISA)분별검측혈청CA15-3、CEA、COX-2수평.결과 유선암조CA15-3、CEA、COX-2혈청수평분별위(34.67±13.20)U/ml、(7.38±3.87) ng/ml、(43.25±10.87) ng/ml,여량성유선병조화건강대조조혈청함량비교차이구유통계학의의(균P＜0.01)；CA15-3、CEA、COX-2연합검측장각항지표단독검측적양성검출솔제고지84.9％(45/53),기민감도제고지84.9％,준학도제고지91.2％.결론 삼항종류표지물연합응용능미보단항종류표지물림상응용적불족,대제고유선암양성검출솔구유일정의의.
Objective To investigate the value of combination detection of CA15-3,CEA,COX-2 on early diagnosis of breast carcinoma.Methods 68 breast cancer patients,61 benign breast disease patients and 68 healthies were selected.Serum levels of COX-2 were detected by ELISA technique,CA15-3 and CEA levels were detected by electroche-miluminescence technique.Results Serum levels of CA15-3,CEA,COX-2 in breast carcinoma group were (34.67±13.20) U/ml,(7.38±3.87) ng/ml,(43.25±10.87) ng/ml.Their levels were higher than those in benign breast disease group and healthy group,the differences were significant (P ＜ 0.01).In combination detection,the sensitivity was 84.9 ％,and accuracy was 91.2 ％,which were higher than single tumor marker used in breast cancer diagnosis.Conclusion The combined detection of CA15-3,CEA,COX-2 could increase the diagnosis rate of breast carcinoma.
